A5015067871- Epigenetics and DNA Methylation
- Adipose Tissue and Metabolism
- Dietary Effects on Health
- Diet and metabolism studies
- Bariatric Surgery and Outcomes
- Muscle metabolism and nutrition
- Cardiovascular Disease and Adiposity
- Tea Polyphenols and Effects
- Telomeres, Telomerase, and Senescence
- Nutrition and Health in Aging
- Eating Disorders and Behaviors
- Nutrition, Genetics, and Disease
- Obesity, Physical Activity, Diet
- Birth, Development, and Health
- Adipokines, Inflammation, and Metabolic Diseases
- Cancer-related molecular mechanisms research
- Physical Activity and Health
- Trace Elements in Health
- Histone Deacetylase Inhibitors Research
- Selenium in Biological Systems
- Digestive system and related health
- Obesity and Health Practices
- Gestational Diabetes Research and Management
- Climate Change and Health Impacts
- Heart Rate Variability and Autonomic Control
Universidade de São Paulo
2016-2024
Clinics Hospital of Ribeirão Preto
2017-2024
University Medical Center Groningen
2024
University of Groningen
2024
Universidade de Ribeirão Preto
2014-2022
Weatherford College
2022
British Neuroscience Association
2018
This is a longitudinal single-arm clinical trial aimed to investigate whether exercise training would modify the whole blood methylation profile in healthy women. A total of 45 subjects were engaged an protocol during 14-wk follow up, consisting aerobic cardiorespiratory and muscle strength exercises. Subjects evaluated at baseline (PRE), after 7 wk (POST 7), 14 14). Functional primary outcomes included anthropometric, pressure, biochemical measurements, physical tests, global health...
Combined (CT) and multicomponent training (MT) presents several benefits for aging individuals. However, the literature does not provide evidence on which of two physical models can better enhance improvements in capacity health parameters middle-aged older women.The aim this study was to compare effects MT CT capacity, cognitive, behavioral, psychosocial assessment, biochemical profile physically inactive women aged between 50 70 years.Participants were randomized into groups: (32 women,...
Abstract Background Telomere length is inversely associated with the senescence and aging process. Parallelly, obesity can promote telomere shortening. Evidence suggests that physical activity may elongation. Objective This study’s objective to evaluate effects of combined exercise training on in obese women. Design Methods Twenty pre-menopausal women (BMI 30–40 kg/m 2 , 20–40 years) submitted (strength aerobic exercises), but only 13 finished protocol. Each session lasted 55 min/day, three...
Background Pre-diabetes precedes Diabetes Mellitus (DM) disease and is a critical period for hyperglycemia treatment, especially menopausal women, considering all metabolic alterations due to hormonal changes. Recently, the literature has demonstrated role of physical exercise in epigenetic reprogramming modulate gene expression patterns conditions, such as hyperglycemia, prevent DM development. In present study, we hypothesized that training could modify women with poor glycemic control....
Nutriepigenetic markers are predictive responses associated with changes in "surrounding" environmental conditions of humans, which may influence metabolic diseases. Although rich calories, Western diets could be linked the deficiency micronutrients, resulting downstream epigenetic and effects consequently obesity. Zinc (Zn) is an essential nutrient distinct biological roles human health. Despite importance Zn processes, little known about relationship between epigenetic. Thus, present study...
Background/Objective Uncoupling proteins (UCPs) are located in the inner membrane of mitochondria. These participate thermogenesis and energy expenditure. This study aimed to evaluate how UCP1 UCP3 expression influences substrate oxidation elicits possible changes body composition patients submitted bariatric surgery. Subjects/Methods is a longitudinal comprising 13 women with obesity grade III that underwent surgery 10 healthy weight individuals (control group). Body was assessed by...
Purpose: The acceleration of epigenetic age is a predictor mortality and contributes to the increase in chronic diseases. Adherence healthy lifestyle strategy reduce age. present study aimed determine whether eight weeks combined (aerobic strength) training (CT) can influence women between 50 70 years old differences sites methylated regions. Methods: Eighteen (AARLow: lower residual, n = 10; AARHigh: higher 8) participated exercise program (60 minutes, 3× week) for weeks. DNA was extracted...
