A5058185753- Immune Response and Inflammation
- Phagocytosis and Immune Regulation
- Immunotherapy and Immune Responses
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Immune Cell Function and Interaction
- Immune responses and vaccinations
- Birth, Development, and Health
- Probiotics and Fermented Foods
- Parasites and Host Interactions
- COVID-19 Clinical Research Studies
- Pregnancy and preeclampsia studies
- Wound Healing and Treatments
- Immune cells in cancer
- Gestational Diabetes Research and Management
- Liver Disease Diagnosis and Treatment
- Galectins and Cancer Biology
- Microbial Natural Products and Biosynthesis
- Genetic Syndromes and Imprinting
- Gut microbiota and health
- Bioactive Compounds and Antitumor Agents
- COVID-19 and healthcare impacts
- NF-κB Signaling Pathways
- Adenosine and Purinergic Signaling
- Liver Disease and Transplantation
- Biochemical and biochemical processes
Universidade Federal da Paraíba
2021-2025
Universidade de São Paulo
2014-2023
Indiana University – Purdue University Indianapolis
2016-2018
Indiana University School of Medicine
2016-2018
Universidade Estadual Paulista (Unesp)
2014-2018
University of Maryland, College Park
2018
University of Alabama at Birmingham
2018
University at Buffalo, State University of New York
2018
Public and Science
2018
Michigan United
2018
The COVID-19 pandemic has caused a global crisis, overwhelming hospitals and intensive care units (ICU) leading to an increase in nosocomial infections due prolonged hospitalization other risk factors. present study evaluated the prevalence of secondary fungal critically ill patients with COVID-19. This is retrospective, single-center conducted hospital northeastern Brazil, which 1,364 medical records admitted ICU during 2020 2021. A total 327 pathogenic yeasts were isolated from 132 (40.4%)...
Background Some probiotic strains have the potential to assist in relieving symptoms of inflammatory bowel disease. The impact daily ingestion a soy-based product fermented by Enterococcus faecium CRL 183 and Lactobacillus helveticus 416 with addition Bifidobacterium longum ATCC 15707 on chemically induced colitis has been investigated thereof within period 30 days. Methods Colitis was dextran sulfate sodium. animals were randomly assigned into five groups: Group C: negative control; CL:...
Poorly controlled diabetes leads to comorbidities and enhanced susceptibility infections. While the immune components involved in wound healing have been studied, skin infections remain unclear. Here, we examined effects of inflammatory lipid mediator leukotriene B4 (LTB4) signaling through its receptor B 1 (BLT1) progression methicillin-resistant Staphylococcus aureus (MRSA) infection 2 models diabetes. Diabetic mice produced higher levels LTB4 skin, which correlated with larger nonhealing...
Abstract Background Arachidonate‐5‐lipoxygenase (5‐LO) activity and increased leukotriene B4 (LTB4) production have been implicated in various inflammatory conditions. Increased of leukotrienes has associated with periodontal diseases; however, their relative contribution to tissue destruction is unknown. In this study, an orally active specific 5‐LO inhibitor used assess its role inflammation bone resorption a murine model lipopolysaccharide (LPS)‐induced disease. Methods Periodontal...
Significance Citrobacter rodentium infection, a murine colitis model to study human intestinal diseases, causes exacerbated apoptosis of epithelial cells and triggers Th17 immune responses. Here, we identified heretofore unknown role for the bioactive lipid mediator prostaglandin E 2 (PGE ) in inhibition cell differentiation during C. infection. When PGE receptor EP4 was antagonized, detected enhanced colonic cells, increased expression antimicrobial peptides, decreased bacterial numbers...
People with diabetes are more prone to Staphylococcus aureus skin infection than healthy individuals. Control of S. depends on dendritic cell (DC)–induced T-helper 17 (Th17)–mediated neutrophil recruitment and bacterial clearance. DC ingestion infected apoptotic cells (IACs) drive prostaglandin E2 (PGE2) secretion generate Th17 cells. We speculated that hyperglycemia inhibits migration the lymph nodes impairs differentiation accounts for poor host defense in diabetic mice. Diabetic mice...
Very little is known about the immunomodulatory potential of secondary metabolites isolated from marine microorganisms. In present study, we characterized pyrenocine A, which produced by marine-derived fungus Penicillium paxilli Ma(G)K and possesses anti-inflammatory activity. Pyrenocine A was able to suppress, both pretreatment posttreatment, LPS-induced activation macrophages via inhibition nitrite production synthesis inflammatory cytokines PGE2. also exhibited effects on expression...
