A5082107048- Heavy Metal Exposure and Toxicity
- Carcinogens and Genotoxicity Assessment
- Mercury impact and mitigation studies
- Heavy metals in environment
- Air Quality and Health Impacts
- Antioxidant Activity and Oxidative Stress
- Epigenetics and DNA Methylation
- Trace Elements in Health
- Selenium in Biological Systems
- Free Radicals and Antioxidants
- Genomics, phytochemicals, and oxidative stress
- Dye analysis and toxicity
- Essential Oils and Antimicrobial Activity
- Pharmaceutical and Antibiotic Environmental Impacts
- Toxic Organic Pollutants Impact
- Microplastics and Plastic Pollution
- Heavy Metals in Plants
- Glutathione Transferases and Polymorphisms
- Bladder and Urothelial Cancer Treatments
- Plant Genetic and Mutation Studies
- Ginkgo biloba and Cashew Applications
- Mycotoxins in Agriculture and Food
- Environmental Toxicology and Ecotoxicology
- Phytochemistry Medicinal Plant Applications
- Bee Products Chemical Analysis
Universidade Federal de São Paulo
2016-2024
Universidade de São Paulo
2009-2019
Medical University of Vienna
2012
San Fernando General Hospital
2011
Instituto de Ciências Farmacêuticas
2008
Universidade Estadual de Londrina
2007
Universidade de Franca
2006
Previous studies showed that lead (Pb) exposure may modulate gene expression by changes in the epigenetic status. However, little is known about impact of Pb and alterations on DNA methylation patterns humans exposed to this metal. The aim study was assess consequences global methylation, order gain a better understanding interactions between effects. included 100 male workers employed automotive battery factories from Paraná State, Brazil. Concentrations blood (B-Pb) plasma (P-Pb) were...
Several epidemiological and experimental studies has been reported that lutein (LT) presents antioxidant properties. Aim of the present study was to investigate protective effects LT against oxidative stress DNA damage induced by cisplatin (cDDP) in a human derived liver cell line (HepG2). Cell viability DNA-damage monitored MTT comet assays. Moreover, different biochemical parameters related redox status (glutathione, cytochrome-c intracellular ROS) were also evaluated. A clear seen with...
The flavonoid quercetin and its derivative rutin were investigated for genotoxicity/antigenotoxicity activity in human hepatoma HepG2 cells using the comet assay. extract cytotoxicity was evaluated trypan blue exclusion dye method with concentrations ranging from 0.1 to 200.0 μg/mL of culture medium. Three minor non‐cytotoxic chosen evaluate genotoxicity antigenotoxicity flavonoids (0.1, 1.0 5.0 μg/mL) through cultures treated three different or (genotoxicity) their association Aflatoxin B1...
Chamomile is a medicinal plant, which presents several biological effects, especially the anti-inflammatory effect. One of compounds related to this effect apigenin, flavonoid that mostly found in its glycosylated form, apigenin-7-glucoside (APG), natural sources. However, affectivity and safety glycoside have not been well explored for topical application. In context, aim work was develop validate reversed-phase high-performance liquid chromatography (RP-HPLC-DAD) method quantify APG...
The use of phytochemicals has been widely used as inexpensive approach for prevention diseases related to oxidative damage due its antioxidant properties. One dietary flavonoids is chrysin (CR), found mainly in passion fruit, honey, and propolis. Methylmercury (MeHg) a toxic metal whose main mechanism damage. Thus, the study aimed evaluate effects CR against induced by MeHg Wistar rats. Animals were treated with (30 µ g/kg/bw) presence absence (0.10, 1.0, 10 mg/kg/bw) gavage 45 days....
Silybin (SB), a constituent of the medicinal plant Silybum marianum, is reported to be potent hepatoprotective agent, but little currently known regarding its genotoxicity, mutagenicity and potential chemopreventive properties. In this study, we evaluated ability SB induce DNA migration micronuclei (MN) formation in human hepatoma cells (HepG2). Also, possible preventive effects on MN induced by three different mutagens, bleomycin (BLEO), benzo[a]pyrene (B[a]P) aflatoxin B1 (AFB1), were...
Abstract Populations in the Amazon are exposed to organic mercury via consumption of contaminated foods. These ethnic groups consume a specific plant seed “annatto” which contains certain carotenoids. The aim this study was find out if these compounds (bixin, BIX and norbixin, NOR), protect against DNA‐damage caused by metal. Therefore, rats were treated orally with methylmercury (MeHg) carotenoids under conditions that relevant humans. animals either MeHg (30 μg/kg/bw/day), (0.1–10...
This study aims to evaluate the effects of polymorphisms in glutathione (GSH-) related genes ( GSTM1 , GSTT1 GSTP1 GCLM and GCLC ) distribution Hg blood compartments humans exposed methylmercury (MeHg). Subjects (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mi>n</mml:mi><mml:mo>=</mml:mo><mml:mn>88</mml:mn></mml:math>), MeHg from fish consumption, were enrolled study. species plasma compartment determined by LC-ICP-MS, whereas genotyping was performed PCR assays....
Over the last decades, presence of methylmercury (MeHg) in Amazon region Brazil and its adverse human health effects have given rise to much concern. The biotransformation MeHg occurs mainly through glutathione (GSH) bile mediated by conjugation with S-transferases (GST). Epidemiological evidence has shown that genetic polymorphisms may affect metabolism MeHg. aim this study was evaluate association between GST polymorphisms, GSH, Hg levels blood (B-Hg) hair (H-Hg) an population chronically...
AbstractLead (Pb) is a toxic metal that widely used by metallurgical industries such as car battery recycling. Exposure to the may modify redox status of cells and consequently result in changes activities important enzymes delta-aminolevulinic acid dehydratase (ALAD) glutathione peroxidase (GPx). Similarly, genetic polymorphisms modulate related detoxification processes Pb body burden. Therefore, aims present study were (i) evaluate correlation between blood lead levels (BLL) ALAD GPx, (ii)...
Lead (Pb) is a metal that accumulates in the human body, inducing several adverse health effects. One of proteins responsible for distribution body metallothionein (MT), which expressed by different genes, and it supposed genetic variation genes encode MTs may affect Pb burden. The present study aimed to evaluate effects polymorphism MT2A (single nucleotide rs10636; Cx2192;G) on blood levels (BLL) workers from car battery factories who are chronically exposed metal. In total, 221 men...