A5055005020- Drug Solubulity and Delivery Systems
- Crystallization and Solubility Studies
- Analytical Chemistry and Chromatography
- Nanoparticle-Based Drug Delivery
- Advanced Drug Delivery Systems
- Bone Tissue Engineering Materials
- Oral microbiology and periodontitis research
- Electrospun Nanofibers in Biomedical Applications
- Protein purification and stability
- Bacterial biofilms and quorum sensing
- Renin-Angiotensin System Studies
- Graphene and Nanomaterials Applications
- Protein Interaction Studies and Fluorescence Analysis
- Computational Drug Discovery Methods
- Antimicrobial Peptides and Activities
- Receptor Mechanisms and Signaling
- Analytical Methods in Pharmaceuticals
- Orthopaedic implants and arthroplasty
- Phytoestrogen effects and research
- Research on Leishmaniasis Studies
- Neuropeptides and Animal Physiology
- Biosensors and Analytical Detection
- biodegradable polymer synthesis and properties
- Adsorption and biosorption for pollutant removal
- Inorganic and Organometallic Chemistry
Universidade Federal de Minas Gerais
2015-2024
Instituto Nacional de Metrologia, Qualidade e Tecnologia
2023
Universidade Federal Fluminense
2023
Universidade Estadual de Montes Claros
2013
Touro University Nevada
2013
Charité - Universitätsmedizin Berlin
2013
University of Southern Denmark
2013
University of Florida
2013
Universidade Federal de Ouro Preto
2013
Universidade Federal do Rio Grande do Sul
2010
The renin-angiotensin system (RAS) is a key regulator of the cardiovascular system, electrolyte, and water balance. Here, we report identification characterization alamandine, new heptapeptide generated by catalytic action angiotensin-converting enzyme-2 angiotensin A or directly from angiotensin-(1-7).To characterize novel component RAS, alamandine.Using mass spectrometry observed that alamandine circulates in human blood can be formed angiotensin-(1-7) heart. Alamandine produces several...
In this study we evaluated the cardiac effects of a pharmaceutical formulation developed by including angiotensin (Ang)-(1-7) in hydroxypropyl β-cyclodextrin (HPβCD), normal, infarcted, and isoproterenol-treated rats. Myocardial infarction was produced left coronary artery occlusion. Isoproterenol (2 mg/kg, IP) administered daily for 7 days. Oral administration HPβCD/Ang-(1-7) started immediately before or associated with first dose isoproterenol. After days treatment, rats were euthanized,...
Obesity is characterized by a pro-inflammatory state commonly associated with type 2 diabetes and fat-liver disease. In the last few years, different studies pointed out role of Angiotensin (Ang)-(1-7) in metabolic regulation. The aim present study was to evaluate effect oral-administration Ang-(1-7) metabolism inflammatory high-fat feed rats. Twenty-four male Sprague Dawley rats were randomized into three groups: High Fat Diet (HFD); Standard (ST); Diet+Angiotensin-(1-7) [HFD+Ang-(1-7)]....
The heptapeptide angiotensin-(1-7) is a component of the renin-angiotensin system, which promotes many beneficial cardiovascular effects, including antithrombotic activity. We have recently shown that effect involves receptor Mas-mediated NO-release from platelets. Here, we describe an orally active formulation based on inclusion in cyclodextrin [Ang-(1-7)- CyD] as agent. Cyclodextrins are pharmaceutical tools used to enhance drug stability, absorption across biological barriers and gastric...
Angiotensin (Ang)-(1-7) has been described as an important tool on treating and preventing metabolic disorders. In this study, we aimed to evaluate the effect of oral formulation Ang-(1-7) included in hydroxypropylβ-cyclodextrin (HPβCD/Ang-[1-7]) hepatic function, steatosis, liver inflammatory markers expression mice treated with a high-fat diet. Male FVB/N were divided into 4 groups fed for 60 days, each group receiving 1 following diets: standard diet+HPβCD, diet+Ang-(1-7)/HPβCD, or...
The present work demonstrated an efficient cutaneous wound healing using Bixin-loaded polycaprolactone (PCL) nanofibers as a controlled delivery system. influence of Bixin (Bix) content on PCL nanofiber, Bix-PCL1(2.5% w/w bix) and Bix-PCL2 (12.5% formation was investigated electrical conductivity, attenuated total reflectance infrared spectroscopy, X-ray diffraction, thermal analysis, scanning electronic microscopy. results showed that greater bixin concentration resulted in higher polymeric...
The supramolecular interactions between Imipramine hydrochloride (IMI), a tricyclic antidepressant, and β-cyclodextrin (βCD) have been investigated by experimental techniques theoretical calculations. association these molecules might be lead to host/guest compound, in which the physical chemistry properties of guest molecule, such as high solubility, can decreased. These new acquired inclusion phenomena are important develop strategy for pharmaceutical formulation. Nuclear magnetic...
In this study was evaluated the chronic cardiac effects of a formulation developed by including angiotensin(Ang)-(1–7) in hydroxypropyl β -cyclodextrin (HP CD), infarcted rats. Myocardial infarction (MI) induced left coronary artery occlusion. HP CD/Ang-(1–7) administered for 60 days (76 μ g/Kg/once day/gavage) starting immediately before infarction. Echocardiography utilized to evaluate usual parameters, and radial strain method used analyze velocity displacement myocardial fibers at...
Summary Angiotensin (Ang)-(1–7), acting through the receptor Mas, has atheroprotective effects; however, its role on plaque vulnerability been poorly studied. Here, we investigated expression of renin-angiotensin system (RAS) components in stable and unstable human carotid plaques. In addition, evaluated effects chronic treatment with an oral formulation Ang-(1–7) a mouse model shear stress-determined atherosclerotic plaque. Upstream downstream regions internal plaques were obtained from...
In the present work, we study role of different components in formation more stable iron oxide magnetic nanoparticles (MNPs): β-cyclodextrin (BCD), 2-hydroxypropyl-β-cyclodextrin (HP) and citrate anion. MNPs formulations were characterized by FTIR, particles size measurements, zeta potential based on dynamic light scattering principle technique, X-ray powder pattern diffraction, XPS spectroscopy, transmission electron microscopy thermogravimetric analysis. The results showed that...
ABSTRACT The need for daily parenteral administration represents one of the most serious limitations in clinical use pentavalent antimonials against leishmaniasis. In this work, we investigated ability β-cyclodextrin to enhance oral absorption antimony and promote efficacy meglumine antimoniate experimental cutaneous occurrence interactions between was demonstrated through changes induced spin lattice relaxation times protons both compounds. When free complexed were given orally Swiss mice,...
Tunable and durable photochromic materials are a rapidly expanding area of interest, with applications ranging from biomedical devices to industrial-fields. Here we examine electrospun poly (methacrylic acid) PMAA nanofibers covalently modified the highly molecule, spiropyran (SP) or derivate SP which is firstly coupled cyclodextrin molecule (βCDSP). The properties starting were investigated. βCDSP, PMAASP PMAA-βCDSP polymers exhibited reverse photochromism. kinetic results revealed faster...
Sertraline (SRT) is a widely used antidepressant whose poor solubility in water limits its oral applicability. Thus, the aim of this work was evaluation multi-equilibrium system based on β-cyclodextrin (βCD) and SRT. The inclusion compounds (ICs) were investigated by infrared spectroscopy, isothermal titration calorimetry (ITC) (1)H 2D ROESY nuclear magnetic resonance experiments. SRT predicted vitro biomimetic fluids. presence βCD at 1:1 1:2 molar ratios more soluble than free all...