A5088868311- Pain Mechanisms and Treatments
- Essential Oils and Antimicrobial Activity
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Phytochemistry and Biological Activities
- COVID-19 Digital Contact Tracing
- Pharmacology and Obesity Treatment
- Youth, Drugs, and Violence
- Plant-based Medicinal Research
- Botulinum Toxin and Related Neurological Disorders
- COVID-19 and Mental Health
- Olfactory and Sensory Function Studies
- Pharmacological Receptor Mechanisms and Effects
- Sesquiterpenes and Asteraceae Studies
- Phytochemistry Medicinal Plant Applications
- Pharmacological Effects of Natural Compounds
- Phytochemistry and Bioactivity Studies
- Bioactive Compounds and Antitumor Agents
- Alkaloids: synthesis and pharmacology
- Natural Antidiabetic Agents Studies
- Veterinary Pharmacology and Anesthesia
- Pharmacogenetics and Drug Metabolism
- Neuropeptides and Animal Physiology
- SARS-CoV-2 detection and testing
- Tuberculosis Research and Epidemiology
Universidade Federal de Sergipe
2011-2024
Universidade Federal de Ouro Preto
2021
The Milton H. Erickson Foundation
2020
Universidade Federal do Piauí
2012
Abstract α‐Terpineol ( TPN ), a volatile monoterpene alcohol, is relatively non‐toxic and one of the major components essential oils various plant species. In this study, we tested for antihypernociceptive activity (25, 50 or 100 mg/kg, i.p.) in mice using mechanical models hypernociception induced by carrageenan CG , 300 μg/paw) involvement important mediators its cascade signalling, such as tumour necrosis factor‐α TNF ‐α, pg/paw), prostaglandin E 2 PGE ng/paw) dopamine DA 30 μg/paw). We...
We attempted to identify the antinociceptive and anti-inflammatory actions of monoterpene p-cymene. Firstly, behavioural screening was carried out verify influence p-cymene [25, 50, 100 mg/kg intraperitoneal (i.p.)] on central nervous system (CNS) activity. The activity evaluated by acetic acidinduced writhing response, formalin, hot-plate test, respectively. leukocyte migration induced injection carrageenan used assess p-Cymene showed depressant CNS after 4 h treatment also a possible...
<bold>Objective:</bold> To estimate the prevalence of SARS-CoV-2 antibodies in an asymptomatic population state Sergipe, Brazil. <bold>Methods:</bold> This cross-sectional study with stratified sampling (sex and age) includeD serological immunofluorescent tests for IgM IgG on samples from 3 046 individuals. Sample collection was performed wet-markets 10 most populous cities Exclusion criteria included symptomatic individuals health workers. The presence comorbidities registered....
Context: α-Terpineol (TPN) is a monoterpenoid alcohol present in the essential oils of several species Eucalyptus genus (Myrtaceae).
A doação de órgãos acarreta benefícios imensuráveis para o receptor, sendo, por vezes, a única alternativa determinadas enfermidades. O Brasil, sua vez, possui maior sistema público transplantes do mundo e vinha apresentando um incremento na taxa doadores até pandemia pela Covid-19. Contudo, é notório que país tem condições melhorar ainda mais os números realizados educação em saúde sobre tema, quando bem executada difundida, interfere positivamente no processo. partir disso objetivou-se...
O câncer de pele é a neoplasia mais comum no Brasil, apresenta como carcinógeno predominante radiação ultravioleta (UV), cujos danos são influenciados pela região geográfica, exposição solar, fotoproteção e fotótipo cutâneo. Os protetores solares tópicos produtos que possuem substâncias interferem na absorção cutânea da energia proveniente RUV. No entanto, segundo estimativa Sociedade Brasileira Dermatologia, cerca 63% das pessoas expõem ao sol sem qualquer forma proteção. A literatura...
The present study investigated the antinociceptive effects of Ocimum basilicum L. (Lamiaceae) leaf essential oil (LEO) and (-)-linalool (LIN) in formalin (2%)-, glutamate (25 µM)- capsaicin (2.5 µg)- induced orofacial nociception models mice. involvement these substances was further evaluated on neuronal excitability hippocampal dentate gyrus. Male mice (n=8/group) were pretreated separately with LEO by LIN (50, 100, 200 mg/kg, i.p.), morphine (5 i.p.) vehicle (saline + Tween 80 0.2%),...
This study investigated the possible antinociceptive effect of p-cymene in different tests orofacial nociception. The animals (mice) were pretreated (i.p.) with (25, 50, 100 mg/kg), morphine (5 or vehicle (0.2% Tween 80+saline), and then subsequently administered, subcutaneously into their upper lip: formalin, capsaicin, glutamate. nociceptive behavior response was characterized by time s that mice remained rubbing region, for a period 40 min formalin test (first phase, 0-6 min; second 21-40...
In this study, we describe the antinociceptive activity of ethanol extract (EE), chloroform (CF) and methanol (MF) fractions obtained from Sida cordifolia, popularly known in Brazil as “malva branca” or branca sedosa”. Leaves S. cordifolia were used to produce crude after CF MF. Experiments conducted on Swiss mice using glutamate formalin‐induced orofacial nociception. formalin test, all doses EE, MF significantly reduced nociception first (p < 0.001) second phase 0.001), which was also...
