A5007783956- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Chronic Myeloid Leukemia Treatments
- HIV Research and Treatment
- Kruppel-like factors research
- HIV-related health complications and treatments
- Venomous Animal Envenomation and Studies
- Eosinophilic Disorders and Syndromes
- Chronic Lymphocytic Leukemia Research
- Hippo pathway signaling and YAP/TAZ
- Acute Myeloid Leukemia Research
- HIV/AIDS Research and Interventions
- Cell death mechanisms and regulation
- Mast cells and histamine
- interferon and immune responses
- Immune Cell Function and Interaction
- Salmonella and Campylobacter epidemiology
- Synthesis and Characterization of Heterocyclic Compounds
- Mesenchymal stem cell research
- Wnt/β-catenin signaling in development and cancer
- Cytomegalovirus and herpesvirus research
- Platelet Disorders and Treatments
- Healthcare and Venom Research
- Bone and Joint Diseases
- Quinazolinone synthesis and applications
- PI3K/AKT/mTOR signaling in cancer
Universidade de Ribeirão Preto
2017-2023
Universidade de São Paulo
2015-2023
Dr. Euryclides Hospital de Jesus Zerbini
2021
State Hospital
2021
Instituto de Ciências Farmacêuticas
2021
Universidade Federal de Juiz de Fora
2021
Inserm
2017-2020
Institut Gustave Roussy
2017-2020
Cytokines are key immune mediators in physiological and disease processes, whose increased levels have been associated with the physiopathology of hematopoietic malignancies, such as myeloproliferative neoplasms.This study examined plasma cytokine profiles patients essential thrombocythemia, primary myelofibrosis, polycythemia vera healthy subjects, analyzed correlations JAK2 V617F status clinical-hematological parameters.The proinflammatory were neoplasm patients, presence mutation was high...
Abstract Monocytes are key cells in the immune dysregulation observed during human immunodeficiency virus (HIV) infection. The events that take place specifically monocytes may contribute to systemic dysfunction characterized by excessive activation infected individuals, which directly correlates with pathogenesis and progression of disease. Here, we investigated from untreated treated HIV + patients associated these findings epigenetic changes. showed dysfunctional ability phagocytosis...
Abstract Somatic mutations in the calreticulin ( CALR ) gene are associated with approximately 30% of essential thrombocythemia (ET) and primary myelofibrosis (PMF). mutations, including two most frequent 52 bp deletion del52 5 insertion ins5 ), induce a frameshift to same alternative reading frame generating new C-terminal tails. In patients, phenotypically distinct myeloproliferative neoplasms (MPNs). They equally found ET, but is more PMF. We generated heterozygous homozygous conditional...
Chronic myeloid leukemia (CML) is a BCR-ABL1+ myeloproliferative neoplasm marked by increased myeloproliferation and presence of leukemic cells resistant to apoptosis. The current first-line therapy for CML administration the tyrosine kinase inhibitors imatinib mesylate, dasatinib or nilotinib. Although effective treat CML, some patients have become this therapy, leading disease progression death. Thus, discovery new compounds improve still challenging. Here we addressed whether MjTX-I,...
Chronic myeloid leukemia (CML) is a clonal myeloproliferative neoplasm whose pathogenesis linked to the Philadelphia chromosome presence that generates BCR-ABL1 fusion oncogene. Tyrosine kinase inhibitors (TKI) such as imatinib mesylate (IM) dramatically improved treatment efficiency and survival of CML patients by targeting BCR-ABL tyrosine kinase. The disease shows three distinct clinical-laboratory stages: chronic phase, accelerated phase blast crisis. Although in respond well treatment,...
Background Essential thrombocythemia (ET), polycythemia vera (PV), and primary myelofibrosis (PMF) are clonal hematological diseases classified as Philadelphia chromosome-negative myeloproliferative neoplasms (MPN). MPN pathogenesis is associated with the presence of somatic driver mutations, bone marrow (BM) niche alterations, tumor inflammatory status. The relevance soluble mediators in led us to analyze levels cytokines, chemokines, growth factors related inflammation, angiogenesis...
