A5102003109- Thyroid Disorders and Treatments
- Stress Responses and Cortisol
- Regulation of Appetite and Obesity
- Adipose Tissue and Metabolism
- Exercise and Physiological Responses
- Adipokines, Inflammation, and Metabolic Diseases
- Birth, Development, and Health
- Thyroid Cancer Diagnosis and Treatment
- Vitamin D Research Studies
- Cancer-related Molecular Pathways
- Biochemical Analysis and Sensing Techniques
- Pancreatic function and diabetes
- interferon and immune responses
- Liver Disease Diagnosis and Treatment
- Protein Kinase Regulation and GTPase Signaling
- Human Health and Disease
- Mercury impact and mitigation studies
- Trace Elements in Health
- Muscle metabolism and nutrition
- Estrogen and related hormone effects
- Apelin-related biomedical research
- Neuroendocrine regulation and behavior
- Cytokine Signaling Pathways and Interactions
- Hypothalamic control of reproductive hormones
- Neuroscience and Neuropharmacology Research
Universidade Federal do Rio de Janeiro
1996-2019
Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro
2007-2017
Instituto de Biofísica Carlos Chagas Filho
2007-2014
Stazione Zoologica Anton Dohrn
2004
Activating mutations in RAS protooncogenes are associated with several different histotypes of thyroid cancer, including anaplastic carcinoma. The latter is the most aggressive cancer gland, showing little or no expression differentiated phenotype. Likewise, viral oncogenes FRTL-5 rat cells mimics such loss differentiation. We established cell lines stably expressing constitutively active forms RAS, either (v-Ha-RAS v-Ki-RAS) cellular (H-RASV12) origin and generated a tamoxifen-inducible...
Iodothyronine deiodinase activities are regulated by sex steroids; however, the mechanisms underlying reported sexual dimorphism poorly defined. In present report, we aimed to investigate whether type 1 (D1) exists early in development studying pre-pubertal male (Pm) and female (Pf) rats, as well adult controls (C) gonadectomized females rats. Adult Wistar rats were studied 21 days after orchiectomy (Tex), ovariectomy (Ovx), estradiol benzoate (Eb) replacement. Serum total triiodothyronine...
Adequate maternal iodine consumption during pregnancy and lactation guarantees normal thyroid hormones (TH) production, which is crucial to the development of fetus. Indeed, deficiency clearly related hypothyroidism deleterious effects in fetal development. Conversely, excess (IE) on function are still controversial. Therefore, this study aimed investigate impact IE exposure periods hypothalamus-pituitary-thyroid axis. IE-exposed dams presented reduced serum TH concentration increased...
Abstract This study aimed to investigate the consequences of maternal exposure iodine excess (IE; 0.6 mg NaI/L) throughout pregnancy and lactation on hypothalamus-pituitary-thyroid axis male offspring in adulthood. Maternal IE increased hypothalamic Trh mRNA expression pituitary Tsh secretion adult offspring. Moreover, IE-exposed rats presented reduced thyroid hormones levels, morphological alterations follicles, oxidative stress decreased differentiation markers (Tshr, Nis, Tg, Tpo, Mct8)...
What is the central question of this study? Does glucocorticoid excess disrupt brown adipose tissue (BAT) phenotype and function? main finding its importance? Glucocorticoid induced an extensive remodelling interscapular BAT, resulting in a white-like association with metabolic disturbances. Glucocorticoids might be important modulator BAT physiology may have role pathophysiology disturbances by excess.In mammals, centrally involved energy metabolism. To test hypothesis that disrupts...
Mercury seems to exert an inhibitory effect on deiodinases, but there are few studies using Thimerosal (TM) as the mercury source. We aimed elucidate of TM thyroid hormones peripheral metabolism. Adult Wistar female rats received 0.25 µg or 250 TM/100 g BW, IM, twice a week, for month. evaluated serum total T3 and T4, D1 activity 125I-rT3 tracer, D2 125I-T4 NADPH oxidase was measured by Amplex-red/HRP method mRNA levels real time PCR. Serum T4 increased decreased greatest dose TM. Even...