A5000542876- Immune Response and Inflammation
- Natural product bioactivities and synthesis
- Ion channel regulation and function
- Pain Mechanisms and Treatments
- Receptor Mechanisms and Signaling
- Neuroendocrine regulation and behavior
- Phytochemistry and Biological Activities
- Stress Responses and Cortisol
- Tryptophan and brain disorders
- Neuropeptides and Animal Physiology
- Neuroscience and Neuropharmacology Research
- Pharmacological Effects of Natural Compounds
- Vagus Nerve Stimulation Research
- Herbal Medicine Research Studies
- Sphingolipid Metabolism and Signaling
- Analytical Chemistry and Chromatography
- Neuroscience of respiration and sleep
- Mosquito-borne diseases and control
- Immune Cell Function and Interaction
- Inflammasome and immune disorders
- Infectious Encephalopathies and Encephalitis
- Phytochemistry and biological activity of medicinal plants
- Venomous Animal Envenomation and Studies
- Computational Drug Discovery Methods
- Analytical Methods in Pharmaceuticals
Universidade Federal Rural do Rio de Janeiro
2011-2023
Universidade de São Paulo
2008-2014
Universidade de Ribeirão Preto
2008-2014
WiLAN (Canada)
2013
SUPERA Park of Innovation and Technology of Ribeirão Preto
2009-2013
Universidade do Estado do Rio de Janeiro
2009
To identify the compounds responsible for antinociceptive and anti-inflammatory effects previously described Sedum dendroideum, through bioassay-guided fractionation procedures.Antinociceptive activity was evaluated mouse acetic acid-induced writhing model. The assessed croton oil-induced ear oedema carrageenan-induced peritonitis.The dendroideum juice afforded seven known flavonoids identified with basis on NMR data. oral administration of major kaempferol glycosides kaempferitrin [1]...
Kalanchoe pinnata (KP) is popularly used for treating inflammatory diseases. This study investigated the antinociceptive, antiedematogenic, and anti‐inflammatory potential of subcutaneous administration KP flower aqueous extract (KPFE), its ethyl acetate (EtOAcF) butanol (BuOHF) fractions, main flavonoid [quercetin 3‐ O ‐ α ‐L‐arabinopyranosyl (1 → 2) ‐L‐rhamnopyranoside] (KPFV) in mice, as well possible mechanisms action. KPFE (30–300 mg/kg) KPFV (1–10 inhibited acetic acid‐induced writhing...
The present study investigated the febrile response in zymosan-induced arthritis, as well increase PGE(2) concentration cerebrospinal fluid (CSF), along with effects of antipyretic drugs on these responses rats. Zymosan intra-articularly injected at dose 0.5 mg did not affect body core temperature (Tc) compared saline (control), whereas doses 1 and 2 mg, zymosan promoted a flattened Tc declined thereafter. 4 was selected for further experiments because it elicited marked long-lasting...
BACKGROUND AND PURPOSE Bacterial lipopolysaccharide (LPS) induces fever through two parallel pathways; one, prostaglandin (PG)‐dependent and the other, PG‐independent involving endothelin‐1 (ET‐1). For a better understanding of mechanisms by which dipyrone exerts antipyresis, we have investigated its effects on changes in PGE 2 content plasma, CSF hypothalamus induced either LPS or ET‐1. EXPERIMENTAL APPROACH Rats were given (i.p.) (120 mg·kg −1 ) indomethacin (2 30 min before injection (5...
The antipyretic and hypothermic prodrug dipyrone prevents PGE2 -dependent -independent fever induced by LPS from Escherichia coli Tityus serrulatus venom (Tsv) respectively. We aimed to identify the metabolites responsible for effects.Male Wistar rats were treated i.p. with indomethacin (2 mg·kg(-1) ), dipyrone, 4-methylaminoantipyrine (4-MAA), 4-aminoantipyrine (4-AA) (60-360 4-formylaminoantipyrine, 4-acethylaminoantipyrine (120-360 ) or vehicle 30 min before injection of (50 μg·kg(-1) Tsv...
