A5043153028- Vascular Anomalies and Treatments
- Wound Healing and Treatments
- Reconstructive Surgery and Microvascular Techniques
- Tissue Engineering and Regenerative Medicine
- Pulmonary Hypertension Research and Treatments
- Mesenchymal stem cell research
- Renal and related cancers
- Angiogenesis and VEGF in Cancer
- Chemokine receptors and signaling
- Hemostasis and retained surgical items
- Tracheal and airway disorders
- Renal cell carcinoma treatment
- Reproductive System and Pregnancy
- Protease and Inhibitor Mechanisms
- Intestinal and Peritoneal Adhesions
- Medical and Biological Ozone Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cardiomyopathy and Myosin Studies
- Pancreatic function and diabetes
- Venomous Animal Envenomation and Studies
- Bone Tissue Engineering Materials
- Nanoparticle-Based Drug Delivery
- Uterine Myomas and Treatments
- Cardiovascular Issues in Pregnancy
- Proteoglycans and glycosaminoglycans research
Universidade Federal de Minas Gerais
2015-2025
University of Concepción
2024
Hospital de Santa Maria
2003-2022
Centro Hospitalar Lisboa Norte
2009-2021
Universidade Federal do Rio de Janeiro
2021
University of Lisbon
2016-2019
John Wiley & Sons (United States)
2018
Obesity Society
2018
Centro Hospitalar de Lisboa Central
2017
Fundação Oswaldo Cruz
2016
Mucosal healing (MH) is currently accepted as one of the best treatment targets in Crohn's disease. However, even patients with sustained MH, residual bowel wall inflammation can still be detected by cross-sectional imaging. The long-term benefits obtaining transmural (TH) have not been previously assessed.We performed an observational study including 214 disease a magnetic resonance enterography (MRE) and colonoscopy within 6-month interval. Patients were classified having TH (inactive MRE...
Thiamine is an important cofactor of metabolic enzymes, and its deficiency leads to cardiovascular dysfunction. First, we characterized the status measuring resting oxygen consumption rate lactate blood concentration after 35 days thiamine (TD). The results pointed a decrease in twofold increase lactate. Confocal microscopy showed that intracellular superoxide (∼40%) H 2 O (2.5 times) contents had been increased. In addition, biochemical activities protein expression SOD, glutathione...
Inflammation and angiogenesis are key components of fibrovascular tissue growth, a biological event underlying both physiological (wound healing) pathological conditions (tumor development, chronic inflammation). We investigated these in three frequently used mouse strains (Swiss, Balb/c C57BL/6J) to verify the influence genetic background on kinetics inflammatory cell recruitment/activation, neovascularization, extracellular matrix deposition, cytokine production polyether-polyurethane...
Pentavalent antimonial drugs such as meglumine antimoniate (Glucantime [Glu; Sanofi-Aventis, São Paulo, Brazil]) produce severe side effects, including cardiotoxicity and hepatotoxicity, during the treatment of leishmaniasis. We evaluated role residual Sb(III) in hepatotoxicity antimoniate, well protective effect antioxidant ascorbic acid (AA) chemotherapy a murine model visceral BALB/c mice infected with Leishmania infantum were treated intraperitoneally at 80 mg Sb/kg/day commercial (Glu)...
Implantation of synthetic matrices and biomedical devices in diabetic individuals has become a common procedure to repair and/or replace biological tissues. However, an adverse foreign body reaction that invariably occurs adjacent implant impairing their function is poorly characterized the environment. We investigated influence this condition on abnormal tissue healing response implants placed subcutaneously normoglycemic streptozotocin-induced diabetes rats. In polyether-polyurethane...
Chronic inflammatory processes in the peritoneal cavity develop as a result of ischemia, foreign body reaction, and trauma. Brazilian green propolis, beeswax product, has been shown to exhibit multiple actions on inflammation tissue repair. Our aim was investigate effects this natural product inflammatory, angiogenic, fibrogenic components fibroproliferative induced by synthetic matrix. placing polyether-polyurethane sponge discs abdominal anesthetized Swiss mice. Oral administration...
Versican and tumor-associated macrophages (TAMs) are involved in growth metastases several cancers. Here, we investigated the potential role of versican, a matrix proteoglycan, its correlation with TAMs infiltrates different stages two breast cancer models: spontaneous canine mammary gland carcinomas murine 4T1 model. The stromal versican expression was correlated accumulation tumors an advanced stage from carcinoma samples. mice, identified late tumor progression, associated to high number...
A crucial component of the integration between foreign implants and host is angiogenesis. However, to date, none available techniques and/or endothelial markers employed assess angiogenesis in implant/host interface seems be able highlight vascular structures convincingly. In present study we investigated compared expression two cell markers: platelet adhesion molecule (PECAM-1) (CD31) endoglin (CD105) using immunohistochemistry (IHC) immunofluorescence (IF) identify quantify newly formed...
The short-chain fatty acid (SCFA) propionate, beyond its actions on the intestine, has been able to lower inflammation and modulate angiogenesis fibrogenesis in pathological conditions experimental animal models. Its effects foreign body reaction (FBR), an abnormal healing process induced by implantation of medical devices, have not investigated. We evaluated sodium propionate (SP) inflammation, neovascularization remodeling a murine model implant-induced FBR. Polyether-polyurethane sponge...
O artigo apresenta uma análise preliminar dos dados coletados a partir do edital "Prêmio Cultura Viva Construção Nacional Hip-Hop" (Seleção nº 10/2023), promovido pelo Ministério da Cultura. A iniciativa buscou mapear diversidade cultura Hip-Hop no Brasil, destacando importância dessa expressão cultural enquanto movimento de resistência e denúncia das violências que afetam as juventudes periféricas corpos negros. pesquisa foi realizada na Universidade Federal São Paulo, campus Guarulhos, em...
ABSTRACT Host responses to synthetic implants are analogous healing, the process of repair that follows injury. Normally, processes wound healing follow well‐established patterns but conditions such as autoimmune diseases profoundly affect tissue repair. We have analyzed sponge‐induced in lupus‐prone New Zealand White and control (Balb/c) mouse strains by measuring inflammation, extracellular matrix deposition, angiogenesis, cytokine production polyether–polyurethane sponge implanted...
Abstract Synthetic matrices have been used widely to repair and/or replace biological tissues. However, there is relatively little information on the effect of different anatomical compartments host response foreign implants. We analyzed such responses sponge implants in subcutaneous and intraperitoneal sites mice at days 3, 5, 8 postimplantation by measuring inflammation, angiogenesis, production proangiogenic/inflammatory cytokines. The angiogenic response, assessed hemoglobin content...
BACKGROUND AND PURPOSE Vasculopathies represent the main cause of morbidity and mortality in diabetes. Vascular malfunctioning diabetes is associated with abnormal vasoconstriction Ca 2+ handling by smooth muscle cells (SMC). Phosphatidylinositol 3‐kinases (PI3K) are key mediators insulin action have been shown to modulate function voltage‐dependent L‐type channels (Ca V 1.2). In present work, we investigated involvement PI3K signalling regulating current through 1.2 ( I Ca,L ) vascular...
To determine biological functions of platelet‐activating factor (PAF) in chronic inflammation, we have investigated the kinetics angiogenesis, inflammatory cells recruitment and cytokine production sponge‐induced granuloma wild type PAF receptor‐deficient mice (PAFR‐KO). Angiogenesis as determined by morphometric analysis hemoglobin content was significantly higher implants PAFR‐KO at all time points. Treatment with receptor antagonist UK74505 (30 mg kg −1 ) also increased angiogenesis...