Hyptis pectinata L. Poit, known as ‘sambacaitá’, is used in Brazil to treat inflammatory and painful disorders. In this study, the antioxidant orofacial antinociceptive properties of aqueous extract H. leaves (AEPH) were assessed using vitro vivo models. Thus, AEPH reduced 2,2‐diphenyl‐1‐picrylhydrazyl radical up 72.10% with an EC 50 14.56 µg/ml. It also inhibited 40.80% lipoperoxidation induced by 2′‐azobis (2‐amidinopropane) dihydrochloride thiobarbituric acid‐reactive substances assay....
Citronellal is a monoterpene present in the oil of many species, including Cymbopogon winterianus Jowitt (Poaceae).The study investigated effect citronellal on inflammatory nociception induced by different stimuli and examined involvement NO-cGMP-ATP-sensitive K⁺ channel pathway.We used male Swiss mice (n = 6 per group) that were treated intraperitoneally with (25, 50 or 100 mg/kg) 0.5 h after subplantar injection 20 μl carrageenan (CG; 300 µg/paw), tumor necrosis factor-α (TNF-α; pg/paw),...
Carvacrol (CARV) is a phenolic monoterpene present in the essential oil of several aromatic spices. The purpose study was to evaluate antinociceptive effect CARV on formalin-, capsaicin-, and glutamate-induced orofacial nociception mice. Male mice were pretreated with [25, 50, 100 mg/kg body weight (BW), intraperitoneal (i.p.)], morphine (5 BW, i.p.), or vehicle (distilled water + one drop 0.3% cremophor distilled water), before formalin (20 μl, 2%), capsaicin 2.5 μg), glutamate (40 25 μM)...
This study aimed to evaluate the orofacial antinociceptive effect of Cymbopogon winterianus essential oil (LEO) complexed in β-cyclodextrin (LEO-CD) and assess possible involvement central nervous system (CNS). The LEO was extracted, chromatographed, β-cyclodextrin. complex characterized by differential scanning calorimetry (DSC) thermogravimetry derivative (TG/DTG). Male Swiss mice (2-3 months) were treated with LEO-CD (50-200 mg/kg, p.o.), vehicle (distilled water, or standard drug (i.p.)...
Abstract Background The exponential growth of COVID-19 cases in Brazil is overloading health systems with overcrowding hospitals and overflowing intensive care units. Increasing infection rates professionals can lead to the collapse system further worsen pandemic. aim this study was evaluate seroprevalence IgM IgG for SARS-CoV-2 workers Sergipe, Brazil. Methods targeted tests involved working on front line combat COVID-19. samples were collected month June, six hospital units state Sergipe....
O tabagismo é uma das principais causas de morte evitável no mundo, levando a 8 milhões óbitos anualmente e reduzindo expectativa vida dos fumantes em média 10 anos. Este estudo investigou relação entre o consumo tabaco uso outras substâncias psicoativas amostra 97 Lagarto, Sergipe. Utilizando um levantamento campo questionários estruturados, coletaram-se dados demográficos padrões como álcool, maconha cocaína, além do tabaco. Observou-se que 75% entrevistados consumiam cigarro...
This study aims to evaluate the impact of COVID-19 pandemic on number syphilis notifications (acquired, during pregnancy and congenital) in northeastern Brazil. An ecological was carried out using database provided by Ministry Health through Department Informatics SUS (DATASUS). The monthly numbers acquired, gestational congenital were organized Google Sheets online platform data statistically analyzed, Wilcoxon test, for (Jan/2020-Jun/2021) pre periods (Jan/2018-Dec/2019), with a...
O tabagismo é uma das principais causas evitáveis de morte e está associado ao desenvolvimento doenças graves, como câncer problemas cardiovasculares. Em 2019, mais 8 milhões pessoas morreram por ligadas uso do tabaco. Globalmente, cerca 22,3% da população adulta usa tabaco, enquanto no Brasil, estima-se que 25,6% dos adultos sejam fumantes. A relação entre saúde mental complexa recíproca, com estudos mostrando o tabaco pode tanto contribuir para quanto resultar transtornos mentais,...
O tabagismo é um problema global de saúde pública, associado a doenças físicas e à mental. Estudos indicam que fumantes possuem maior prevalência transtornos ansiedade, como Ansiedade Generalizada (TAG) Social (TAS), do não fumantes. No Brasil, reduziu, mas o impacto na mental persiste, especialmente entre mulheres, apresentam mais sintomas TAG. Este estudo, realizado com 97 adultos em Lagarto-SE, utilizou questionários estruturados para avaliar perfil sociodemográfico, grau envolvimento...
O presente artigo objetiva avaliar quais os fatores de caráter biopsicossociocultural e aspectos obstétricos assistenciais na saúde estão associados a prática desmame precoce do aleitamento materno fim auxiliar nas ações frente ao tema modo melhorar índices da amamentação. Trata-se uma revisão integrativa literatura, pesquisa descritiva, abordagem qualitativa método dedutivo realizada partir das bases dados eletrônicas PubMED, MEDLINE, LILACS, BVS, BDENF SciELO, usando descritores...
A tuberculose (TB) é uma doença infecciosa crônica, causada pelo Mycobacterium tuberculosis, sendo a que mais causa mortes no mundo. Um dos maiores obstáculos para seu combate, segundo Organização Mundial da Saúde (OMS), crescente prevalência de cepas resistentes à terapia medicamentosa padrão, culminando em refratariedade ao tratamento e maior mortalidade. O objetivo deste estudo foi realizar revisão integrativa literatura médica com o intuito identificar analisar impacto pobreza sobre...