Cecropia Loefl. species (Urticaceae) are widely spread across the rainforest in tropical and subtropical regions of Central South America. Inhabitants different Brazil employ leaves, fruits sprouts hololeuca Miq. mainly as anti-inflammatory, anti-asthmatic, expectorant, fever suppressant, against cough. To evaluate antinociceptive anti-inflammatory activities an aqueous leaf extract C. a murine model zymosan-induced arthritis (ZIA) characterize compounds contributing to these effects. The...
The stem bark of Anacardium occidentale L. (Anacardiaceae), commonly called cashew, is used in Brazilian traditional medicine for the treatment gastric and inflammatory disorders. present study was carried out to investigate vivo anti-inflammatory activities acetone extract (AE) A. occidentale. We evaluated pharmacological this plant material through analgesic, antiedematogenic chemotaxic inhibitory effects produced by AE. oral administration (p.o.) mice with AE (0.1, 0.3 1.0 g/kg) or...
Abstract Cerebral malaria pathogenesis involves vascular dysfunction with low nitric oxide (NO) bioavailability, vasoconstriction and impaired vasodilation, leading to ischemia, tissue hypoxia ultimately death. blood flow (CBF) NO other pathways, including arachidonic acid (AA)-derived metabolites. Here we show that mice experimental cerebral (ECM) by P. berghei ANKA showed marked decreases in CBF (as assessed laser speckle contrast imaging - LSCI) administration of L-arginine...
The impairment in arginine vasopressin (AVP) secretion during sepsis is described clinical and experimental studies has been associated with oxidative stress, apoptosis, diminished activation of hypothalamic neurons. Few have, however, assessed these abnormalities survivors. Here we performed two sets experiments on Wistar rats that had subjected to by cecal ligation puncture (CLP) or nonmanipulated (naive) as control. In the first set, tissues blood were collected from survivor 10 days...
After oral administration dipyrone is rapidly hydrolyzed to 4-methylaminoantipyrine, which absorbed and further metabolized 4-formylaminoantipyrine 4-aminoantipyrine, acetylated by a polymorphic N-acetyltransferase system 4-acetylaminoantipyrine. To evaluate the presence of metabolites in different rat matrices after intraperitoneal administration, an analytical method was developed validated.The four main were extracted from plasma, cerebrospinal fluid hypothalamus samples LLE prior...
Fever is considered an important component of the acute phase response body in defence against invading organisms such as bacteria. Quercetin, representative flavonoid class, has been extensively studied anti-inflammatory agent. In present study, we investigated effect quercetin, administered orally (5, 25 and 50 mg kg(-1)) or intraperitoneally (50 kg(-1)), on febrile induced by either mug intravenously (5 injected lipopolysaccharide (LPS from Escherichia coli) rats. contrast with well known...
Mikania lindleyana DC., Asteraceae (sucuriju), grows in the Amazon region, where is frequently used to treat pain, inflammatory diseases and scarring. This study was carried out investigate phytochemical profile accompanied by vivo antinociceptive anti-inflammatory screening of n-hexane (HE), dichloromethane (DME) methanol (ME) extracts obtained from aerial parts plant. The oral administration ME (0.1, 0.3, 1 g/kg) caused a dose-related reduction (16.2, 42.1 e 70.2%) acetic acid-induced...
This study investigated the involvement of prostaglandins and regulated on activation, normal T cell expressed secreted (RANTES), in fever induced by live Staphylococcus aureus (no. 25923, American Type Culture Collection) injection rats. S. was injected intraperitoneally at 10(9), 10(10), 2 × 10(10) colony-forming units (CFU)/cavity, body temperature (T(b)) measured radiotelemetry. The lowest dose a modest transient increase T(b), whereas two higher doses promoted similar long-lasting...