A5071635681- Hormonal and reproductive studies
- Ion channel regulation and function
- Adipose Tissue and Metabolism
- Hormonal Regulation and Hypertension
- Cardiac Ischemia and Reperfusion
- Renin-Angiotensin System Studies
- Heart Rate Variability and Autonomic Control
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Cardiovascular Disease and Adiposity
- Cardiac electrophysiology and arrhythmias
- Stress Responses and Cortisol
- Thyroid Disorders and Treatments
- Pulmonary Hypertension Research and Treatments
- Cardiac Fibrosis and Remodeling
- Telomeres, Telomerase, and Senescence
- Pharmacological Effects and Assays
- Birth, Development, and Health
- Selenium in Biological Systems
- Cardiovascular Function and Risk Factors
- Nitric Oxide and Endothelin Effects
- Cardiac Imaging and Diagnostics
- Receptor Mechanisms and Signaling
- Blood Pressure and Hypertension Studies
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Heavy Metal Exposure and Toxicity
Universidade Federal do Rio de Janeiro
2017-2025
Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro
2018-2025
Universidade Federal Rural do Rio de Janeiro
2014-2023
Sociedade Brasileira de Cardiologia
2023
University of Iowa
2018-2020
ABSTRACT Cardiovascular diseases (CVDs) are the leading cause of death globally. Decrease in female sex hormones during menopause increases risk cardiovascular disease, mainly ischemic heart disease (IHD). Quercetin, a flavonoid, has beneficial properties CVDs due to its antioxidant, anti‐inflammatory, and anti‐apoptotic effects. The aim this study was investigate effects quercetin on susceptibility cardiac reperfusion arrhythmias mitochondrial function ovariectomized rats (OVX)....
Aim Thyroid dysfunctions can increase the risk of myocardial ischemia and infarction. However, repercussions on cardiac ischemia/reperfusion (IR) injury remain unclear so far. We report here effects hypothyroidism thyrotoxicosis in susceptibility to IR isolated rat hearts compared euthyroid condition potential role antioxidant enzymes. Methods Hypothyroidism were induced by administration methimazole (MMZ, 300 mg/L) thyroxine (T4, 12 mg/L), respectively drinking water for 35 days. Isolated...
Activation of central AT1Rs (angiotensin type 1 receptors) is required for the increased blood pressure, polydipsia, and salt intake in deoxycorticosterone acetate (DOCA)-salt hypertension. TRV120027 (TRV027) an AT1R-biased agonist that selectively acts through β-arrestin. We hypothesized intracerebroventricular administration TRV027 would ameliorate effects DOCA-salt. In a neuronal cell line, induced AT1aR internalization dynamin clathrin-mediated endocytosis. next evaluated effect chronic...
Introduction: After the spread of new coronavirus (COVID-19) around world, some sanitary measures were adopted to reduce transmission rate. Social distancing and use masks are one them. Therefore, after months pandemic situation, levels infection mortality began decline in regions Brazil. As a result, states municipalities started relax their quarantines allowing access community places like gyms. To these is obligatory masks. However, there lack knowledge about efficiency closed...
Considering the recognized role of thyroid hormones on cardiovascular system during health and disease, we hypothesized that type 2 deiodinase (D2) activity, main activation pathway thyroxine (T4)-to-triiodothyronine (T3), could be an important site to modulate hormone status, which would then constitute a possible target for β-adrenergic blocking agents in myocardial infarction (MI) model induced by left coronary occlusion rats. Despite sustained dramatic fall serum T4 concentrations...
Hypothyroidism is the result of inadequate production thyroid hormone or action in target tissues. can be seen secondary to hyperadrenocorticism with an overlapping clinical signs. We intend demonstrate that symptoms hypothyroidism undetectable even if there already evidence hormonal disease. Male Wistar rats (~ 280g, n = 7) were submitted daily subcutaneous administration 200µg adrenocorticotropic (0.2ml ACTH 1‐24 synthetic 1mg/ml) vehicle (NaCl 0,9% 0.2ml) for 7 days. At end experiment,...
The objective of this study was to evaluate the possible occurrence behavioral changes in offspring female rats supplemented during pregnancy and lactation with sodium selenite. Two groups were treated with: saline or selenite at a dose 1 mg/kg through oral route. Thyroid status determined by serum analysis thyroid hormones for gene expression analyzes, we used RT‐qPCR. At 60 days‐old, underwent assessment an open field test, elevated plus maze object recognition task swimming forced test...
This study aimed to elucidate, for the first time, effects of chronical oral treatment with zinc chloride on depressant‐like behavior Wistar rats and correlate them neuroendocrine profile promoted by our protocol. Two groups male (200‐250 g) were treated (15 mg/kg n=16) or isotonic saline (n=17) during 30 days. The kept in a controlled room temperature light/dark cycle food ad libitum. After treatment, both submitted behavioral assessment an open field (OF), elevated plus maze (EPM) forced...