Although Ag-based materials are efficient against antibiotic-resistant bacteria, their high toxicity to living organisms represents a major challenge for obtaining useful products. In this work, we report the bactericidal activity of Ag4V2O7/β-AgVO3 heterostructures, which proved be effective Klebsiella pneumoniae (ATCC 1706, standard strain; A54970, multidrug-resistant carbapenemase (KPC)-producing A34057, strain capable producing extended spectrum beta-lactamases (ESBL); and...

Nanoparticles are resources of advanced nanotechnology being present in several products. Titanium dioxide nanoparticles among the five most widely used NP currently expanding their benefits from oil industry to areas diagnostic medicine due properties and small size. However, its impact on human health is still controversial literature. We aimed evaluate cytotoxicity a new titanium functionalized with sodium carboxylic ligand (COOH-Na+) keratinocytes (HaCaT) fibroblasts (HDFn).The...

Infections due to Candida spp., they are a threat global health, with high rates of morbidity and mortality their drug resistance, especially in immunocompromised people. Thus, the search for new alternatives is urgent today. In recent years, combined therapy compounds natural origin has been proposed as an alternative. Considering biological potential isoespintanol (ISO) continuing its study, objective this research was assess effect ISO combination antifungals, fluconazole (FLZ),...

Eosinophils are multifunctional cells that have cytotoxic proinflammatory activities and stimulate CD4+ T-cells in experimental models of allergy parasitic infections. Eosinophils, when exposed to antigens, activated, expressing the CD38/CD69 molecules exhibited increased expression Major Histocompatibility Complex (MHC-II), CD80 CD86, suggesting they play a role upon T. canis antigen stimulation. In present study, we evaluated profile eosinophils using conventional image flow cytometry...

Background/Aims: Cancer is the second most deadly disease in world. The bladder cancer one of aggressive types and shows a continuous increase number cases. use bacteria as live vectors to deliver molecules directly tumor promising tool has been used an adjuvant treatment against several cancer. aim this study was investigate antitumor effect Interleukin 2 (IL-2), TNF-related apoptosis-inducing ligand (TRAIL) protein MIX murine cells, lineage MB49. Methods: attenuated Salmonella strain...

BACKGROUND/AIMS: A new type of nanoparticle, called NP CB-EDA (Black Carbon modified with ethylenediamine), is commonly used in the oil industry. In literature, few studies are found biological models, making NP-EDA potential cytotoxicity organisms unclear. As its large surface area capable interacting system, that interaction could lead to factors harmful health. The objective this study was investigate cytotoxic effect on fibroblasts LA-9 at 24 and 48 hours, different concentrations...

Titanium dioxide nanoparticles (TiO2 NPs) are extensively applied in the industry due to their photocatalytic potential, low cost, and considerably toxicity. However, new unrelated physicochemical properties wide use of brought concern about toxic effects. Thereby, we evaluated cytotoxicity a TiO2 NP composed anatase functionalized with sodium carboxylate ligands murine fibroblast cell line (LA-9).Scanning Electron Microscopy (SEM), Dynamic Light Scattering (DLS), ATR-FTIR spectroscopy were...

The search for new nanomaterials has brought to the multifactorial industry several opportunities use and applications existing materials. Carbon nanotubes (CNT), example, present excellent properties which allow us assume a series of applications, however there is concern in industrial scope about possible adverse health effects related constant exposure inhalation or direct skin contact. Thus, using cell models fastest safest way assess material. aim this study was investigate cytotoxic...

The extensive use of titanium dioxide nanoparticles (TiO2 NPs) in cosmetics, food, personal care products, and industries brought concerns about their possible harmful effects. Nowadays it has become important to assess TiO2 NPs toxic effects as a way understand primary risks. In the cellular environment, after cell uptake, were described induce reactive oxygen species (ROS) production, unbalance oxidative state, activate apoptosis several lines. Therefore, we aimed evaluate cytotoxicity...

The influence of black carbon nanoparticles on J774.A1 murine cells was investigated with the objective exploring cytotoxicity functionalized ethylenediamine CB-EDA. results showed that CB-EDA has a cytotoxic profile for macrophages in time- and dose-dependent manner. When phagocytosed by macrophage, triggers mechanism leads to apoptosis. In this process, there is an increase oxidative stress pathways due activation nitric oxide then ROS. This causes imbalance redox function disruption...

Background: Prominent among all the organisms that have a potential value for production of new medicines, are endophytes, fungi and bacteria live inside plants without harming them. In this study, total lyophilized extract (TLE) Paenibacillus polymyxa RNC-D was used. The P. lineages known their capacity to segregate large number extracellular enzymes bioactive substances. Methods: TLE tested in cell viability assays cytotoxicity cytokine BALB/3T3 J774A.1 lineages. Results: A 50% mortality...

BACKGROUND/AIMS: The development of new nanomaterials has been growing in recent decades to bring benefits several areas, especially carbon-based nanoparticles, which have unique physical-chemical properties and allow take on applications. Consequently, the use without previous toxicological studies raises concern about possible harmful health effects. aim this study was investigate cytotoxic profile a multi-walled carbon nanotube (MWCNT) functionalized with tetraethylenepentamine called...

sp. infections are a threat to global health, with high morbidity and mortality rates due drug resistance, especially in immunocompromised people. For this reason, the search for new alternatives is urgent, recent years, combined therapy natural compounds has been proposed. Considering biological potential of isoespintanol (ISO) continuing its study, objective research was assess effect ISO combination antifungals fluconazole (FLZ), amphotericin B (AFB) caspofungin (CASP) against clinical isolates

Nanotechnology in medicine represents a revolution offering significant advancements the diagnosis, treatment, and prevention of diseases. This technology enables development devices materials at nanometer scale, allowing precise interactions with biological systems molecular cellular levels. Among various nanomaterials, carbon nanotubes (CNTs) stand out due to their unique physical, chemical mechanical properties. Due high strength, electrical thermal conductivity large surface area, CNTs...

Bladder cancer presents a significant health challenge due to its high malignancy and rising incidence rates. Silver-based materials are well-known for their cytotoxic effects on various cell types. This study not only aimed synthesize characterize carbon-supported WO3:Ag heterostructures but also evaluate biological physicochemical properties. The material was synthesized through the synergistic thermal decomposition of α-Ag2WO4 dispersed in chitosan, followed by heterostructure formation...

Leishmaniases are diseases with high epidemiological relevance and wide geographical distribution. In Brazil, Leishmania (Leishmania) amazonensis is related to the tegumentary form of leishmaniasis. The treatment for those problematic as available drugs promote adverse effects in patients. Therefore, it important find new therapeutic targets. this regard, one alternative study biomolecules produced by endophytic microorganisms. study, total extract Paenibacillus polymyxa RNC-D was used...

The increase in large-scale production of magnetic nanoparticles (NP) associated with the incomplete comprehensive knowledge regarding potential risks their use on environmental and human health makes it necessary to study biological effects these particles organisms at cellular level. aim this examine fibroblast lineage LA-9 after exposure mixed iron oxide NP (Fe3O4 NP). following analyses were performed: field emission gun–scanning electron microscopy (SEM-FEG), dynamic light scattering...

Background/Aims: Carbon Black (CB) is the most widely produced and commercially used nanocarbon. Growing evidence links nanomaterials to adverse effects, arising from their large surface area capable of interacting with biological systems. Due variety applications human exposures nanoparticles, it important assess potential health risk understand underlying mechanisms toxicity. The present study aims investigate cytotoxic effect black nanoparticle covalently linked ethylenediamine (CB-EDA)...