Three decades after HIV recognition and its association with AIDS development, many advances have emerged – especially related to prevention treatment. Undoubtedly, the development of Highly Active Antiretroviral Therapy (HAART) dramatically changed future syndrome that we know today. In present study, evaluate impact on macrophage function relevance pathogenesis. PBMCs were isolated from blood samples monocytes (CD14+ cells) purified. Monocyte-Derived Macrophages (MDMs) activated classical...
Background Successful highly active antiretroviral therapy (HAART) has changed the outcome of AIDS patients worldwide because complete suppression viremia improves health and prolongs life expectancy HIV-1+ patients. However, little attention been given to immunological profile under distinct HAART regimens. This work aimed investigate differences in pattern first- or second-line Brazil. Methods CD4+ T cell counts, Viral load, plasma concentration sCD14, sCD163, MCP-1, RANTES, IP-10, IL-1β,...
Background: Resistance to apoptosis in chronic myeloid leukemia (CML) is associated with constitutive tyrosine kinase activity of the Bcr-Abl oncoprotein. The deregulated expression apoptosis-related genes and alteration epigenetic machinery may also contribute resistance CML. Tyrosine inhibitors target oncoprotein are used CML treatment. patients has guided search for new compounds that induce Bcr-Abl+ leukemic cells improve disease Methods: In present study, we investigated whether L-amino...
Summary Progression to aggressive secondary acute myeloid leukaemia (sAML) poses a significant challenge in the management of myeloproliferative neoplasms (MPNs). Since physiopathology MPN is closely linked activation interferon (IFN) signalling and that AML initiation aggressiveness driven by stem cells (LSCs), we investigated these pathways sAML progression. We found high IFN correlated with low LSC samples, while progression transformation were characterized decreased increased signature....
The HIV/AIDS pandemic still represents an important global health issue. There is no sterilizing cure, therefore a continuous treatment necessary, which caused the emerged idea of HIV as chronic inflammatory disease that may also affect healthy aging. Considering activation profile some innate cells such natural killer has previously been associated to progression, it remains be better defined this status NK considering time infection. In study, we characterized cell phenotype and function...
Chronic myelogenous leukemia (CML) is a myeloproliferative neoplasm that expresses the Philadelphia chromosome and constitutively activated Bcr-Abl tyrosine kinase in hematopoietic progenitor cells. tyrosine-kinase inhibitors (TKI) do not definitively cure all CML patients. The efficacy of TKI reduced patients blastic phase-the most severe phase disease-and resistance to this drug has emerged. There limited knowledge on underlying mechanisms disease progression beyond BCR-ABL1, as well...
Abstract Polycythemia vera (PV) is a clonal disorder resulting from neoplastic transformation of hematopoietic stem cells, while secondary polycythemia (SP) disease characterized by increased absolute red blood cell mass caused stimulation production. Although the physiopathology SP and PV distinct, patients with these diseases share similar symptoms. The early differential diagnosis may improve quality life decrease burden in patients, as well enable curative treatment for patients....
Salmonella nontyphoidal is a major cause of foodborne illness in the world. The Enteritidis has being identified as most common serovar and responsible for gastroenteritis even systemic infections. In developing countries, Typhimurium Serovar invasive infections leading to death young children with underlying diseases also, adults infected HIV [1]. These bacteria can proliferate within epithelial cells non-activated macrophages, but by using specific mechanisms pathogenicity island SPI2,...
Abstract Chronic myeloid leukemia (CML) is a clonal myeloproliferative neoplasm linked to the Philadelphia chromosome presence that generates BCR-ABL1 fusion oncogene. Tyrosine kinase inhibitors (TKI) such as imatinib mesylate (IM) dramatically improved treatment efficiency and survival of CML patients by targeting BCR-ABL tyrosine kinase. Although in chronic phase respond well treatment, accelerated or blast crisis usually show therapy resistance relapse. It crucial, therefore, identify...