A5064129942- Neuroendocrine regulation and behavior
- Renin-Angiotensin System Studies
- Hormonal Regulation and Hypertension
- Stress Responses and Cortisol
- Regulation of Appetite and Obesity
- Receptor Mechanisms and Signaling
- Neurotransmitter Receptor Influence on Behavior
- Electrolyte and hormonal disorders
- Adipose Tissue and Metabolism
- Animal Nutrition and Physiology
- Neuroscience of respiration and sleep
- Biochemical Analysis and Sensing Techniques
- Birth, Development, and Health
- Apelin-related biomedical research
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Thyroid Disorders and Treatments
- Heart Failure Treatment and Management
- Dietary Effects on Health
- Nutrition, Genetics, and Disease
- Hormonal and reproductive studies
- Attention Deficit Hyperactivity Disorder
- Cardiovascular Disease and Adiposity
- Diet and metabolism studies
- Sodium Intake and Health
- Diabetes and associated disorders
Universidade Federal Rural do Rio de Janeiro
2015-2024
Sociedade Brasileira de Cardiologia
2023
Universidade Federal do Rio de Janeiro
1994-2023
Universidade de São Paulo
1987-2014
Department of Physiological Sciences
2009
Faculdade de Medicina de São José do Rio Preto
2008
Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro
2005
Universidade Estadual Paulista (Unesp)
1996
Universidade de Ribeirão Preto
1990-1992
Montreal Clinical Research Institute
1992
Expansion of the blood volume causes a release atrial natriuretic peptide (ANP) that is believed to be important in induction subsequent natriuresis and diuresis which, turn, acts reduce increase volume. Since stimulation anteroventral portion third cerebral ventricle (AV3V) induced rapid elevation plasma ANP, whereas lesions AV3V were followed by marked decline concentration peptide, we hypothesized ANP from brain neuronal system might control ANP. The perikarya ANP-containing neurons are...
Our previous studies have shown that stimulation of the anteroventral third ventricle (AV3V) region brain increases atrial natriuretic peptide (ANP) release, whereas lesions AV3V or median eminence tuber cinereum block release ANP caused by blood volume expansion. These results suggest participation central nervous system is critical to this response. The role baroreceptors in response was evaluated current research studying plasma expansion induced intravenous injection hypertonic saline...
Estrogen receptors are located in important brain areas that integrate cardiovascular and hydroelectrolytic responses, including the subfornical organ (SFO) supraoptic (SON) paraventricular (PVN) nuclei. The aim of this study was to evaluate influence estradiol on neuroendocrine changes induced by hemorrhagic shock ovariectomized rats. Female Wistar rats (220–280 g) were treated for 7 days with vehicle or cypionate (EC, 10 40 μg/kg, sc). On 8th day, animals subjected hemorrhage (1.5 ml/100 g...
Results obtained in our laboratories have provided evidence for the participation of hypothalamic atrial natriuretic peptide (ANP) neuronal system regulation water and electrolyte homeostasis. The anterior ventral third ventricular (AV3V) region, a site perikarya ANP neurons, receives important afferent input from ascending serotoninergic axons. We hypothesized that tract might be involved control liberation ANP. Therefore, electrolytic lesions were produced mesencephalic dorsal raphé...
The present work was carried out to investigate the role of angiotensin II type 1 (AT ) receptors in nocturnal thirst and sodium appetite induced by classical models osmotic depletion challenges ovariectomized rats chronically treated with oil or oestradiol benzoate (EB, 20 μg per animal, s.c . daily). In both conditions, animals were given saline losartan (108 nmol i.c.v .), a selective AT receptor blocker. Oestrogen therapy significantly reduced water intake deprivation, produced frusemide...
Background: Thrombosis following stenosis of arteriovenous fistulae resulting in the loss vascular access for hemodialysis is an important complication patients with chronic renal failure.Percutaneous transluminal angioplasty being used more frequently treatment aiming at increasing patency fistulae.Objective: To evaluate primary percutaneous angioplasty.Patients and method: Patients submitted to Angiology service Hospital de Base 2004 were analyzed over average follow-up 10 months (2 16...
Few data are available on adolescent users because most behavioral studies anabolic-androgenic steroids (AAS) abuse have been performed in adults. Studies evaluating the impact of long-term effects AAS prepubertal phase even more uncommon. Accordingly, this study was developed to test hypothesis that changes induced by use during may be noted adult when treatment cycle is discontinued. Therefore, not only but also possible autonomic and electrolyte disorders were evaluated. For purpose, we...
Background/Aims: Furosemide is a loop diuretic widely used in clinical practice for the treatment of oedema and hypertension. The aim this study was to determine physiological molecular changes hypothalamic-neurohypophysial system as consequence furosemide-induced sodium depletion. Methods: Male rats were depleted by acute furosemide injection (10 30 mg/kg) followed access low diet distilled water 24 h. renal behavioural consequences evaluated, while blood brains collected evaluate...
We investigated the effects of chronic administration sertraline (SERT; ∼20 mg kg −1 day in drinking water), a selective serotonin reuptake inhibitor, on water and sodium intake plasma levels oxytocin (OT) vasopressin (AVP) basal stimulated conditions. Basal was reduced SERT‐treated rats. After 24 h deprivation, rats treated with SERT for 21 days ingested less than control (9.7 ± 0.5 versus 20.0 0.9 ml, respectively, at 300 min after presentation, P < 0.0001). Subcutaneous injection 2 m...
The present study determined the effect of an electrolytic lesion dorsal raphe nucleus (DRN) on water intake and sodium appetite. Male Wistar rats weighing 290-320 g with a DRN (L-DRN), performed two days before experiments confirmed by histology at end experiments, presented increased sensitivity to dehydration induced fluid deprivation. cumulative L-DRN reached 23.3 ± 1.9 ml (a 79% increase, N = 9) while sham-lesioned (SL-DRN) did not exceed 13.0 1.0 (N 11, P < 0.0001) after 5 h. treated...
The paraventricular nucleus (PVN) is involved in the control of sympathetic tone and secretion hormones, both functions known to be influenced by ghrelin, suggesting direct effect ghrelin this nucleus. However, effects on excitability different PVN neuronal populations have not been demonstrated. This study assessed activity neurons, correlating responses subpopulations neurons. We used a 64 multielectrode array examine administration extracellular spike frequency neurons recorded brain...
Objective. Considering the controversial data regarding role of brain renin-angiotensin system (RAS) on thirst and sodium appetite in ovariectomised rats, we aimed to evaluate angiotensin II (Ang II) AT1-receptor nocturnal fluids intake. Materials methods. Groups Wistar female rats were chronically given oestrogen or vehicle its influence effects induced by i.c.v. injection losartan,Ang I Ang II. Results. The losartan decreased basal water intake group.Ang but not I-induced dipsogenic...
The present study aimed to investigate the role of angiotensin II (Ang II) on sodium appetite in rats subjected a normal or low-sodium diet (1% > 0.1% NaCl) for 4 days. During restriction, reduction water intake, urinary volume and excretion was observed. After diet, we observed decreased plasma protein concentrations haematocrit associated with slight arterial pressure, without any significant changes heart rate, natraemia, corticotrophin-releasing hormone mRNA expression paraventricular...