A5102165790- Dementia and Cognitive Impairment Research
- Heart Failure Treatment and Management
- Drug Transport and Resistance Mechanisms
- Intensive Care Unit Cognitive Disorders
- Endometriosis Research and Treatment
- Cardiac Health and Mental Health
- NF-κB Signaling Pathways
- Cardiomyopathy and Myosin Studies
- Protein Kinase Regulation and GTPase Signaling
- Image Processing and 3D Reconstruction
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pleistocene-Era Hominins and Archaeology
- Thyroid Cancer Diagnosis and Treatment
- Blood Pressure and Hypertension Studies
- Amyotrophic Lateral Sclerosis Research
- interferon and immune responses
- Metabolism, Diabetes, and Cancer
- Immune Response and Inflammation
- Alzheimer's disease research and treatments
- Cancer-related Molecular Pathways
- Heat shock proteins research
- Pharmaceutical Practices and Patient Outcomes
- Muscle Physiology and Disorders
- Advanced MRI Techniques and Applications
- EEG and Brain-Computer Interfaces
Technical University of Munich
2024-2025
Friedrich-Alexander-Universität Erlangen-Nürnberg
2023
Universität Ulm
2017
Max Delbrück Center
2014-2015
Charité - Universitätsmedizin Berlin
2010-2014
University of California, San Francisco
2011
University of Nebraska Medical Center
2009-2010
Ceinge Biotecnologie Avanzate (Italy)
2005
Stazione Zoologica Anton Dohrn
2004
University of Würzburg
2002
Activating mutations in RAS protooncogenes are associated with several different histotypes of thyroid cancer, including anaplastic carcinoma. The latter is the most aggressive cancer gland, showing little or no expression differentiated phenotype. Likewise, viral oncogenes FRTL-5 rat cells mimics such loss differentiation. We established cell lines stably expressing constitutively active forms RAS, either (v-Ha-RAS v-Ki-RAS) cellular (H-RASV12) origin and generated a tamoxifen-inducible...
A decrease in the supply of ATP from creatine kinase (CK) system is thought to contribute evolution heart failure. However, previous studies on mice with a combined knockout mitochondrial and cytosolic CK (CK(-/-)) have not revealed overt left ventricular dysfunction. The aim this study was employ novel MRI techniques measure maximal myocardial velocity (V(max)) perfusion thus determine whether abnormalities phenotype existed CK(-/-) mice, both at baseline 4 wk after infarction (MI). As...
BackgroundCognitive impairment is a recognized consequence of heart failure; however, there are no neuropsychological batteries with documented psychometric data in the chronic failure population.
Southern Bavaria marks a marginal area of the earliest Linear Pottery Culture in Central Europe. It is adjacent to Alpine Foreland, which represents an for potential interaction with other cultural entities. Neolithic research this region has largely focused on pottery analysis as basis answering chrono-cultural questions, leaving lithic proxy spatial processes at lower resolution. For comparisons preceding Mesolithic however, study finds essential they are common denominator between two...
Objective: Radiotherapy administered to control thoracic cancers results in a partial irradiation of the heart at mean doses up 19 Gy, which increases risk developing spectrum cardiovascular diseases known as radiation-induced disease (RIHD). As inflammation is major driver development RIHD, we investigated potential anti-inflammatory agent cannabidiol (CBD) attenuate irradiation-induced damage vivo. Methods: Female C57BL/6 mice were given daily injections CBD (i.p., 20 mg/kg body weight)...
Multidrug resistance (MDR) is a major cause for cancer chemotherapy failure. Among the numerous strategies to overcome persistent action of proinflammatory cytokines, such as tumor necrosis factor α (TNF-α) permits downregulation MDR-associated genes, including ATP-binding cassette, subfamily B 1 gene (ABCB1). A key regulator ABCB1 expression transcription nuclear κ light chain enhancer (NF-κB)/p65. We analyzed diverging short- and long-term effects TNF-α regarding modulation NF-κB/p65...
Radiotherapy, which is commonly used for the local control of thoracic cancers, also induces chronic inflammatory responses in microvasculature surrounding normal tissues such as lung and heart that contribute to fatal radiation-induced diseases (RILDs) pneumonitis fibrosis. In this study, we investigated potential cannabidiol (CBD) attenuate irradiation damage vasculature.
Stress-inducible heat shock protein 70 (Hsp70), which functions as a molecular chaperone and is frequently overexpressed in different cancer cell types, present on the surface of tumor cells actively released into circulation free extracellular lipid vesicle-associated forms. Since exact pathomechanism endometriosis has not yet been elucidated (although it associated with development endometrial ovarian cancer), we asked whether Hsp70 circulating endometriotic (CECs) reflect presence...
Objective: Reliable assessment of cognitive functions is a challenging task in amyotrophic lateral sclerosis (ALS) patients unable to speak and write. We therefore present an eye-tracking based neuropsychological screening tool on the Edinburgh Cognitive Behavioural ALS Screen (ECAS), standard for deficits ALS. Methods: In total, 46 50 healthy controls matched age, gender education were tested with oculomotor paper-and-pencil version ECAS. Results: Significant correlation between both...
Abstract Identifying, analyzing, and explaining trends in the development of material culture is one major concerns prehistoric archaeology. The traditional recording data typologies, however, not optimal for answering question diachronic change because typological capture variability poorly are often incompatible with multivariate statistics. To overcome these problems, we present PyREnArA (Python-R-Environment Artifact Analysis), a trait-based tool that allows systematic diversity way...
The stress-inducible heat shock protein 70 (Hsp70), which functions as a molecular chaperone and is frequently overexpressed in different cancer cell types, presented on the surface of tumor cells actively released into circulation free extracellular lipid vesicle-associated forms. Since exact pathomechanism endometriosis has not yet been elucidated but associated with development endometrial ovarian cancer, we asked whether Hsp70 circulating endometriotic (CECs) reflects presence...
Abstract Multidrug resistance (MDR) still represents one major obstacle for cancer chemotherapy. The ABC transporter ABCB1/PgP is an important factor mediating of tumor cells towards cytostatic drug treatment. Among numerous overcoming strategies, persistent treatment pro-inflammatory cytokines, such as necrosis factor-alpha (TNF-alpha) leads to down-regulation MDR-associated genes, ABCB1. transcription NF-κB/p65 a known key regulator ABCB1 expression. We analyzed short- and long-term...
Abstract Multidrug resistance (MDR) is one major cause for cancer chemotherapy failure. Therefore, numerous overcoming strategies have been tested tumor chemosensitization. Among these, persistent action of proinflammatory cytokines, such as necrosis factor-alpha (TNF) showed great potential downregulation MDR-associated genes, particularly the ABC-transporter P-glycoprotein Pgp, encoded by mdr1 gene. These cytokine-mediated effects are still under controversial discussion, since transient...