A5083443570- Thyroid Disorders and Treatments
- Growth Hormone and Insulin-like Growth Factors
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Cardiovascular Disease and Adiposity
- Thyroid Cancer Diagnosis and Treatment
- Adipose Tissue and Metabolism
- Biochemical effects in animals
- Neurogenesis and neuroplasticity mechanisms
- Neuroscience and Neuropharmacology Research
- Ion channel regulation and function
- Stress Responses and Cortisol
- Estrogen and related hormone effects
- Hypothalamic control of reproductive hormones
- Vitamin D Research Studies
- Neuroscience of respiration and sleep
- Cholinesterase and Neurodegenerative Diseases
- Retinoids in leukemia and cellular processes
- Protein Kinase Regulation and GTPase Signaling
- S100 Proteins and Annexins
- Heart Rate Variability and Autonomic Control
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- High Altitude and Hypoxia
- Hormonal and reproductive studies
- Muscle metabolism and nutrition
- Cardiac Imaging and Diagnostics
Universidade Federal Rural do Rio de Janeiro
2011-2024
Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro
2007-2012
Universidade Federal do Rio de Janeiro
2005-2011
Centro Universitário da Cidade
2008
Instituto de Biofísica Carlos Chagas Filho
2007
In humans, there is a significant decrease in serum T(3) and increase rT(3) at different time points after myocardial infarction, whereas TSH T(4) remain unaltered. We report here course study of pituitary-thyroid function thyroid hormone metabolism rats subjected to infarction by left coronary ligation (INF). INF- sham-operated animals were followed serial deiodination assays tests, just before, 1, 4, 8, 12 wk surgery. At 4 INF, liver type 1 deiodinase activity was significantly lower,...
The hypothalamic–pituitary–thyroid axis is affected by acute exercise, but the mechanisms underlying thyroid function changes after exercise remain to be defined. aim of this study was elucidate effects a session on treadmill at 75% maximum oxygen consumption rats. Male Wistar rats were divided into five groups: control (without exercise), and killed immediately (0 min) or 30, 60, 120 min end session. A significant increase in serum tri-iodothyronine (T 3 ) occurred with gradual decrease...
Adult hypothyroidism is a highly prevalent condition that impairs processes, such as learning and memory. Even though tetra-iodothyronine (T(4)) treatment can overcome the in majority of cases, it cannot fully recover patient's capacity In this work, we analyzed cellular molecular changes adult brain occurring with development experimental hypothyroidism.Adult male Sprague-Dawley rats were treated 6-propyl-2-thiouracil (PTU) for 20 days to induce hypothyroidism. Neuronal astrocyte apoptosis...
What is the central question of this study? The relationship between thyroid system and sleep deprivation has seldom been assessed in literature, mounting evidence exists that disturbances influence human lifestyles. aim study was to investigate hypothalamic-pituitary-thyroid axis hormone metabolism sleep-deprived sleep-restricted rats. main finding its importance? Central hypothyroidism high thyroxine (T4 ) 3,5,3'-triiodothyronine (T3 activation brown adipose tissue were observed following...
Iodothyronine deiodinase activities are regulated by sex steroids; however, the mechanisms underlying reported sexual dimorphism poorly defined. In present report, we aimed to investigate whether type 1 (D1) exists early in development studying pre-pubertal male (Pm) and female (Pf) rats, as well adult controls (C) gonadectomized females rats. Adult Wistar rats were studied 21 days after orchiectomy (Tex), ovariectomy (Ovx), estradiol benzoate (Eb) replacement. Serum total triiodothyronine...
Purpose: The administration of anabolic-androgenic steroids (AAS) to improve athletic performance has increased notably during the past three decades, even among nonathletes. Thyroid function is affected by AAS use in humans, although mechanisms effects are unclear. We evaluated on thyroid supraphysiologic doses nandrolone decanoate (DECA), which one most used. Methods: Male Wistar rats were treated with vehicle or 1 mg·100 g−1 body weight (b.w.) DECA, once a week for 8 wk, intramuscularly....
Aim Thyroid dysfunctions can increase the risk of myocardial ischemia and infarction. However, repercussions on cardiac ischemia/reperfusion (IR) injury remain unclear so far. We report here effects hypothyroidism thyrotoxicosis in susceptibility to IR isolated rat hearts compared euthyroid condition potential role antioxidant enzymes. Methods Hypothyroidism were induced by administration methimazole (MMZ, 300 mg/L) thyroxine (T4, 12 mg/L), respectively drinking water for 35 days. Isolated...
