A5017659253- Heavy Metal Exposure and Toxicity
- Telomeres, Telomerase, and Senescence
- Heavy metals in environment
- Iron Metabolism and Disorders
- Carcinogens and Genotoxicity Assessment
- Epigenetics and DNA Methylation
- Hemoglobinopathies and Related Disorders
- Mesenchymal stem cell research
- Environmental Justice and Health Disparities
- Mercury impact and mitigation studies
- Digestive system and related health
- Trace Elements in Health
- Liver physiology and pathology
- IL-33, ST2, and ILC Pathways
- Tissue Engineering and Regenerative Medicine
- Single-cell and spatial transcriptomics
Universidade de São Paulo
2016-2024
Universidade de Ribeirão Preto
2024
Previous studies showed that lead (Pb) exposure may modulate gene expression by changes in the epigenetic status. However, little is known about impact of Pb and alterations on DNA methylation patterns humans exposed to this metal. The aim study was assess consequences global methylation, order gain a better understanding interactions between effects. included 100 male workers employed automotive battery factories from Paraná State, Brazil. Concentrations blood (B-Pb) plasma (P-Pb) were...
Occupational exposure to lead (Pb) continues be a serious public health concern and may pose an elevated risk of genetic oxidative damage. In Brazil, car battery manufacturing recycling factories represent great source Pb contamination, there are no guidelines on how properly protect workers from or dispose the process wastes. Previous studies have shown that body burden is associated with polymorphisms, which consequently influence toxicity metal. The aim this study was assess impact DNA...
Introduction: Beta-thalassemia is caused by a deficient synthesis of the ß-chain hemoglobin, which leads to chronic, microcytic and hypochromic anemia.More than 200 mutations have already been associated with this type thalassemia, their frequencies may vary according population.Objectives: The objectives study were determine CD39, IVS1-1, IVS1-6 IVS1-110 in people beta-thalassemia from city Franca, São Paulo, evaluate influence genotypes on hematological alterations.Methods: Venous blood...