Probiotics have been shown to a beneficial effect on allergic diseases. Anti-allergic of Lacticaseibacillus paracasei was demonstrated in asthma, however, its combined rhinitis and asthma syndrome (CARAS) is still unclear. This study evaluated the (LPc-G110) supplementation CARAS mice model. BALB/c were ovalbumin-sensitized challenged after being supplemented with LPc-G110. Supplemented animals showed reduced signs, eosinophilic infiltration, mucus, extracellular matrix deposition into...
This study was performed to identify predictive markers of worse outcomes in patients with severe COVID-19 an intensive care unit.
Efferocytosis, or clearance of apoptotic cells (ACs), by dendritic (DCs) leads to immune response suppression and tolerance self-antigens. However, efferocytosis infected (IACs) the production a mixed pro- anti-inflammatory cytokine milieu. We examined DC phenotype ability migrate after phagocytosis ACs IACs observed higher levels CD86 CCR7 expression in DCs, as well enhanced migration capacity following IACs. Interestingly, interleukin-1β, interleukin-10 prostaglandin E2 (PGE2 ) were also...
Background/Objectives: Acute lung injury (ALI) is an inflammatory disorder affecting patients in intensive care with high mortality. No specific pharmacological treatment available. Musa paradisiaca L. (banana) a cosmopolitan plant, and homemade syrup from its inflorescence used many countries to treat pulmonary inflammation. Therefore, this study analyzed the hydroalcoholic extract (HEM) of on ALI experimental model. Methods: Swiss mice were challenged lipopolysaccharide treated HEM after...
Imprinted genes are important for the offspring development. To assess relationship between obesity-related H19DMR methylation and H19 IGF2 gene expression growth body composition.Thirty-nine overweight/obese 25 normal weight pregnant women were selected from "Araraquara Cohort Study" according to their pre-pregnancy BMI. Fetal composition newborn assessed, respectively, by ultrasound anthropometry. The of in maternal blood, cord decidua placental villi tissues was evaluated...
Obesity is increasing in incidence worldwide, especially women, which can affect the outcome of pregnancy. During this period, viral infections represent a risk to mother, placental unit, and fetus. The Zika virus (ZIKV) outbreak Brazil has been cause congenital syndrome (CZS), with devastating consequences such as microcephaly newborns. Herein, we analyzed impact maternal overweight/obesity on antiviral factors’ expression tissue Zika-infected mothers. We accessed placentas from women...
To investigate associations of maternal and cord blood cytokine patterns with newborn size body composition.This cross-sectional study involved 70 pregnant women their healthy newborns selected from the "Araraquara Cohort Study". Newborn anthropometric measurements were recorded at birth. Body composition was evaluated by air displacement plethysmography. Maternal samples collected between 30 36 weeks gestation, umbilical immediately after placenta discharge. The concentrations cytokines...
Histoplasma capsulatum is a dimorphic fungus that develops yeast-like morphology in host’s tissue, responsible for the pulmonary disease histoplasmosis. The recent increase incidence of histoplasmosis immunocompromised patients highlights need understanding immunological controls fungal infections. Here, we describe our discovery role endogenous galectin-1 (Gal-1) immune pathophysiology experimental All infected wild-type (WT) mice survived while only 1/3 Lgals1 −/− genetically deficient...
The efficiency of isolation and purification the viral genome is a critical step to accuracy reliability RT-qPCR detect SARS-CoV-2. However, COVID-19 testing laboratories were overwhelmed by surge in diagnostic demand that affected supply chains especially low middle-income facilities.Thus, this study compares performance alternative methods extraction RNA samples patients diagnosed with COVID-19.Nasopharyngeal swabs submitted three in-house protocols commercial methods; was detected using...
Abstract Apoptotic cell clearance by professional and nonprofessional phagocytes in the process of efferocytosis is critical to preserve tissue homeostasis. Uptake apoptotic cells dendritic generates regulatory T induces immunologic tolerance against self-antigens. In contrast, ingestion infected promotes activation TLR4/MyD88-dependent bone marrow–derived (BMDCs) triggers Th17 differentiation. this study, we evaluated impact Streptococcus pneumoniae–infected BMDCs derived from C57BL/6 mice...
Objective: This integrative review aims to search and analyze scientific evidence on the relationship between obesity, immune function, depressive disorder. Methods: The present study is a descriptive of literature concerning keywords: depression, immunologic, inflammation, psychoneuroimmunology cytokines. inclusion criteria were: articles published in english; referring indexed PubMed database last 17 years. Results: A large amount indicates that function seems be compromised obesity has,...
Abstract A major cause of severe skin infections is methicillin-resistant Staphylococcus aureus (MRSA). Immunotherapeutic strategies are needed to treat infections. Neutrophils and macrophages control MRSA infection but undue inflammation causes injury. The bioactive eicosanoid leukotriene B4 a potent chemoattractant enhances phagocyte effector functions in naïve mice. However we have shown that diabetic mice produce chronic LTB4 which promotes susceptibility sepsis the role localized...