Exercise training emerges as a key strategy in lifestyle modification, capable of reducing the risk developing Alzheimer's disease (AD) due to factors such age, family history, genetics and low level education associated with AD. We aim analyze effect 14-week combined exercise (CT) on methylation genes AD non-alzheimer's women. CT sessions lasted 60 min, occurring three times week for 14 weeks. Forty non-Alzheimer's women aged 50 70 years (60.7 ± 4.1 years) mean height 1.6 0.1 m, weight...
Highlights•Body Mass index-correlated genes suggest the impact of immunometabolism in severe COVID-19.•Expression 15 metabolism and immune-related was exclusively induced lungs obese COVID-19 patients.•Metabolic changes antiviral immunity may increase inflammation patients.SummaryBackground & aimsObesity is associated with low grade systemic insulin resistance. Although metabolic immunological contribute to increased risk for mortality obese, little known about obesity patients...
Abstract Background and study aims Endoscopic procedure using argon plasma coagulation (APC) promotes a progressive reduction in gastrojejunal anastomosis diameter. The present aimed to evaluate the efficacy of APC patients with weight regain postoperative periods gastric bypass. Patients methods This was randomized controlled trial conducted 66 who were randomly assigned selected (using lottery method) divided into two groups: group (SG), 38 (APC treatment); control (CG), 28 (only endoscopy...
This study aims (i) to verify expression of the UCPs, PLIN1, PPARG2, and ADRB3 genes in abdominal subcutaneous adipose tissue obese women at baseline after 8 weeks supplementation with decaffeinated green tea extract, (ii) associate findings clinical parameters. is a longitudinal during which 11 obesity grade III were submitted 450 mg (-)-epigallocatechin gallate (EGCG) (intervention group); control group consisted 10 eutrophic women. Anthropometric parameters [weight, height, body mass...
Introduction: obesity is associated with high levels of oxidative stress (OS) and inflammation. There a lot evidence that some polyphenols, such as green tea, have positive impact on the OS state consecutively, Objectives: purposes this study were: a) evaluate biomarkers in both obese normal weight women; b) if tea supplementation has an inflammatory cytokine women. Methods: we evaluated (body mass index [BMI] ≥ 40 kg/m²) (BMI between 18.5 24.9 Blood samples were used to access...
Obesity is directly connected to lifestyle and has been associated with DNA methylation changes that may cause alterations in the adipogenesis lipid storage processes contributing development of disease. We demonstrate a complete protocol from selection epigenetic data analysis patients without obesity. All steps were tested validated pilot study. 32 women participated study, which 15 individuals classified obesity according Body Mass Index (BMI) (45.1 ± 5.4 kg/m2); 17 BMI (22.6 1.8 kg/m2)....
Introduction There is an emerging body of evidence that vitamin C consumption can modulate microbiota abundance and also impact DNA methylation in the host, this could be a link between diet, microbiota, immune response. The objective study was to evaluate common CpG sites associated with both phyla abundance. Methods Six healthy women participated cohort study. They were divided into two groups, according amount they ingested. Ingestion evaluated using 24-h recall method. Illumina 450 k...
Obesity, a multifactorial disorder, has been associated with alterations in metal metabolismand epigenetic modifications. This pilot case–control study aimed to investigate serum cobalt concentrations and DNA methylation patterns women obesity. Serum levels were measured using inductively coupled plasma mass spectrometry (ICP-MS), revealing significantly higher participants normal weight than Additionally, analysis identified differentially methylated positions (DMPs) exposure, DMPs between...
The mechanisms by which the ageing process is associated to an unhealthy lifestyle and how they play essential role in aetiology of systemic arterial hypertension have not yet been completely elucidated. Our objective investigate influence NOS3 polymorphisms [-786T > C (Glu298Asp)] on systolic blood pressure (SBP) diastolic (DBP) response, differentially methylated regions (DMRs), physical fitness adult older women after a 14-week combined training intervention. was carried out for 14 weeks,...