A5049736659- Fungal Infections and Studies
- Antifungal resistance and susceptibility
- Plant-Microbe Interactions and Immunity
- Plant Disease Resistance and Genetics
- Plant Pathogens and Fungal Diseases
- Toxin Mechanisms and Immunotoxins
- Nail Diseases and Treatments
- Antimicrobial Peptides and Activities
- Studies on Chitinases and Chitosanases
- Phytochemical compounds biological activities
- Bee Products Chemical Analysis
- Infectious Diseases and Mycology
- Pineapple and bromelain studies
- Medical and Biological Ozone Research
- Microbial Metabolism and Applications
- Plant Disease Management Techniques
- Actinomycetales infections and treatment
- Medicinal Plants and Neuroprotection
- Nematode management and characterization studies
- Insect and Pesticide Research
- Diverse Scientific Research Studies
- Chemical Synthesis and Analysis
- Insect Pest Control Strategies
- Research on Leishmaniasis Studies
- Organoboron and organosilicon chemistry
Universidade de São Paulo
2017-2024
Instituto Butantan
2021
Universidade Federal do Rio Grande do Sul
2013-2016
University of Cruz Alta
2014
Previous studies indicate that miltefosine (MFS) may be an alternative as antifungal agent; however, it presents several adverse effects. Thus, the aim of this study was to produce miltefosine-loaded alginate nanoparticles (MFS.Alg) for toxicity reduction used treatment cryptococcosis and candidiasis.Alginate were produced using external emulsification/gelation method, their physicochemical morphological characteristics analyzed. MFS encapsulation efficiency, release assay on red blood cells...
Cryptococcus spp. are common opportunistic fungal pathogens, particularly in HIV patients.
Topical drug administration is frequently used for the treatment of vaginal candidiasis; however, most formulations using this route do not provide prolonged release. Our aim was to evaluate antifungal efficacy amphotericin B (AMB) and miltefosine (MFS) incorporated in nanocarriers sustained release, a murine model candidiasis. AMB MFS were different topical formulations, namely: conventional cream (daily dose 6 days; MFS-CR AMB-CR groups), microemulsion that transforms into liquid...
Abstract Objectives To develop alginate nanoparticles functionalized with polysorbate 80 (P80) as miltefosine carriers for brain targeting in the oral treatment of cryptococcal meningitis. Methods Miltefosine-loaded or not P80 were produced by an emulsification/external gelation method and physicochemical characteristics determined. The haemolytic activity cytotoxic antifungal effects assessed vitro model blood–brain barrier (BBB). A murine disseminated cryptococcosis was used testing...
Vulvovaginal and invasive candidiasis are frequent conditions in immunosuppressed individuals caused by Candida albicans non-albicans spp. Fluconazole Amphotericin B the main drugs used to fight infection. However, resistance fluconazole other azole antifungal is an important clinical problem that encourages search for new therapeutic alternatives. In this work, we evaluate activity of biphosphinic cyclopalladate C7a vitro vivo model. Our results showed fungicidal activity, with low values...
Spot blotch disease, caused by Bipolaris sorokiniana, is one of the major diseases wheat and responsible for large losses crops worldwide. We used polymerase chain reaction (PCR) with universal rice primers (URP) molecular characterization 60 monosporic B. sorokiniana isolates from Brazil other countries, evaluated diversity samples. PCR amplification generated 232 different DNA fragments ranging in size 100 to 2018 bp. The URP-4R, URP-2R, URP-1F greater numbers amplified (36, 30, 25,...
Cryptococcosis therapy is often limited by toxicity problems, antifungal tolerance, and high costs. Studies approaching chalcogen compounds, especially those containing selenium, have shown promising activity against pathogenic species. This work aimed to evaluate the in vitro vivo potential of organoselenium compounds Cryptococcus neoformans. The lead compound LQA_78 had an inhibitory effect on C. neoformans planktonic cells dispersed from mature biofilms at similar concentrations. fungal...
The escalating prevalence of fungal infections, coupled with the limitations and adverse effects associated existing antifungal drugs, necessitates exploration alternative therapeutic approaches. objective this study was, therefore, to conduct a chemical analysis assess biological potential hydroethanolic extract obtained from leaves Machaerium villosum. Thus, investigates plant, which belongs Fabaceae family, known for its rich flavonoid content. Employing UHPLC-ESI-IT-MS/MS, was...
Bipolaris sorokiniana may present considerable genetic diversity and highly variable pathogenicity virulence. The of 99 B. isolates (27 polysporic 72 monosporic isolates) from Brazil other countries was assessed. Based on aborted germination, black point seed, leaf spot, coleoptile lesion, the principal component analysis (PCA) used to evaluate similarity patterns between considering variables pathogenicity. Polysporic presented higher virulence (over 60%), when compared with (43%) for all...
Actinobacteria secrete substances that limit or inhibit the growth of plant pathogenic fungi and may be used in biocontrol these microorganisms. The aim this study was to characterize physiological enzymatic activity endophytic actinobacteria, evaluate their antifungal against Bipolaris sorokiniana root colonization, efficiency promoting wheat seedlings. Antibiosis analyzed using double-layer method, agar well diffusion test, volatile metabolites. Physiological evaluated through chitinase,...