A5090291376- Heart Rate Variability and Autonomic Control
- Neuroscience of respiration and sleep
- Cardiovascular Syncope and Autonomic Disorders
- Nitric Oxide and Endothelin Effects
- Hormonal Regulation and Hypertension
- Pomegranate: compositions and health benefits
- Science and Education Research
- Cardiac Arrhythmias and Treatments
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Metabolism and Genetic Disorders
- Neuroscience and Neuropharmacology Research
- Cardiovascular Health and Disease Prevention
- Regulation of Appetite and Obesity
- Neuroendocrine regulation and behavior
- Renal and Vascular Pathologies
- Ion channel regulation and function
- Cardiac electrophysiology and arrhythmias
- Aortic Disease and Treatment Approaches
- Cardiovascular Function and Risk Factors
- Antiplatelet Therapy and Cardiovascular Diseases
- Adipose Tissue and Metabolism
- Pulmonary Hypertension Research and Treatments
- Renin-Angiotensin System Studies
- Education during COVID-19 pandemic
- Marine Invertebrate Physiology and Ecology
Universidade Federal do Espírito Santo
2003-2023
University College London
2013
University of Finance and Economics
2004
Universidade de São Paulo
1992-1995
Universidade de Ribeirão Preto
1995
Montreal Clinical Research Institute
1992
Université de Montréal
1992
The University of Texas Southwestern Medical Center
1992
Based on the antioxidant properties of pomegranate, this study was designed to investigate effects pomegranate peel extract damage associated with hypertension and aging in a spontaneously hypertensive rat (SHR) model. The influence consumption examined systolic blood pressure (SBP), angiotensin-converting enzyme (ACE) coronary activity, oxidative stress, vascular morphology. Four- or 28-wk-old SHR model rats were treated for 30 d, terminal experimental animal age being 8 32 wk,...
Vagal cardioinhibition is exerted through a reduction not only in the heart rate but also of propagation cardiac action potential and myocardial contractility. In several species, such effects can be produced independently by selective activation ganglia identified ‘fat pads’. this study we investigate differential control atrioventricular conduction two ganglionic clusters rat, species increasingly important studies cardiovascular control. Epicardial sites producing low‐threshold changes...
Our previous studies have shown that stimulation of the anteroventral third ventricle (AV3V) region brain increases atrial natriuretic peptide (ANP) release, whereas lesions AV3V or median eminence tuber cinereum block release ANP caused by blood volume expansion. These results suggest participation central nervous system is critical to this response. The role baroreceptors in response was evaluated current research studying plasma expansion induced intravenous injection hypertonic saline...
The cell biology discipline constitutes a highly dynamic field whose concepts take long time to be incorporated into the educational system, especially in developing countries. Amongst main obstacles introduction of new students is their general lack identification with most teaching methods. elaborated figures, movies and animations textbooks has given tremendous contribution learning process search for novel methods been central goal education. Some specialized tools, however, are usually...
Experimental studies show that the unsaturated high-fat diet-induced obesity promotes vascular alterations characterized by improving endothelial L-arginine/Nitric Oxide (NO) pathway. Leptin seems to be involved in this process, promoting vasodilation via increasing NO bioavailability. We investigated involvement of leptin on reactivity aortic rings obese rats. Furthermore, test hypothesis improvement at vasodilator response observed induced diet rich fatty occurs mainly due an increase...
The aim of the present study was to investigate cardiovascular activity Scorpaena plumieri venom in both vivo and vitro models. In anesthetized rats, doses (14-216 microg protein/kg) induced a transient increase mean arterial pressure. However at higher dose (338 this effect followed by sudden hypotension animal evolved death. heart rate temporarily increased bradycardia using > or =108 microg/kg. isolated rat hearts crude (5-80 protein) produced dose-dependent positive ventricular...
