Margareth de Fátima Formiga Melo Diniz

ORCID: 0000-0001-9896-9044
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About
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Research Areas
  • Phytochemistry Medicinal Plant Applications
  • Essential Oils and Antimicrobial Activity
  • Traditional and Medicinal Uses of Annonaceae
  • Ethnobotanical and Medicinal Plants Studies
  • Agricultural and Food Sciences
  • Alkaloids: synthesis and pharmacology
  • Berberine and alkaloids research
  • Piperaceae Chemical and Biological Studies
  • Phytochemistry and Biological Activities
  • Pharmacological Effects of Natural Compounds
  • Synthesis and biological activity
  • Complementary and Alternative Medicine Studies
  • Healthcare Regulation
  • Phytochemical compounds biological activities
  • Ginseng Biological Effects and Applications
  • Occupational Health and Burnout
  • Public Health in Brazil
  • Natural Antidiabetic Agents Studies
  • Liver Disease Diagnosis and Treatment
  • Bee Products Chemical Analysis
  • Phytochemistry and Bioactivity Studies
  • Pharmacology and Obesity Treatment
  • Helicobacter pylori-related gastroenterology studies
  • Healthcare during COVID-19 Pandemic
  • Chemical synthesis and alkaloids

Universidade Federal da Paraíba
2016-2025

Universidade Estadual da Paraíba
2002-2024

Universidade Federal de Ouro Preto
2022-2024

Universidade Federal de Campina Grande
2019-2024

Centro Universitário de João Pessoa
2017-2024

Universidade Federal de Pernambuco
2024

Universidade de São Paulo
2018

Creative Research Enterprises (United States)
2017

Hospital Universitário Lauro Wanderley
2009

Universidade Federal de São Paulo
2009

This study was led with the purpose of evaluating effectiveness eugenol, beta-pinene and alpha-pinene in inhibiting growth potential infectious endocarditis causing gram-positive bacteria. The phytochemicals Minimum Inhibitory Concentration-MIC determined by solid medium diffusion procedure, while interference MIC values on bacterial cell viability performed viable cells count. Staphylococcus aureus, S. epidermidis, Streptococcus pneumoniae pyogenes strains were used as test microorganisms....

10.1590/s1516-93322007000100015 article EN Revista Brasileira de Ciências Farmacêuticas 2007-03-01

There has been marked interest in recent years the use of plants for treatment diabetes. Plants have found many countries which indicated as having hypoglycemic activity. The present work is an up-to-date review with 178 references crude plant extracts and chemically defined molecules activity from South, Central North America. refers to 224 their families, parts used type extract, organism tested It also includes 40 compounds isolated those plants. Some aspects research natural products...

10.1590/s0102-695x2005000400021 article EN cc-by-nc-nd Revista Brasileira de Farmacognosia 2005-12-01

The traditional use of essential oils in aromatherapy has offered numerous health benefits. However, few scientific studies have been conducted with these to confirm their therapeutic efficacy. (+)-Limonene is a chemical constituent various bioactive oils. present study reports on the anxiolytic-like effects (+)-limonene an elevated maze model anxiety mice. At concentrations 0.5% and 1.0%, (+)-limonene, administered mice by inhalation, significantly modified all parameters evaluated plus...

10.1016/j.pbb.2012.09.005 article EN publisher-specific-oa Pharmacology Biochemistry and Behavior 2012-09-18

In this study, the minimal inhibitory concentration (MIC), fungicidal (MFC) and mode of action carvacrol were determined. MIC was determined according to standard broth microdilution method, MFC taken as lowest in culture plates with Sabouraud dextrose agar, at which growth less than 3 CFU. The effect ergosterol or sorbitol on investigated using method. 256 μg/mL 512 μg/mL. This phytoconstituent acts by binding sterols fungal membrane does not act modifying cell wall. study is important...

10.1080/10412905.2012.754728 article EN Journal of Essential Oil Research 2013-01-21

The bone marrow aspiration procedure is used in hematological diseases and consists of a painful, invasive causing anxiety‐associated symptoms. present study assessed the effect Citrus aurantium L. essential oil on treatment anxiety, moment that precedes collection medullary material patients with chronic myeloid leukemia (CML). Volunteers from both sexes were divided into groups receiving either C. through inhalation , diazepam (10 mg), or placebo. evaluation was performed psychometric...

10.1002/ptr.5566 article EN Phytotherapy Research 2016-01-20

Leprosy is a chronic infectious disease caused by Mycobacterium leprae bacillus. It was considered to be an incurable for ages. Nowadays leprosy vanishing although we can meet it principally in the tropical zone countries. Brazil has second greatest number of cases around world with almost 30,000 new diagnosed 2005. The present work constitutes literature review on plant extracts and chemically defined molecules natural origin showing antileprotic activity. refers 11 plants, their families,...

