A5069013203- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Calcium signaling and nucleotide metabolism
- Trypanosoma species research and implications
- SARS-CoV-2 and COVID-19 Research
- COVID-19 and Mental Health
- Piperaceae Chemical and Biological Studies
- Pneumocystis jirovecii pneumonia detection and treatment
- Inflammatory Biomarkers in Disease Prognosis
- Mosquito-borne diseases and control
- Viral Infections and Immunology Research
- Cytomegalovirus and herpesvirus research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Viral Infections and Vectors
- Pregnancy and preeclampsia studies
- Research on Leishmaniasis Studies
- Tryptophan and brain disorders
Universidade de São Paulo
2020-2023
Coronavirus disease 2019 (COVID-19), caused by Severe Acute Respiratory Coronavirus-2 (SARS-CoV-2), has been declared a pandemic the World Health Organization in March 2020. COVID-19 cases develop severe acute respiratory syndrome, which can result multiple organ failure, sepsis, and death. The higher risk group incudes elderly, subjects with pre-existing chronic illnesses such as obesity, hypertension, diabetes. To date, no specific treatment or vaccine is available for COVID-19. Among many...
The formation of microthrombi in lung autopsies indicates the involvement NETs immunopathogenesis severe COVID-19. Therefore, supplements inhibiting NET formation, association with drugs fewer adverse effects, should be a relevant strategy to attenuate disease. Resveratrol (RESV) is natural polyphenol an important antiviral and antioxidant role. To modulate neutrophils from patients infected SARS-CoV-2, we evaluated vitro effect RESV on formation. Herein, investigated 190 hospitalized...
American trypanosomiasis, also named Chagas disease (CD), is an anthropozoonosis caused by the protozoan parasite Trypanosoma cruzi. The affects millions of people worldwide, leading yearly to approximately 50,000 deaths. COVID-19, generated SARS-CoV-2, can lead lymphopenia and death. We hereby describe first report two patients with CD COVID-19 coinfection, from hospitalization until patients'
The severe respiratory and systemic disease named coronavirus disease-2019 (COVID-19) is caused by the acute syndrome 2 (SARS-CoV-2). Currently, COVID-19 pandemic presents a huge social health challenge worldwide. Many different risk factors are associated with severity, such as arterial hypertension, diabetes mellitus, obesity, older age, other co-infections. Other diseases chronic obstructive pulmonary (COPD) smoking common comorbidities Previous investigations have identified among...
COVID-19, the infectious disease caused by SARS-CoV-2, has spread on a pandemic scale. The viral infection can evolve asymptomatically or generate severe symptoms, influenced presence of comorbidities. Lymphopenia based severity symptoms in patients affected with COVID-19 is frequent. However, profiles CD4+ and CD8+ T cells regarding cytotoxicity antiviral factor expression have not yet been completely elucidated acute SARS-CoV-2 infections. purpose this study was to evaluate phenotypic...
Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). COVID-19 has infected over 90 million people worldwide, therefore it considered a pandemic. SARS-CoV-2 infection can lead to pneumonia, distress (ARDS), septic shock, and/or organ failure. Individuals receiving heart transplantation (HT) may be at higher risk of adverse outcomes attributable due immunosuppressives, as well concomitant infections that also influence the prognoses....
Common clinical features of patients with Coronavirus disease-2019 (COVID-19) vary from fever, to acute severe respiratory distress syndrome. Several laboratory parameters are reported as indicators COVID-19 severity. We hereby describe the possible novel severity biomarkers for COVID-19, CD11b+CD33+HLA-DR-CD14+ cells and CD11b+CD33+HLA-DR-CD66b+ cells.
Obesity is increasing in incidence worldwide, especially women, which can affect the outcome of pregnancy. During this period, viral infections represent a risk to mother, placental unit, and fetus. The Zika virus (ZIKV) outbreak Brazil has been cause congenital syndrome (CZS), with devastating consequences such as microcephaly newborns. Herein, we analyzed impact maternal overweight/obesity on antiviral factors’ expression tissue Zika-infected mothers. We accessed placentas from women...
Coronavirus disease 2019 (COVID-19) caused millions of deaths worldwide. COVID-19’s clinical manifestations range from no symptoms to a severe acute respiratory syndrome, which can result in multiple organ failure, sepsis, and death. Severe COVID-19 patients develop pulmonary extrapulmonary infections, with hypercoagulable state. Several inflammatory or coagulatory biomarkers are currently used predictive values for severity prognosis. In this manuscript, we investigate if combination could...