A5020032588- Pain Mechanisms and Treatments
- Alkaloids: synthesis and pharmacology
- Neuroscience and Neuropharmacology Research
- Essential Oils and Antimicrobial Activity
- Phytochemistry and Biological Activities
- Nuclear Receptors and Signaling
- Berberine and alkaloids research
- Ethnobotanical and Medicinal Plants Studies
- Diet, Metabolism, and Disease
- SARS-CoV-2 and COVID-19 Research
- Evasion and Academic Success Factors
- Liver Disease Diagnosis and Treatment
- Nigella sativa pharmacological applications
- Phytochemistry Medicinal Plant Applications
- COVID-19 Clinical Research Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Healthcare Regulation
- Bioactive Compounds and Antitumor Agents
- Pharmacology and Obesity Treatment
- Long-Term Effects of COVID-19
- Metabolism and Genetic Disorders
Universidade Federal da Paraíba
2008-2021
Hospital Universitário Lauro Wanderley
2021
(−)-Carvone is a monoterpene ketone that the main active component of Mentha plant species like spicata. This study aimed to investigate antinociceptive activity (−)-carvone using different experimental models pain and whether such effects might be involved in nervous excitability elicited by others monoterpenes. In acetic acid-induced writhing test, we observed (−)-carvone-treated mice exhibited significant decrease number writhes when 100 200 mg/kg was administered. It also demonstrated...
The aim of the present work was to develop a biochemical, histologic and immunohistochemical study about potential hepatotoxic effect d-limonene – component volatile oils extracted from citrus plants. Blood alkaline phosphatase (ALP), aspartate aminotransferase (AST) alanine (ALT) d-limonene-treated animals were determined compared morphologic hepatic lesions in order investigate possible physiopathologic mechanisms involved liver toxicity, experimental treated with d-limonene. Wistar rats...
Abstract Farnesol, a sesquiterpene alcohol, has been shown to have antioxidant and anti‐inflammatory properties. Recent studies found that compounds may exert certain protective effect against neurotoxicity. The objective of this study was evaluate the antinociceptive activity farnesol (FAR) its neurotoxic effects on brains adult mice. In study, two mouse models analgesia were used FAR at doses 50, 100, 200 mg/kg, injected intraperitoneally (i.p.). acetic acid–induced writhing test,...
It has been widely reported that the crude oil of Nigella sativa L., Ranunculaceae, seeds and its major chemical component thymoquinone present anticonvulsant activity. These facts led us to verify pharmacological potential five structurally related para-benzoquinones on pentylenotetrazol-induced seizures model, establish structural characteristics influence activity thymoquinone. The unsubstituted para-benzoquinone was compound exhibited highest potency, while 2-methyl-p-benzoquinone...
Perillyl alcohol (PA) is a natural compound found in essential oils. In this study, the antinociceptive activity of PA was evaluated using acetic acid and formalin tests. The involvement opioid system its mechanism action investigated. Potential histological changes hippocampus striatum were also assessed. induced writhing tests, mice pretreated with exhibited significant reductions writhing. inhibited injected paw licking response, naloxone partially reversed perillyl during test. And as...
The new coronavirus, SARS-CoV-2, which causes COVID-19 is easily transmitted from person to person. About 15% develop severe pneumonia and of these, 6% progress acute respiratory syndrome (SARS) multiple organ failure. Identify biomarkers that can predict individuals are likely be affected by disease at risk death crucial. However, the pathophysiology not completely elucidated characterization clinical profile people infected with SARS-CoV-2 remains unclear. Therefore, objective this study...
A hipovitaminose D é considerada uma epidemia mundial com implicações que podem afetar a saúde dos trabalhadores. Trata-se de um estudo transversal, realizado 91 trabalhadores, fim avaliar prevalência da e associações parâmetros metabólicos. Os participantes foram avaliados quanto ao perfil sociodemográfico ocupacional, exposição solar, antropometria pressão arterial. Foram realizados os exames: 25-hidroxivitamina [25(OH)D] demais Verificou-se 61,54% deficiência/insuficiência níveis séricos...