10.1590/s0102-695x2007000100022 article EN cc-by-nc-nd Revista Brasileira de Farmacognosia 2007-03-01

O objetivo desta pesquisa foi realizar um estudo etnobotânico sobre a indicação de plantas medicinais para tratamentos patologias bucais, bem como investigar o uso entre usuários serviços odontológicos na cidade João Pessoa, Brasil. levantamento consistiu em duas etapas investigação: raizeiros (n = 20) e 200). Foi aplicado formulário aos fim saber quais são mais comercializadas problemas bucais. Posteriormente, dirigido serviço público 100) particular com obter informações utilização...

10.1590/s0102-695x2009000200024 article PT cc-by-nc-nd Revista Brasileira de Farmacognosia 2009-03-01

Acute Otitis Externa is an inflammation of the outer auditory meatus, and according to popular saying, medicinal plant extracts can be used in its treatment.to assess vitro antimicrobial activity following plants: Aleolanthus suaveolens; Caryophyllus aromaticus; Cymbopogon citratus; Matricaria chamomila; Pithecellobium avaremotemo; Plectranthus amboinicus Ruta graveolens on germs that cause otitis externa.the minimum inhibitory concentration oils from these plants was obtained externa...

10.1016/s1808-8694(15)30761-8 article EN cc-by Brazilian Journal of Otorhinolaryngology 2008-01-01

Malaria is a human parasitic disease caused by protozoa species of the Plasmodium genus. This has affected populations tropical and subtropical regions. About 500 million new cases occur annually on world therefore it considered an emerging important public health problem. In this context, natural products as vegetables have their bioactive molecules targets for pharmacological, toxicological phytochemical studies towards development more effective medicines treatment many diseases. So work...

10.1590/s0102-695x2009000100026 article EN cc-by-nc-nd Revista Brasileira de Farmacognosia 2009-03-01

A study with the yellow passion fruit peel flour showed positive action in blood glucose control as therapies' adjuvant patients type 2 diabetes mellitus. Therefore, we evaluated its effect on insulin sensitivity since there is a quest for studies that focus at better understanding of resistance aspects diabetic patients. Furthermore relationship chronic complications can also give good prospects alternative treatments. total 43 volunteers (28 females and 15 males) ingested 30 g/day two...

10.1186/1475-2891-11-89 article EN cc-by Nutrition Journal 2012-10-22

The aim of the present work was to develop a biochemical, histologic and immunohistochemical study about potential hepatotoxic effect d-limonene – component volatile oils extracted from citrus plants. Blood alkaline phosphatase (ALP), aspartate aminotransferase (AST) alanine (ALT) d-limonene-treated animals were determined compared morphologic hepatic lesions in order investigate possible physiopathologic mechanisms involved liver toxicity, experimental treated with d-limonene. Wistar rats...

10.1016/j.toxrep.2015.01.001 article EN cc-by-nc-nd Toxicology Reports 2015-01-01

Background/Objectives: Lauric acid (LA), a medium-chain fatty acid, is promising drug for asthma treatment. This study evaluated the toxicity of repeated doses and effect LA on pulmonary ventilation tracheal reactivity in asthmatic Wistar rats identified possible molecular targets action silico. Methods: The were divided into control (CG) LA-treated groups at 100 mg/kg (AL100G) analysis. Pulmonary assessed (CG), (AG), treated with 25, 50, or (AAL25G, AAL50G, AAL100G), dexamethasone-treated...

10.3390/ph18020221 article EN cc-by Pharmaceuticals 2025-02-06

The Brazilian polyherbal formulation (BPF) is composed by dyes of Eucalyptus globulus Labill, Peltodon radicans Pohl and Schinus terebinthifolius Raddi in alcohol at 13.3° GL. popularly used Paraíba state, Brazil since 1889 it as an antiseptic anti-inflammatory medicine. aim this study was to evaluate the property formulation. For purpose the12-O-tetradecanoylphorbol 13-acetate (TPA) capsaicin-induced mouse ear edema carrageenan-induced rat paw edema. BPF dose 26 mL/Kg inhibited both...

10.1590/s0102-695x2007000100006 article EN cc-by-nc-nd Revista Brasileira de Farmacognosia 2007-03-01

Garlic has a wide range of actions, including antibacterial, antiviral, antifungal, antiprotozoal and anthelmintic actions. This antiparasitic activity been attributed to allicin, which is the main constituent garlic. The present study aimed investigate in vitro allicin on tegument adult Schistosoma mansoni worms using scanning electron microscopy.Swiss Webster mice were infected with S. cercariae (100 per mouse) sacrificed 50 days later acquire worms. These collected by perfusion placed...

10.1590/s0037-86822011005000023 article EN cc-by Revista da Sociedade Brasileira de Medicina Tropical 2011-04-29
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