A5013870534- Advanced Drug Delivery Systems
- Advancements in Transdermal Drug Delivery
- Lipid Membrane Structure and Behavior
- Drug Solubulity and Delivery Systems
- Essential Oils and Antimicrobial Activity
- Spectroscopy and Chemometric Analyses
- Spectroscopy Techniques in Biomedical and Chemical Research
- Anesthesia and Pain Management
- Nanoparticle-Based Drug Delivery
- Dental Anxiety and Anesthesia Techniques
- Antimicrobial Peptides and Activities
- Antibiotics Pharmacokinetics and Efficacy
- Hydrogels: synthesis, properties, applications
- Coagulation and Flocculation Studies
- Ocular Surface and Contact Lens
- Adsorption and biosorption for pollutant removal
- Membrane Separation Technologies
- Pediatric Pain Management Techniques
- Inhalation and Respiratory Drug Delivery
- biodegradable polymer synthesis and properties
- Surfactants and Colloidal Systems
- Migraine and Headache Studies
Universidade Estadual de Campinas (UNICAMP)
2016-2021
Abstract Inflammatory conditions of the temporomandibular joint (TMJ) and peripheral tissues affect many people around world are commonly treated with non-steroidal anti-inflammatory drugs (NSAIDs). However, in order to get desirable results, treatments NSAIDs may take weeks, causing undesirable side effects requiring repeated administration. In this sense, work describes development an optimized nanostructured lipid carrier (NLC) formulation for intra-articular administration naproxen...
The use of biomaterials composed organic pristine components has been successfully described in several purposes, such as tissue engineering and drug delivery. Drug delivery systems (DDS) have shown advantages over traditional therapy, greater therapeutic efficacy, prolonged profile, reduced toxicity, evidenced by vitro vivo studies well clinical trials. Despite that, there is no perfect carrier, issues undesirable viscosity physicochemical stability or inability to efficiently encapsulate...
Topical anesthetics are widely applied in order to relieve the discomfort and anxiety caused by needle insertion other painful superficial interventions at oral cavity. So far, there no commercially available effective topical anesthetic formulations for that purpose, most of developments related hydrophilic low mucoadhesive forms. Therefore, we have prepared different hybrid nanofilms composed biopolymer matrices (chitosan, pectin, chitosan-pectin) blended with nanostructured lipid carriers...
Abstract Tetracaine (TTC) is a local anesthetic broadly used for topical and spinal blockade, despite its systemic toxicity. Encapsulation in nanostructured lipid carriers (NLC) may prolong TTC delivery at the site of injection, reducing such This work reports development NLC loading 4% TTC. Structural properties encapsulation efficiency (%EE > 63%) guided selection three pre-formulations different composition, through 2 3 factorial design experiments (DOE). DLS TEM analyses revealed...
Local anesthesia in dentistry is by far the most terrifying procedure for patients, causing treatment interruption. None of commercially available topical formulations effective eliminating pain and phobia associated to needle insertion injection.In this work we prepared a nanostructured lipid-biopolymer hydrogel sustained delivery lidocaine-prilocaine (LDC-PLC) transbuccal pre-anesthesia. The lipid was composed optimized carriers (NLC) loaded with 5% LDC-PLC (NLC/LDC-PLC). biopolymer...
Dairy operations generate large volumes of polluted wastewater that require treatment prior to discharge. Chemically enhanced primary (CEPT) is a widely utilized strategy; but it requires the use non-biodegradable coagulants can lead toxic-byproducts. In this study, chitin from shrimp shell waste extracted and converted into chitosan. Chitosan was demonstrated be natural, low-cost alternative coagulant compatible with CEPT. Following treatment, dissolved air flotation allowed for removal...
Recent advances have been reported for needle-free local anesthesia in maxillary teeth by administering a nasal spray of tetracaine (TTC) and oxymetazoline, without causing pain, fear, stress. This work aimed to assess whether TTC-loaded hybrid system could reduce cytotoxicity, promote sustained permeation, increase the anesthetic efficacy TTC safe, effective, painless, prolonged analgesia dental procedures. The based on (4%) encapsulated nanostructured lipid carriers (NLC) incorporated into...
In the last years, advanced nanohybrid materials processed as pharmaceuticals have proved to be very advantageous. Triptans, such commercially available intranasal sumatriptan (SMT), are drugs employed in treatment of migraine painful symptoms. However, SMT effectiveness is limited by its high hydrophilicity and poor mucoadhesion. Therefore, we designed hybrid nanoemulsions (NE) composed copaiba oil organic component biopolymers (xanthan, pectin, or alginate) continuous aqueous phase, aiming...
Abstract BACKGROUND A new role as an antitumoral agent has been proposed for the local anesthetic bupivacaine (BVC), considering its toxic effects on cancer cells. However, such drug repositioning requires improvement in available concentrations and sustained release profiles to surpass BVC short action narrow therapeutic window. Nanostructured lipid carriers (NLC) may provide with release, they can be formulated essential oils, whose intrinsic properties act synergistically BVC. This study...
Bupivacaine is the most used local anesthetic in surgical procedures, producing prolonged anesthesia. The major limiting factor for clinical use of bupivacaine comes from its systemic toxicity. Nanostructured lipid carriers (NLC) are vehicles sustained drug delivery that able to minimize toxicity and increase action time lipophilic drugs.This work reports a 22 factorial design, which elucidates role lipids mixture NLC, towards an optimized formulation. It also provides new method S75:R25...
Ciprofloxacin (CIP), a broad spectrum antibacterial agent from the fluoroquinolone family, blocks activity of bacterial DNA gyrase. CIP has limited aqueous solubility and fast clearance rate. Nanostructured lipid carriers (NLC) are drug delivery very appropriate to upload hydrophobic drugs, improving their bioavailability, stability potency. This work describes development NLC containing CIP, physicochemical characterization antimicrobial activity, in vitro. particles (215-355 nm) low size...