A5059912571- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Iron Metabolism and Disorders
- Hemoglobinopathies and Related Disorders
- Eosinophilic Disorders and Syndromes
- Alkaline Phosphatase Research Studies
- Mesenchymal stem cell research
- Venomous Animal Envenomation and Studies
- Extracellular vesicles in disease
- Cancer Cells and Metastasis
- Hippo pathway signaling and YAP/TAZ
- Chronic Myeloid Leukemia Treatments
- Kruppel-like factors research
- Selenium in Biological Systems
- Biochemical and Molecular Research
- Sarcoma Diagnosis and Treatment
- Inflammasome and immune disorders
- Adenosine and Purinergic Signaling
- Pluripotent Stem Cells Research
- Bone and Joint Diseases
- Quinazolinone synthesis and applications
- Macrophage Migration Inhibitory Factor
- Cell death mechanisms and regulation
- interferon and immune responses
- Mast cells and histamine
- Wnt/β-catenin signaling in development and cancer
Hospital Universitário da Universidade de São Paulo
2025
Universidade de Ribeirão Preto
2014-2024
Universidade de São Paulo
2014-2024
Dr. Euryclides Hospital de Jesus Zerbini
2021
State Hospital
2021
Instituto de Ciências Farmacêuticas
2021
Universidade Federal de Juiz de Fora
2021
Clinics Hospital of Ribeirão Preto
2019
The exceptional biocompatibility of polymeric membranes drives their use in biomaterials, but structural modifications are needed to improve mechanical properties. This study investigated dry heating treatment (DHT) as an ecofriendly and cost-effective approach modifying potato starch for biomembrane fabrication. DHT-treated (2 h) produced biomembranes with a denser structure, smoother surfaces, significantly improved properties, including higher tensile strength (∼6×), rigidity (∼15×),...
Cytokines are key immune mediators in physiological and disease processes, whose increased levels have been associated with the physiopathology of hematopoietic malignancies, such as myeloproliferative neoplasms.This study examined plasma cytokine profiles patients essential thrombocythemia, primary myelofibrosis, polycythemia vera healthy subjects, analyzed correlations JAK2 V617F status clinical-hematological parameters.The proinflammatory were neoplasm patients, presence mutation was high...
The thalassemia syndromes (α- and β-thalassemia) are the most common frequent disorders associated with ineffective erythropoiesis. Imbalance of α- or β-globin chain production results in impaired red blood cell synthesis, anemia, more erythroid progenitors stream. While patients affected by these show definitive altered parameters related to erythropoiesis, relationship between degree dysfunctional iron metabolism has not been investigated both α-thalassemia carriers (ATC) β-thalassemia...
Background Essential thrombocythemia (ET), polycythemia vera (PV), and primary myelofibrosis (PMF) are clonal hematological diseases classified as Philadelphia chromosome-negative myeloproliferative neoplasms (MPN). MPN pathogenesis is associated with the presence of somatic driver mutations, bone marrow (BM) niche alterations, tumor inflammatory status. The relevance soluble mediators in led us to analyze levels cytokines, chemokines, growth factors related inflammation, angiogenesis...
Background: Resistance to apoptosis in chronic myeloid leukemia (CML) is associated with constitutive tyrosine kinase activity of the Bcr-Abl oncoprotein. The deregulated expression apoptosis-related genes and alteration epigenetic machinery may also contribute resistance CML. Tyrosine inhibitors target oncoprotein are used CML treatment. patients has guided search for new compounds that induce Bcr-Abl+ leukemic cells improve disease Methods: In present study, we investigated whether L-amino...
Abstract Polycythemia vera (PV) is a clonal disorder resulting from neoplastic transformation of hematopoietic stem cells, while secondary polycythemia (SP) disease characterized by increased absolute red blood cell mass caused stimulation production. Although the physiopathology SP and PV distinct, patients with these diseases share similar symptoms. The early differential diagnosis may improve quality life decrease burden in patients, as well enable curative treatment for patients....
Mineralizing cells release a special class of extracellular vesicles known as matrix (MV), crucial for bone mineralization. Following their release, MV anchor to the (ECM), where highly specialized enzymatic machinery facilitates formation seed mineral within MV's lumen, subsequently releasing it onto ECM. However, how propagate collagenous ECM remains unclear. In this study, we address these questions by exploring "protein corona" paradigm whereby nanoparticles entering biological milieu...
Introduction: Beta-thalassemia is caused by a deficient synthesis of the ß-chain hemoglobin, which leads to chronic, microcytic and hypochromic anemia.More than 200 mutations have already been associated with this type thalassemia, their frequencies may vary according population.Objectives: The objectives study were determine CD39, IVS1-1, IVS1-6 IVS1-110 in people beta-thalassemia from city Franca, São Paulo, evaluate influence genotypes on hematological alterations.Methods: Venous blood...
Abstract Myeloproliferative neoplasms (MPN) are hematological disorders characterized by increased proliferation of precursor and mature myeloid cells. MPN patients may present driver mutations in JAK2 , MPL CALR genes, which essential to describe the molecular mechanisms pathogenesis. Despite all new knowledge on pathogenesis, many questions remain be answered develop effective therapies cure or impair its progression acute leukemia. The study examined expression levels Hippo signaling...