A5069694528- Advanced Drug Delivery Systems
- Advancements in Transdermal Drug Delivery
- Dental Anxiety and Anesthesia Techniques
- Anesthesia and Pain Management
- Drug Solubulity and Delivery Systems
- Pediatric Pain Management Techniques
- Anesthesia and Sedative Agents
- Dermatology and Skin Diseases
- Dental Erosion and Treatment
- Lipid Membrane Structure and Behavior
- Ocular Surface and Contact Lens
- Nanoparticle-Based Drug Delivery
- Oral microbiology and periodontitis research
- Veterinary Pharmacology and Anesthesia
- Pain Mechanisms and Treatments
- Salivary Gland Disorders and Functions
- Medicinal plant effects and applications
- Complementary and Alternative Medicine Studies
- Public Health in Brazil
- Anesthesia and Neurotoxicity Research
- Dental Trauma and Treatments
- Analytical Chemistry and Chromatography
- Herbal Medicine Research Studies
- Streptococcal Infections and Treatments
- Oral and Maxillofacial Pathology
Universidade Estadual de Campinas (UNICAMP)
2015-2024
Brazilian Biosciences National Laboratory
2022
Methodist University of Piracicaba
2012-2020
Universidade Federal do ABC
2014
Universidade Federal do Pará
2008
Fundação Faculdade de Odontologia
2006
Objective: The aim of the present study was to encapsulate vancomycin in different liposomal formulations and compare vitro antimicrobial activity against Staphylococcus aureus biofilms. Methods: Large unilamellar vesicles conventional (LUV VAN), fusogenic (LUVfuso cationic (LUVcat VAN) liposomes encapsulating VAN were characterized terms size, polydispersity index, zeta potential, morphology, encapsulation efficiency (%EE) release kinetics. tested for their Minimum Inhibitory Concentration...
Objective: To characterize liposomal-lidocaine formulations for topical use on oral mucosa and to compare their in vitro permeation vivo anesthetic efficacy with commercially available lidocaine formulations.Materials methods: Large unilamellar liposomes (400 nm) containing were prepared using phosphatidylcholine, cholesterol, α-tocoferol (4:3:0.07, w:w:w) characterized terms of membrane/water partition coefficient, encapsulation efficiency, size, polydispersity, zeta potential, release. In...
This study reports the development of nanostructured hydrogels for sustained release eutectic mixture lidocaine and prilocaine (both at 2.5%) intraoral topical use. The local anesthetics, free or encapsulated in poly(ε-caprolactone) nanocapsules, were incorporated into CARBOPOL hydrogel. nanoparticle suspensions characterized vitro terms particle size, polydispersity, surface charge, using dynamic light scattering measurements. concentrations determined by tracking analysis. Evaluation was...
The use of biomaterials composed organic pristine components has been successfully described in several purposes, such as tissue engineering and drug delivery. Drug delivery systems (DDS) have shown advantages over traditional therapy, greater therapeutic efficacy, prolonged profile, reduced toxicity, evidenced by vitro vivo studies well clinical trials. Despite that, there is no perfect carrier, issues undesirable viscosity physicochemical stability or inability to efficiently encapsulate...
In Brief BACKGROUND: The elimination of pain caused by needle insertion for local anesthesia would be a significant advance in dentistry. METHODS: this blinded cross-over study we evaluated the efficacy liposome-encapsulated ropivacaine topical anesthesia. Thirty healthy volunteers received 60 mg anesthetics: Liposome-encapsulated 1% ropivacaine, plain 2.5% lidocaine and prilocaine mixture (EMLA), 20% benzocaine gel, buccal fold upper-right canine 2 min different sessions. After 30-G...
In Brief BACKGROUND: Bupivacaine (BVC) and ropivacaine (RVC) are local anesthetics widely used in surgical procedures. previous studies, inclusion complexes of BVC or RVC hydroxypropyl-β-cyclodextrin (HP-β-CD) increased differential nervous blockade, compared to the plain anesthetic solutions. this study we evaluated neural muscular toxicity these new formulations containing 0.5% complexed with HP-β-CD (BVCHP-β-CD RVCHP-β-CD). METHODS: Schwann cell viability was assessed by determination...
To develop an anesthetic mucoadhesive film containing Acmella oleracea (jambu) extract for topical use on oral mucosa.Ethanolic extracts from aerial parts of jambu were prepared by maceration. Pigment removal was obtained adsorption with activated carbon. Three films developed using a casting method: 10 or 20% crude (10% JB and JB), 10% treated carbon JBC). The characterized regarding their uniformity, thickness, pH, spilanthol content, stability evaluated during 120 days. Gas chromatography...
Topical anesthetics are widely applied in order to relieve the discomfort and anxiety caused by needle insertion other painful superficial interventions at oral cavity. So far, there no commercially available effective topical anesthetic formulations for that purpose, most of developments related hydrophilic low mucoadhesive forms. Therefore, we have prepared different hybrid nanofilms composed biopolymer matrices (chitosan, pectin, chitosan-pectin) blended with nanostructured lipid carriers...
Local anesthesia in dentistry is by far the most terrifying procedure for patients, causing treatment interruption. None of commercially available topical formulations effective eliminating pain and phobia associated to needle insertion injection.In this work we prepared a nanostructured lipid-biopolymer hydrogel sustained delivery lidocaine-prilocaine (LDC-PLC) transbuccal pre-anesthesia. The lipid was composed optimized carriers (NLC) loaded with 5% LDC-PLC (NLC/LDC-PLC). biopolymer...
To investigate the associations among salivary bacteria, oral emanations of volatile sulfur compounds, and academic-related chronic stress in healthy male subjects.Seventy-eight undergraduate dental students were classified as stressed or not by evaluation burnout, a syndrome attributed to stress. This was carried out using Maslach Burnout Inventory-Student Survey questionnaire. Oral hydrogen sulfide, methyl mercaptan, dimethyl sulfide measured an Chroma™ portable gas chromatograph. The...
Topical drug administration offers an attractive route with minimal invasiveness. It also avoids limitations of intravenous such as the first pass metabolism and presystemic elimination within gastrointestinal tract. Furthermore, topical is safe, have few side effects, easy to apply, a fast onset action. However, development effective formulations still represents challenge for desired effect be reached, locally or systemically. Solid lipid nanoparticles nanostructured carriers are...
Lidocaine is the most commonly used local anesthetic worldwide, known for its rapid onset and moderate duration of anesthesia. However, it short-lived does not effectively promote effective topical anesthesia in oral cavity when alone. Our aim was to investigate whether an approximate 50% encapsulation lidocaine poly(ε-caprolactone) nanocapsules (LDC-Nano) would be able increase permeation analgesic efficacy reduce cytotoxicity. In this study, we characterized LDC-Nano conducted MTT tests...
As of 2023, more than 200 million people worldwide are living with osteoporosis. Oral bisphosphonates (BPs) the primary treatment but can cause gastrointestinal (GI) side effects, reducing patient compliance. Microarray (MAP) technology has potential to overcome GI irritation by facilitating transdermal delivery BPs. This study examines alendronic acid (ALN) and risedronate sodium (RDN) using dissolving hydrogel-forming MAPs for osteoporosis treatment. In vivo testing on osteoporotic female...