A5056245195- Advancements in Transdermal Drug Delivery
- Nanoparticle-Based Drug Delivery
- Dermatology and Skin Diseases
- Retinoids in leukemia and cellular processes
- Advanced Drug Delivery Systems
- Lipid Membrane Structure and Behavior
- Phytochemical compounds biological activities
- Bee Products Chemical Analysis
- Proteins in Food Systems
- Piperaceae Chemical and Biological Studies
- Ocular Surface and Contact Lens
- Sphingolipid Metabolism and Signaling
- Heavy Metal Exposure and Toxicity
- Graphene and Nanomaterials Applications
- Essential Oils and Antimicrobial Activity
- Business and Management Studies
- Nanoplatforms for cancer theranostics
- Selenium in Biological Systems
- Antifungal resistance and susceptibility
- Antimicrobial Peptides and Activities
- Biochemical and Structural Characterization
- Allergic Rhinitis and Sensitization
- Science and Science Education
- Acute Lymphoblastic Leukemia research
- Toxic Organic Pollutants Impact
Universidade de São Paulo
2018-2023
Nanomed (Brazil)
2020
Universidade Estadual Paulista (Unesp)
2019
Considering that breast cancer usually begins in the lining of ducts, local drug administration into ducts could target cancers and pre-tumor lesions locally while reducing systemic adverse effects. In this study, a cationic bioadhesive nanoemulsion was developed for intraductal C6 ceramide, sphingolipid mediates apoptotic non-apoptotic cell death. Bioadhesive properties were obtained by surface modification with chitosan. The optimized displayed size 46.3 nm positive charge, not affected...
As a new strategy for treatment of ductal carcinoma in situ, biocompatible and bioadhesive nanoemulsions intraductal administration the cytotoxic agent piplartine (piperlongumine) were optimized this study. To confer properties, nanoemulsion was modified with chitosan or hyaluronic acid. Tricaprylin selected as non-polar phase due to its ability dissolve larger drug amounts compared isopropyl myristate monocaprylin. Use phosphatidylcholine sole surfactant did not result homogeneous...
Topical drug administration is frequently used for the treatment of vaginal candidiasis; however, most formulations using this route do not provide prolonged release. Our aim was to evaluate antifungal efficacy amphotericin B (AMB) and miltefosine (MFS) incorporated in nanocarriers sustained release, a murine model candidiasis. AMB MFS were different topical formulations, namely: conventional cream (daily dose 6 days; MFS-CR AMB-CR groups), microemulsion that transforms into liquid...
The need of pharmacological strategies to preclude breast cancer development motivated us develop a non-aqueous microemulsion (ME) capable forming depot after administration in the mammary tissue and uptake interstitial fluids for prolonged release retinoid fenretinide. selected ME was composed phosphatidylcholine/tricaprylin/propylene glycol (45:5:50, w/w/w) presented droplet diameter 175.3 ± 8.9 nm. Upon water uptake, transformed successively into lamellar phase, gel, phase-containing...
The purpose of this study was to evaluate the effect composition and characteristics liquid crystalline phases (LCPs) on cutaneous delivery methylene blue (MB). LCPs were obtained by mixing Brij97® with water at various ratios; Brij97®:water 8:2 (F8:2), 7:3 (F7:3), 6:4 (F6:4) selected, MB incorporated 0.1%. F8:2 F7:3 exhibited textures small angle X-ray scattering (SAXS) patterns corresponding lamellar phase, whereas F6:4 displayed hexagonal phase. All three stable for 9 months, thixotropic...
Limitations of conventional treatment and dosage forms prompted the investigation novel approaches that combine efficacy, selectivity fewer adverse effects.These are main promises nanomedicine, generally defined as application nanotechnology to biomedical field.Despite considerable advances over years large number publications resulting from growth there still many hurdles unknown factors limiting its successful translation promise reality.These range lack standardization in terminology...
In this study, incorporation of the cytotoxic agent paclitaxel and P-glycoprotein inhibitor elacridar in hyaluronic acid (HA)-modified nanoemulsions was studied for intraductal delivery breast cancer localized treatment. To improve cytotoxicity, we investigated perillyl alcohol or tributyrin as components nanoemulsion oil phase. The presented size <180 nm negative zeta potential. Both increased cytotoxicity MCF-7 cells, but not MDA-MB-231. However, reduced stability presence drugs....
Seriniquinone (SQ) was initially described by our group as an antimelanoma drug candidate and now also antifungal candidate. Despite its promising in vitro effects, SQ translation has been hindered poor water-solubility. In this paper, we the challenging nanoformulation process of SQ, which culminated selection a phosphatidylcholine-based lamellar phase (PLP1). Liposomes nanostructured lipid carriers were evaluated but failed to encapsulate compound. SQ-loaded PLP1 (PLP1-SQ) characterized...
This study evaluated raloxifene (ral) effects on LNCaP prostate tumour cells modulating the activity of GPER1/GPR30 receptors.LNCaP were submitted for 40/120 min and 12 h to following treatments: C: RPMI + DMSO; R: Ral; G: Ral G15 (GPER1 antagonist). Trypan blue staining measured cell viability. Migratory potential (12 h) was by transwell migration test in translucent inserts, which then stained with DAPI analysed under a fluorescence microscope quantification. Cells from 40- 120-min...
Abstract: In the past decades, nanocarriers have attracted attention as topical delivery systems for many compounds employed in cosmetic field. This interest is justified by their ability to pro-vide protection against degradation of liable molecules, possibility originate a local depot and prolong drug release, overcome barrier function skin co-encapsulation varying physicochemical characteristics. The properties vary with composition structure, which, turn, influence outcomes treatment....