A5034766649- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Synthesis and biological activity
- Research on Leishmaniasis Studies
- Allelopathy and phytotoxic interactions
- Essential Oils and Antimicrobial Activity
- Synthesis and Characterization of Heterocyclic Compounds
- Click Chemistry and Applications
- Fungal Plant Pathogen Control
- Trypanosoma species research and implications
- Mosquito-borne diseases and control
- Insect Pest Control Strategies
- Synthesis and Biological Evaluation
- Phytochemistry Medicinal Plant Applications
- Chemical synthesis and alkaloids
- Synthetic Organic Chemistry Methods
- Synthesis of Organic Compounds
- Weed Control and Herbicide Applications
- Computational Drug Discovery Methods
- Psidium guajava Extracts and Applications
- Synthesis and Reactions of Organic Compounds
- Traditional and Medicinal Uses of Annonaceae
- HIV/AIDS drug development and treatment
- Biological Activity of Diterpenoids and Biflavonoids
- Phytochemical compounds biological activities
Universidade Federal de Viçosa
2015-2024
Centro Universitário do Norte
2024
Amazon (United States)
2024
Universidade Estadual Paulista (Unesp)
2024
Essa Pharma (United States)
2024
Universidade Federal de Minas Gerais
2006-2024
Brazilian National Association of Graduate Programs in Communication
2023-2024
Universidade Federal do Ceará
2021
Universidade Federal de Goiás
2018
Centro Universitário de Belo Horizonte
2016
The concentration and the chemical composition of essential oils obtained from different samples Cymbopogon citratus were evaluated. Among 12 investigated (11 dried leaf fresh plant leaves), seven presented oil concentrations within threshold established by Brazilian legislation. moisture content was also determined majority humidity contents near 12%. GC GC/MS analyses led to identification 22 compounds, with neral geranial as two major components. total percentage these compounds varied...
Dysregulation of pre-mRNA splicing machinery activity has been related to the biogenesis several diseases. The serine/arginine-rich protein kinase family (SRPKs) plays a critical role in regulating events through extensive phosphorylation factors from proteins (SR proteins). Previous investigations have described overexpression SRPK1 and SRPK2 leukemia other cancer types, suggesting that they would be useful targets for developing novel antitumor strategies. Herein, we evaluated effect...
Melanoma is the most aggressive skin cancer, and its incidence has continued to rise during past decades. Conventional treatments present severe side effects in cancer patients, melanoma can be refractory commonly used anticancer drugs, which justify efforts find new potential anti-melanoma drugs. An alternative promote discovery of pharmacological substances would modifying chemical groups from a bioactive compound. Here we describe synthesis seventeen compounds derived cinnamic acid their...
Vanillin is the main component of natural vanilla extract and responsible for its flavoring properties. Besides well-known applications as an additive in food cosmetics, it has also been reported that vanillin can inhibit fungi clinical interest, such Candida spp., Cryptococcus Aspergillus well dermatophytes. Thus, present work approaches synthesis a series derivatives with 1,2,3-triazole fragments evaluation their antifungal activities against albicans, glabrata, parapsilosis, tropicalis,...
Thirteen triazole derivatives bearing halogenated benzyl substituents were synthesized using the Cu-catalyzed azide-alkyne cycloaddition (CuAAC), a leading example of click chemistry approach, as key step. The biological activity compounds was evaluated, and it found that these interfere with germination radicle growth (shoots roots) two dicotyledonous species, Lactuca sativa Cucumis sativus, one monocotyledonous Allium cepa. showed predominantly inhibitory related to evaluated species...
Dengue is a neglected disease, one that responsible for 22,000 deaths each year in areas where it endemic. Despite the tremendous efforts invested research dengue treatments, no vaccine or antiviral has reached market, and disease treatment limited to supportive care. Among strategies have been used search development of an against dengue, inhibition viral enzymes proven be most successful approach. This review covers major progresses published concerning compounds inhibit enzymes.
