A5050896988- Phytochemistry Medicinal Plant Applications
- Essential Oils and Antimicrobial Activity
- Bioactive Natural Diterpenoids Research
- Plant biochemistry and biosynthesis
- Agricultural and Food Sciences
- Ginkgo biloba and Cashew Applications
- Computational Drug Discovery Methods
- Wastewater Treatment and Reuse
- Biodiesel Production and Applications
- Phytochemicals and Medicinal Plants
- Natural Antidiabetic Agents Studies
- Water Quality and Pollution Assessment
- Traditional and Medicinal Uses of Annonaceae
- Insect Pest Control Strategies
- Natural product bioactivities and synthesis
- Analytical Methods in Pharmaceuticals
- Synthesis and properties of polymers
- Plant tissue culture and regeneration
- Biological Activity of Diterpenoids and Biflavonoids
- Rural Development and Agriculture
- Antioxidant Activity and Oxidative Stress
- Sphingolipid Metabolism and Signaling
- Synthesis and biological activity
- Periodontal Regeneration and Treatments
- Ethnobotanical and Medicinal Plants Studies
Universidade Federal do Rio Grande do Norte
2008-2023
Universidade Potiguar
2013-2023
Laureate Education
2013-2021
University of Rio Grande and Rio Grande Community College
2009
Universidade Federal do Rio de Janeiro
1996-2006
Universidade Federal Rural do Rio de Janeiro
1998
MULTIDISCIPLINARY SCIENTIFIC STUDIES.This paper presents a program emphasizing ethnopharmacological approaches that could allow great success in the study of medicinal plants.The minimum research team should consist botanist, chemist and pharmacologist with each carrying responsibility for answering sequential fashion critical questions.The chemical composition pharmacological properties very efficient plant Croton cajucara were investigated according to approaches.The this proved be both...
MEDICINAL PLANTS: SAFE CURE?This paper reviews the recent literature on synergism, adulteration and risks of using medicinal plants.The use copaiba sacaca plants as well their side effects, are also described.In addition, new regulations phytotherapeutic registration in Brazil Europe discussed.
The anti-inflammatory and antinociceptive effects of trans-dehydrocrotonin, isolated from the bark Croton cajucara (Euphorbiaceae), were investigated using several animal models. trans-dehydrocrotonin produced a significant inhibition carrageenin-induced paw edema cotton pellet granuloma in rats. It also inhibited writhings mice induced by acetic acid, but did not show effect hot-plate test mice. LD50 t-DCTN was 555.0 mg/kg (p.o.) for
The 19-nor-clerodane trans-crotonin (CTN) and the triterpene acetyl aleuritolic acid (AAA), isolated from stem bark of Croton cajucara Benth (Euphorbiaceae), a traditional medicinal plant Amazon region Brazil, as well aqueous extract (AE) its bark, were submitted to pharmacological screening for anti-inflammatory antinociceptive activities in animal models. oral administration AAA (50 mg/kg), CTN mg/kg) or AE (300 inhibited acetic acid-induced writhing mice. AE, had shown significant...
Microemulsion systems (MES) offer advantages as drug delivery systems, among them favour absorption, being in most case more efficient than other methods delivering of drug. In this work a new MES was obtained order to be applied pressurized aerosol formulation containing bee propolis ethanolic extract (PEE). For that, pseudoternary phase diagrams were used characterize the microemulsions boundaries and also define Winsor IV microemulsion region PEE-MES system Tween 80 surfactant...
Self-nanoemulsion drug delivery systems (SNEDDS) represent a potential carrier to improve solubility and bioavailability of health care products.In this sense, copaiba oil (CO) loaded on cosurfactant-free SNEDDS formulations (CO-SNEDDS) were obtained by using phase diagram performed different concentrations constituents (oil, surfactant water).The CO-SNEDDS are composed 1% (m/m) phase, 20% Tween 80, 79% doubledistilled water.Specifically, varying the CO affords so-called SNECO system,...
The stem bark of Anacardium occidentale L. (Anacardiaceae), commonly called cashew, is used in Brazilian traditional medicine for the treatment gastric and inflammatory disorders. present study was carried out to investigate vivo anti-inflammatory activities acetone extract (AE) A. occidentale. We evaluated pharmacological this plant material through analgesic, antiedematogenic chemotaxic inhibitory effects produced by AE. oral administration (p.o.) mice with AE (0.1, 0.3 1.0 g/kg) or...
The aim of this study was the encapsulation trans-dehydrocrotonin (t-DCTN) and its inclusion complexes with hydropropyl-beta-cyclodextrin (HP-beta-CD) in liposomes to improve t-DCTN antitumor activity. vitro kinetic profiles t-DCTN-loaded (LD) t-DCTN:HP-beta-CD-loaded (LC) were evaluated using dialysis technique. activity LD LC investigated against Sarcoma 180 Swiss mice. Histopathological hematological analyses carried out. amounts t-DCTN:HP-beta-CD complex encapsulated equivalent 1 mg...
