A5008007021- Chronic Myeloid Leukemia Treatments
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Venomous Animal Envenomation and Studies
- Chronic Lymphocytic Leukemia Research
- Eosinophilic Disorders and Syndromes
- Acute Myeloid Leukemia Research
- Kruppel-like factors research
- Cell death mechanisms and regulation
- Healthcare and Venom Research
- T-cell and Retrovirus Studies
- RNA Interference and Gene Delivery
- Hippo pathway signaling and YAP/TAZ
- Mast cells and histamine
- Autoimmune and Inflammatory Disorders Research
- Acute Lymphoblastic Leukemia research
- Erythrocyte Function and Pathophysiology
- Quinazolinone synthesis and applications
- Research on Leishmaniasis Studies
- interferon and immune responses
- Lymphoma Diagnosis and Treatment
- Antimicrobial Peptides and Activities
- Immune Cell Function and Interaction
- Mosquito-borne diseases and control
- Cytokine Signaling Pathways and Interactions
- Synthesis and Characterization of Heterocyclic Compounds
Universidade de São Paulo
2015-2024
University of Chile
2024
Universidade de Ribeirão Preto
2002-2023
University Health Network
2020-2023
Princess Margaret Cancer Centre
2020-2023
Associação de Medicina Intensiva Brasileira
2023
Roche (Switzerland)
2018-2021
Instituto de Ciências Farmacêuticas
2004-2021
Universidad de Los Andes, Chile
2021
Fundação Hemopa
2004-2020
Nonmelanoma skin cancer (NMSC) is the most common in Germany, but detailed information on survival lacking.To provide estimates for female and male patients with basal cell carcinoma (BCC), squamous (SCC), sarcoma, adenocarcinoma Merkel carcinoma. Further subgroup analyses were carried out by age, tumour stage body site.In total 459 640 diagnosed NMSC 1997-2011 included from population-based registers, covering a population of 33 million inhabitants. Age-standardized absolute relative 5-year...
Abstract L-amino acid oxidases from snake venoms have been described to possess various biological functions. In this study, we investigated the inflammatory responses induced in vivo and vitro by CR-LAAO, an oxidase isolated Calloselasma rhodostoma venom, its antitumor potential. CR-LAAO acute , with recruitment of neutrophils release IL-6, IL-1β, LTB 4 PGE 2 . IL-6 IL-1β production peritoneal macrophages stimulated was dependent activation Toll-like receptors TLR2 TLR4. addition, promoted...
Cytokines are key immune mediators in physiological and disease processes, whose increased levels have been associated with the physiopathology of hematopoietic malignancies, such as myeloproliferative neoplasms.This study examined plasma cytokine profiles patients essential thrombocythemia, primary myelofibrosis, polycythemia vera healthy subjects, analyzed correlations JAK2 V617F status clinical-hematological parameters.The proinflammatory were neoplasm patients, presence mutation was high...
Breast cancer is the neoplasm with both highest incidence and mortality rate among women worldwide. Given known snake venom cytotoxicity towards several tumor types, we evaluated effects of BthTX-I from Bothrops jararacussu on MCF7, SKBR3, MDAMB231 breast cell lines.BthTX-I was determined via MTT 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrazoliumbromide assay. Cell death measured by a hypotonic fluorescent solution method, annexin-V-FITC/propidium iodide staining apoptotic/autophagic...
Chronic myeloid leukaemia (CML) is a myeloproliferative disorder characterized by the presence of Philadelphia chromosome and BCR-ABL1, which encodes BCR-ABL oncoprotein. Although imatinib mesylate (IM) effective for CML treatment, patients in accelerated blastic phases disease are often refractory to this therapy, there also cases IM resistance chronic phase. Therefore, potential new drugs being investigated improve efficiency therapy such as snake venoms their compounds. In investigation,...
Tityus serrulatus scorpion venom (TsV) contains toxins that act on K(+) and Na(+) channels account for the venom's toxic effects. TsV can activate murine peritoneal macrophages, but its effects human lymphocytes have been poorly investigated. Considering may play an important role in envenomation, we assessed whether affects expression of phenotypic (CD3, CD4, CD8) activation (CD69, CD25, HLA-DR) markers, cell proliferation, cytokine production peripheral blood mononuclear cells.Cytotoxicity...
Background Chronic myeloproliferative disorders (MPDs) are clonal haematopoietic stem cell malignancies characterised by an accumulation of mature myeloid cells in bone marrow and peripheral blood. Deregulation the apoptotic machinery may be associated with MPD physiopathology. Aims To evaluate expression death receptors' family members, mononuclear apoptosis resistance, JAK2 allele burden. Subjects Methods Bone progenitor CD34 were separated using Ficoll-hypaque protocol followed Miltenyi...
Summary Type 1 diabetes (T1D) is a chronic autoimmune disease characterized by T cell-mediated destruction of pancreatic β cells, resulting in insulin deficiency and hyperglycaemia. Recent studies have described that apoptosis impairment during central peripheral tolerance involved T1D pathogenesis. In this study, the apoptosis-related gene expression patients was evaluated before after treatment with high-dose immunosuppression followed autologous haematopoietic stem cell transplantation...
Chronic myeloid leukemia (CML) is a BCR-ABL1+ myeloproliferative neoplasm marked by increased myeloproliferation and presence of leukemic cells resistant to apoptosis. The current first-line therapy for CML administration the tyrosine kinase inhibitors imatinib mesylate, dasatinib or nilotinib. Although effective treat CML, some patients have become this therapy, leading disease progression death. Thus, discovery new compounds improve still challenging. Here we addressed whether MjTX-I,...
Chronic myeloid leukemia (CML) is a clonal myeloproliferative neoplasm whose pathogenesis linked to the Philadelphia chromosome presence that generates BCR-ABL1 fusion oncogene. Tyrosine kinase inhibitors (TKI) such as imatinib mesylate (IM) dramatically improved treatment efficiency and survival of CML patients by targeting BCR-ABL tyrosine kinase. The disease shows three distinct clinical-laboratory stages: chronic phase, accelerated phase blast crisis. Although in respond well treatment,...
Defective apoptosis might be involved in the pathogenesis of multiple sclerosis (MS). We evaluated apoptosis-related molecules MS patients before and after autologous haematopoietic stem cell transplantation (AHSCT) using BCNU, Etoposide, AraC Melphalan (BEAM) or cyclophosphamide (CY)-based conditioning regimens. Patients were followed for clinical immunological parameters 2 years AHSCT. At baseline, had decreased proapoptotic BAD, BAX FASL increased A1 gene expression when compared with...