Butenolides, five membered α,&946;-unsaturated γ-lactones, are ubiquitous moieties present in the structures of many natural products and synthetic compounds endowed with a large array biological activities. Butenolides an γ-alkylidene moiety termed as γ-alkylidenebutenolides. Because their chemical well activities, butenolides have attracted attention organic chemistry community. As consequence, several methodologies been developed to synthesize these classes compounds. The potential use...
The synthesis of a series 1,2,3-triazoles using glycerol as starting material is described. key step in the preparation these triazolic derivatives copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC), also known click reaction, between 4-(azidomethyl)-2,2-dimethyl-1,3-dioxolane (3) and different terminal alkynes. eight prepared were evaluated with regard to their fungicide, phytotoxic cytotoxic activities. fungicidal activity was assessed vitro against Colletotrichum gloeosporioides,...
A series of 34 3-benzyl-5-(arylmethylene)furan-2(5H)-ones, designed using the naturally occurring toxins nostoclides as a lead structure, was synthesized potential inhibitors photosynthetic electron transport. All compounds were fully characterized by IR, NMR (1H and 13C), MS spectrometry. HMBC HSQC bidimensional experiments allowed 13C 1H assignments. Their biological activities evaluated in vitro ability to interfere with light-driven reduction ferricyanide isolated spinach chloroplasts....
A series of thirteen C-3 functionalized isobenzofuran-1(3H)-ones (phtalides) was synthesized via condensation, aromatization, and acetylation reactions. NMR (one two dimensional experiments), IR, mass spectrometry analysis allowed confirmation the identity compounds. The substances were submitted to in vitro bioassays against U937 (lymphoma) K562 (myeloid leukemia) cancer cell lines using MTT cytotoxicity assay. Some derivatives inhibited 90% viability at 100 µM. Also, phtalides presented...
3-Benzyl-furan-2(5H)-one (2a) and 3-(4-bromobenzyl)-furan-2(5H)-one (2b) were treated with TBDMSOTf converted into the corresponding tert-butyldimethyl-silylfuran ethers. These furans further condensed several aromatic aldehydes affording compounds 5-14 general 3-benzyl-5-arylidene-furan-2(5H)-one structures in 31% to 98% yields. Such are analogues of naturally occurring nostoclide lactones, reported present moderate cytotoxic activity. Compounds submitted an vitro bioassay against HL-60,...
The West Nile Virus (WNV) NS2B-NS3 protease is an attractive target for the development of therapeutics against this arboviral pathogen. In present investigation, screening a small library fifty-eight synthetic compounds NS2-NB3 WNV described. following groups were evaluated: 3-(2-aryl-2-oxoethyl)isobenzofuran-1(3H)-ones; eugenol derivatives bearing 1,2,3-triazolic functionalities; and indan-1,3-diones with functionalities. most promising these was derivative, namely...
Aim: Discovery of novel SARS-CoV-2 main protease (Mpro) inhibitors using a structure-based drug discovery strategy. Materials & methods: Virtual screening employing covalent and noncovalent docking was performed to discover Mpro inhibitors, which were subsequently evaluated in biochemical cellular assays. Results: 91 virtual hits selected for assays, four confirmed as reversible SARS CoV-2 with IC50 values 0.4–3 μM. They also shown inhibit SARS-CoV-1 human cathepsin L. Molecular dynamics...
A series of 19 novel eugenol derivatives containing a 1,2,3-triazole moiety was synthesized via two-step process, with the key step being copper(I)-catalyzed azide–alkyne cycloaddition reaction. The compounds were assessed for their antifungal activities against Colletotrichum gloeosporioides, causative agent papaya anthracnose. Triazoles 2k, 2m, 2l, and 2n, at 100 ppm, most effective, reducing mycelial growth by 88.3, 85.5, 82.4, 81.4%, respectively. Molecular docking calculations allowed...