A5001987797- Spectroscopy and Chemometric Analyses
- Advancements in Transdermal Drug Delivery
- Analytical Chemistry and Chromatography
- Spectroscopy Techniques in Biomedical and Chemical Research
- Essential Oils and Antimicrobial Activity
- Advanced Drug Delivery Systems
- Drug Solubulity and Delivery Systems
- Pesticide Residue Analysis and Safety
- Lipid Membrane Structure and Behavior
- Analytical Methods in Pharmaceuticals
- Biofuel production and bioconversion
- Catalysis for Biomass Conversion
- Phytochemicals and Antioxidant Activities
- Chromatography in Natural Products
- Water Quality Monitoring and Analysis
- Optimal Experimental Design Methods
- Crystallization and Solubility Studies
- Electrochemical Analysis and Applications
- Dental Anxiety and Anesthesia Techniques
- Advanced Chemical Sensor Technologies
- Anesthesia and Pain Management
- Biosimilars and Bioanalytical Methods
- Petroleum Processing and Analysis
- Food composition and properties
- Bee Products Chemical Analysis
Universidade Estadual de Campinas (UNICAMP)
2014-2024
Hospital de Clínicas da Unicamp
2021
Pontifícia Universidade Católica de Campinas
2019
In this work, a method based on ultra-high-performance liquid chromatography with photodiode array detector (UPLC-PDA) was developed to comprehensively analyze phenolic compounds in peels of lime (
Pretreatments are one of the main bottlenecks for lignocellulose conversion process and search cheaper effective pretreatment methodologies each biomass is a complex but fundamental task. Here, we used 2ν5−1 fractional factorial design (FFD) to optimize five variables: milling time, temperature, double treatment, chemical concentration, time in acid–alkali (EA) acid–organosolv (EO) pretreatments, applied elephant grass leaves. FFD allowed optimization conditions using reduced number...
Abstract Inflammatory conditions of the temporomandibular joint (TMJ) and peripheral tissues affect many people around world are commonly treated with non-steroidal anti-inflammatory drugs (NSAIDs). However, in order to get desirable results, treatments NSAIDs may take weeks, causing undesirable side effects requiring repeated administration. In this sense, work describes development an optimized nanostructured lipid carrier (NLC) formulation for intra-articular administration naproxen...
A method for sulfur determination in diesel fuel employing near infrared spectroscopy, variable selection and multivariate calibration is described. The performances of principal component regression (PCR) partial least square (PLS) chemometric methods were compared with those shown by multiple linear (MLR), performed after based on the genetic algorithm (GA) or successive projection (SPA). Ninety seven samples divided into three sets (41 calibration, 30 internal validation 26 external...
The dehydration reaction of d-(−)-fructose into 5-(hydroxymethyl)furfural (HMF) in both batch and continuous flow conditions was comprehensively studied using the statistical tool design experiments (DoE), employing i-PrOH/DMSO as solvent system presence solid acid catalyst Amberlyst-15. Initially, screening different alcohols (MeOH, EtOH, i-PrOH, t-BuOH) showed that i-PrOH provides better selectivity yield compared to other alcohols, along with minimum formation byproducts when associated...
Raman imaging spectroscopy is a relatively new technique that has raised interest in several areas of knowledge due to the possibility evaluating spatial distribution compounds based on their spectra.This paper presents brief history development this important technique, theoretical description effect and preprocessing processing (both univariate multivariate) tools for data.We also describe current state applications major such as agriculture/biomass, environment, biology, medicine,
Topical anesthetics are widely applied in order to relieve the discomfort and anxiety caused by needle insertion other painful superficial interventions at oral cavity. So far, there no commercially available effective topical anesthetic formulations for that purpose, most of developments related hydrophilic low mucoadhesive forms. Therefore, we have prepared different hybrid nanofilms composed biopolymer matrices (chitosan, pectin, chitosan-pectin) blended with nanostructured lipid carriers...
Abstract Tetracaine (TTC) is a local anesthetic broadly used for topical and spinal blockade, despite its systemic toxicity. Encapsulation in nanostructured lipid carriers (NLC) may prolong TTC delivery at the site of injection, reducing such This work reports development NLC loading 4% TTC. Structural properties encapsulation efficiency (%EE > 63%) guided selection three pre-formulations different composition, through 2 3 factorial design experiments (DOE). DLS TEM analyses revealed...
Local anesthesia in dentistry is by far the most terrifying procedure for patients, causing treatment interruption. None of commercially available topical formulations effective eliminating pain and phobia associated to needle insertion injection.In this work we prepared a nanostructured lipid-biopolymer hydrogel sustained delivery lidocaine-prilocaine (LDC-PLC) transbuccal pre-anesthesia. The lipid was composed optimized carriers (NLC) loaded with 5% LDC-PLC (NLC/LDC-PLC). biopolymer...
The local anesthetic Butamben was encapsulated in NLC and characterized.<italic>In vitro</italic>tests showed decreased cytotoxicity and<italic>in vivo</italic>it improved the anesthesia inflamed tissue.
Campylobacter jejuni (CJ) is the most prevalent zoonotic pathogen of chicken meat and related products, which may lead to gastroenteritis autoimmune diseases in humans. Although controlling this bacterium important, CJ strains resistance against traditional antibiotic therapy has been increased. Vegetable oils fats are natural biomaterials explored since Ancient times, due their therapeutic properties. Nanotechnology promoted miniaturization materials, improving bioavailability efficacy,...