Decline in estrogen levels promotes endothelial dysfunction and, consequently, the most prevalent cardiovascular diseases menopausal women. The use of natural therapies such as pomegranate can change these results. Pomegranate [Punica granatum L. (Punicaceae)] is widely used a phytotherapeutic agent worldwide, including Brazil. We hypothesized that treatment with hydroalcoholic extract (PHE) would improve coronary vascular reactivity and parameters. At beginning treatment, spontaneously...
Angiotensin II is a key player in the pathogenesis of renovascular hypertension, condition associated with endothelial dysfunction. We investigated aliskiren (ALSK) and L-arginine treatment both alone combination on blood pressure (BP), vascular reactivity aortic rings. Hypertension was induced 40 male Wistar rats by clipping left renal artery. Animals were divided into Sham, 2-kidney, 1-clip (2K1C) 2K1C+ALSK (ALSK), 2K1C+L-arginine (L-arg), 2K1C+ALSK+L-arginine (ALSK+L-arg) groups. For 4...
The cardioinhibitory effects of cardiac vagal motoneurons (CVMs) are mediated by activation postganglionic neurons in the epicardial ganglia which have been shown to exert functionally selective on heart rate and atrioventricular conduction rat. Here we investigate whether CVMs producing these responses may occupy different rostrocaudal positions within nucleus ambiguus. Excitation was attempted microinjections glutamate into ambiguus an arterially perfused preparation a grid extending over...
Anatomical studies have demonstrated the existence of purinergic P2 receptors in nucleus ambiguus (NA), a site containing cardiac vagal motoneurons. However, very little is known about functional role these central regulation. The aims our study were to evaluate following: (1) blood pressure and heart rate responses following purinoceptor activation within NA; (2) purinoceptors excitatory amino acid (EAA) mediating cardiovascular evoked by ATP L-glutamate stimulation (3) NA Bezold-Jarisch...
Mobility of fat deposited in adipocytes among different fatty territories can play a crucial role the pathogenesis obesity-related diseases. Our goal was to investigate which remaining pads assume accumulating lipids after surgical removal parietal WAT (lipectomy; LIPEC) rats both sexes displaying MSG-induced obesity.The animals entered study straight birth, being separated according gender and randomly divided into CON (control, saline-treated) MSG (monosodium glutamate-treated) groups....
Earlier studies report that sinoaortic baroreceptor denervation (SAD) in rats causes moderate elevation of mean arterial pressure along with a marked increase lability (APL). In this context, we studied the effects selective aortic (AD) or carotid (CD) on regulation blood pressure. addition, evaluated total pulmonary ventilation and ventilation-related changes Mean was by computer-assisted techniques, measured whole body plethysmography conscious freely moving rats. With approach, equal...
Sinoaortic deafferentation (SAD) in rats produces moderate increases mean arterial pressure (MAP) along with a large augmentation of lability (APL). The mechanisms generating this APL are incompletely understood. To study the possible influence breathing activity on conscious SAD rats, we simultaneously recorded pulmonary ventilation and blood pressure. general pattern was same normal, sham-operated, rats. In all groups single tidal volumes were regularly interposed 1- to 2-min periods...
The contribution of α 2 -receptor mechanisms in the rostral ventrolateral medulla (RVLM) mediating enhanced renal excretory responses evoked by intravenous infusion agonist xylazine was examined ketamine-anesthetized rats. In rats, bilateral microinjection antagonist yohimbine into RVLM significantly reduced levels urine flow rate (V) and urinary sodium excretion (UNaV) produced xylazine. contrast, chronically bilaterally renal-denervated rats xylazine-evoked diuretic, but not natriuretic,...
Abstract We compared the effects of 2‐month CPAP or exercise training (ET) therapies on autonomic balance in moderate to severe obstructive sleep apnea (OSA) through heart rate variability (HRV) analysis. Thirty‐nine OSA patients were divided into ( n = 18) and ET 21) groups, being further split hypertensive non‐hypertensive subgroups. All submitted continuous ECG recordings for HRV Hemodynamic parameters recorded by oscillometry. Excessive daytime sleepiness quality assessed Epworth...