Aim: The objective of this study was to assess in rats the antidiabetic effects (i.e. reduction hyperglycaemia and hypertriglyceridaemia) trans ‐dehydrocrotonin ( t ‐DCTN), a bioactive diterpene isolated from popular medicinal plant Croton cajucara . Methods: Hyperglycaemia induced by intraperitoneal injection streptozotocin (STZ) hypertriglyceridaemia oral administration ethanol rats. blood glucose levels were measured oxidase method using commercially available enzyme kits. Results:...
Nowadays, one of the main objectives biotechnological development new products is linked to processes and methods improvement. In this sense, aim work promote sustainable residue obtained from cashew´s organic reject material aiming at produce a target flour be applied as functional food. fact, nutritional composition cashew showed an important food profile related fibers carbohydrates. relation prepared simple possibility, cookies were produced, its sensorial characteristics carried out in...
Este trabalho objetivou a obtenção de óleos fixos (OF) das cascas do caule Croton cajucara via percolação [seguido fracionamento em coluna cromatográfica (CC)] e fluido supercrítico (FS, gás CO2), bem como avaliação propriedades fungicidas OF obtido pelo procedimento CC. Os OF-CC OF-FS apresentaram rendimentos significativamente diferentes; houve maior rendimento (3,14%) no processo convencional (OF-CC), versus 1,2% OF-FS. A fração F1 após esterificação, as frações não-esterificadas F2, F3...
Croton cajucara Beth (Euphorbiaceae) uma espécie medicinal nativa da região Amazônica do Brasil, onde é vulgarmente conhecida como 'sacaca', representa um recurso terapêutico eficaz no tratamento e cura de várias doenças. O metabólito majoritário trans-desidrocrotonina (DCTN), isolado das cascas caule desta planta, encontra-se correlacionado com grande parte propriedades medicinais sacaca. Este artigo revisão, descreve os resultados fitoquímicos farmacológicos que foram realizados o...
The clerodane-type diterpene, trans-dehydrocrotonin (1) the major component of Croton cajucara has shown striking correlation with its therapeutic use in traditional folk medicine. Phytochemical investigations led to isolation metabolites 1, cajucarinolide (6), isocajucarinolide (7), trans-crotonin (2), trans-cajucarin B (3), cis-cajucarin (4), A (5), N-methyltyrosine, vanillic acid and 4-hydroxy-benzoic acid. 6 7 were synthesized good yield by regiospecific oxidation 1 using singlet-oxygen....
Abstract The clerodane diterpene trans-dehydrocrotonin extracted and isolated from the stem bark of Croton cajucara Benth. was investigated for its lipid-lowering effect in mice fed on a high-fat diet. Mice diet two-week period demonstrated significantly increased blood levels total cholesterol triglycerides, compared with normal controls. Oral treatment at dose 25 or 50 mg kg−1 daily markedly suppressed high-fat-diet associated rise triglyceride levels. hypocholesterolaemic more prominent...
The growing demand for energy and the concern about environmental impacts reinforce necessity renewable sources such as biofuels. In this study, cake generated in babassu oil extraction was evaluated a potential feedstock solid biofuel production, it contains blend of cashew nutshell, sugarcane bagasse, carnauba straw, stalk. All samples were characterized by proximate analysis Higher Heating Value. Carbonization used to improve performance compaction understand mechanism characteristics...
The genotoxic action of three doses trans-dehydrocrotonin (t-DCTN), an active ingredient obtained from the bark extracts Amazon native plant, Croton cajucara, were examined in Swiss mouse bone marrow cells vivo, submitted to acute intraperitoneal treatment, by micronucleus (MN) and chromosomal aberration (CA) tests. statistical tests (Anova Tukey) made compare results each t-DCTN with negative-control group showed that frequencies MN mitotic index equal CA lower than observed...
The plant Croton cajucara Benth. (Euphorbiaceae) is a medicinal from the Brazilian Amazon where it commonly known as sacaca. principal compound isolated C. stem-bark extracts clerodane-type diterpene trans-dehydrocrotonin (DCTN) which presents several biological activities, including antiulcerogenic, anti-inflammatory, hypoglycemic, antimutagenic and antitumoral activity. However, few studies have been carried out to evaluate therapeutic potential of raw extracts. We studied mutagenicity...
Pharmacognosy Magazine,2017,13,50,265-269.DOI:10.4103/0973-1296.204557Published:April 2017Type:Original ArticleAuthors:Silvana Amadeu Ferreira Alves Monteath, Maria Aparecida M Maciel, Raquel Garcia Vega, Heloisa de Mello, Carollina Araújo Martins, Andressa Esteves-Souza, Cerli Rocha Gattass, and Aurea Echevarria Author(s) affiliations:Silvana Monteath1, Maciel2, Vega3, Mello4, Martins5, Esteves-Souza1, Gattass5, Echevarria1 1Departamento Química, ICE, Universidade Federal Rural do Rio...