During food restriction, decreased basal metabolic rate secondary to reduced serum thyroid hormones levels contributes weight loss resistance. Thyroxine (T 4 ) and 3,3′,5-tri-iodothyronine 3 administration during caloric restriction produce deleterious side effects; however, the of physiological doses T has never been evaluated. The aim this study was analyze effects low replacement in Wistar rats subjected 40% restriction. Food for 30 days led significantly liver type 1 deiodinase activity,...
The sodium–iodide symporter (NIS) mediates iodide uptake into the thyrocytes, which is important for diagnosis and therapy of thyroid disorders. Decreased ability to in carcinomas reduces efficacy radioiodine therapy, retinoic acid (RA) treatment reinduces uptake. effectiveness depends not only on but also thyrocytes organify iodine, catalyzed by thyroperoxidase (TPO) presence H 2 O . Our goal was determine influence RA uptake, iodine organification, TPO dual oxidase (DuOx) activities....
Retinoic acid is widely used in dermatological treatment and thyroid cancer management; however its possible side-effects on normal function remains unknown. We aimed to determine the effects of retinoic adult female rats.Female Wistar rats were treated with all-trans-retinoic 13-cis for 14 28 days. Then, killed was evaluated.Serum T4 thyrotropin levels remained unchanged, while serum T3 increased animals No changes observed hepatic or renal type 1 iodothyronine deiodinase (D1) activities,...
The objective of this study was to identify thyroid hormones and examine their putative site synthesis in Achatina fulica snails. For purpose, radioimmunoassays were performed for T3 T4 before after long starvation with or without hemolymph deproteinization. Sodium/iodide symporter activity vivo analyzed through 125I administration KClO4 pretreatment. Only detected, its concentration decreased due However, high-performance liquid chromatography analysis also showed the presence T2 apart from...
We investigated the morphologic and functional changes of infarcted rat hearts under a paradigm angiotensinconverting enzyme inhibition. Myocardial infarction was induced by left coronary artery ligation control group (SHAM) underwent sham-operation. Infarcted rats received normal drinking water with (CAP group) or without (INF captopril. Functional assessment performed electro (ECG) echocardiogram (ECHO) just before 21 days after surgery. The ECG INF CAP showed similar values resembled...
Based on the relevance of renin-angiotensin system and ongoing controversy regarding role sympathetic nervous in thyroid hormone-induced cardiac hypertrophy, aim present study was to establish whether putative difference degree hypertrophy exhibited by males females might be related differences sympathetic-vagal balance and/or mice different genders. Male female (n = 117) were given 0.1 mg kg(-1) triiodothyronine or normal saline each day for 10 days consecutively. At end that period, heart...
Introduction: Isometric strength training (IST) is an important component of different types sport and others activities daily life. However, until the present moment, no studies have linked isometric with acetylcholinesterase (AChE) activity changes. Objective: We evaluated effects IST on muscular AChE strength. Materials Methods: Wistar rats (n =20) were divided into 2 groups: Control group (Ctr) (sedentary) trained (Tr) (submitted to 8 weeks training). The muscle in solear (SOL) Extensor...
Considering the recognized role of thyroid hormones on cardiovascular system during health and disease, we hypothesized that type 2 deiodinase (D2) activity, main activation pathway thyroxine (T4)-to-triiodothyronine (T3), could be an important site to modulate hormone status, which would then constitute a possible target for β-adrenergic blocking agents in myocardial infarction (MI) model induced by left coronary occlusion rats. Despite sustained dramatic fall serum T4 concentrations...
Background: Adult hypothyroidism is a highly prevalent condition that impairs processes, such as learning and memory. Even though T4 treatment can overcome the in majority of cases, it cannot fully recover patient’s capacity In this work we analyzed cellular molecular changes adult brain occurring with development experimental hypothyroidism. Methods: male Sprague-Dawley rats were treated 6Propyl-2-thiouracil (PTU) for 20 days to induce Neuronal astrocyte apoptosis hippocampus control...
Abstract Considering the recognized role of thyroid hormones on cardiovascular system during health and disease, we hypothesized that type 2 deiodinase (D2) activity, main activation pathway thyroxine (T4)-to-triiodothyronine (T3), could be an important site to modulate hormone status, which would then constitute a possible target for β-adrenergic blocking agents in myocardial infarction (MI) model induced by left coronary occlusion rats. Despite sustained dramatic fall serum T4...