A5018837648- Epigenetics and DNA Methylation
- Melanoma and MAPK Pathways
- Histone Deacetylase Inhibitors Research
- Redox biology and oxidative stress
- melanin and skin pigmentation
- bioluminescence and chemiluminescence research
- Computational Drug Discovery Methods
- Vitamin C and Antioxidants Research
- Birth, Development, and Health
- Climate Change and Health Impacts
- Physical Activity and Health
- Spatial and Panel Data Analysis
- Cervical Cancer and HPV Research
- demographic modeling and climate adaptation
- Research on Leishmaniasis Studies
- Cutaneous Melanoma Detection and Management
- Statistical Methods and Bayesian Inference
- Economic and Environmental Valuation
- Digestive system and related health
- Microbial metabolism and enzyme function
- Vitamin D Research Studies
- Fibroblast Growth Factor Research
- Healthcare and Environmental Waste Management
- Reproductive tract infections research
- Genetics and Neurodevelopmental Disorders
Universidade de São Paulo
2021-2024
Universidade Estadual de Maringá
2021-2022
Microenvironment and transcriptional plasticity generate subpopulations within the tumor, use of BRAF inhibitors (BRAFis) contributes to rise selection resistant clones. We stochastically isolated (C1, C2, C3) from naïve melanoma found that clones demonstrated distinct morphology, phenotypic, functional profiles: C1 was less proliferative, more migratory invasive, sensitive BRAFis, dependent on OXPHOS, oxidative stress, pigmented; C2 C3 pigmented. Hydrogen peroxide plays a central role in...
Background Pre-diabetes precedes Diabetes Mellitus (DM) disease and is a critical period for hyperglycemia treatment, especially menopausal women, considering all metabolic alterations due to hormonal changes. Recently, the literature has demonstrated role of physical exercise in epigenetic reprogramming modulate gene expression patterns conditions, such as hyperglycemia, prevent DM development. In present study, we hypothesized that training could modify women with poor glycemic control....
The second most common mutation in melanoma occurs NRAS oncogene, being a more aggressive disease that has no effective approved treatment. Besides, cellular plasticity limits better outcomes of the advanced and therapy-resistant patients. Peroxiredoxins (PRDXs) control processes through direct hydrogen peroxide oxidation or by redox-relaying processes. Here, we demonstrated PRDX2 could act as modulator multiple EMT markers NRAS-mutated melanomas. knockdown lead to phenotypic changes towards...
Purpose: The acceleration of epigenetic age is a predictor mortality and contributes to the increase in chronic diseases. Adherence healthy lifestyle strategy reduce age. present study aimed determine whether eight weeks combined (aerobic strength) training (CT) can influence women between 50 70 years old differences sites methylated regions. Methods: Eighteen (AARLow: lower residual, n = 10; AARHigh: higher 8) participated exercise program (60 minutes, 3× week) for weeks. DNA was extracted...
Exercise training emerges as a key strategy in lifestyle modification, capable of reducing the risk developing Alzheimer's disease (AD) due to factors such age, family history, genetics and low level education associated with AD. We aim analyze effect 14-week combined exercise (CT) on methylation genes AD non-alzheimer's women. CT sessions lasted 60 min, occurring three times week for 14 weeks. Forty non-Alzheimer's women aged 50 70 years (60.7 ± 4.1 years) mean height 1.6 0.1 m, weight...
Highlights•Body Mass index-correlated genes suggest the impact of immunometabolism in severe COVID-19.•Expression 15 metabolism and immune-related was exclusively induced lungs obese COVID-19 patients.•Metabolic changes antiviral immunity may increase inflammation patients.SummaryBackground & aimsObesity is associated with low grade systemic insulin resistance. Although metabolic immunological contribute to increased risk for mortality obese, little known about obesity patients...
Obesity is directly connected to lifestyle and has been associated with DNA methylation changes that may cause alterations in the adipogenesis lipid storage processes contributing development of disease. We demonstrate a complete protocol from selection epigenetic data analysis patients without obesity. All steps were tested validated pilot study. 32 women participated study, which 15 individuals classified obesity according Body Mass Index (BMI) (45.1 ± 5.4 kg/m2); 17 BMI (22.6 1.8 kg/m2)....
Introduction There is an emerging body of evidence that vitamin C consumption can modulate microbiota abundance and also impact DNA methylation in the host, this could be a link between diet, microbiota, immune response. The objective study was to evaluate common CpG sites associated with both phyla abundance. Methods Six healthy women participated cohort study. They were divided into two groups, according amount they ingested. Ingestion evaluated using 24-h recall method. Illumina 450 k...
Objective: The present report investigated the rates of coinfections between high-rik human papillomavirus (hrHPV) and most important mycoplasmas including Mycoplasma hominis, M. genitalium, Ureaplasma urealyticum U. parvum in cervical samples asymptomatic brazilian population. Methods: Were included a total 283 women aged 25–64 years screened by Papanicolaou smears for determining abnormalities, single-target polymerase chain reaction (PCR) real-time PCR (rt-PCR) hrHPV mycoplasmas,...
Journal Article THE HYDROLYSIS OF PREGNANEDIOL GLUCURONIDE BY GLUCURONIDASE PREPARATIONS Get access Endocrinology, Volume 54, Issue 3, 1 March 1954, Pages 353–355, https://doi.org/10.1210/endo-54-3-353 Published: 01 1954 history Received: 18 August 1953
Abstract The impact of advanced glycation end products (AGEs) accumulation is associated with the development and exacerbation many degenerative processes disorders, including aging cancer. AGEs in skin leads to stiffness loss elasticity by building up connective tissue during process. This process has implications extracellular matrix, affecting adhesion, migration, invasiveness potential melanoma cells. Furthermore, tumor correlated mechanical stiffness, contributing high metastatic...
The endogenous estradiol derivative 2-Methoxyestradiol (2-ME) has shown good and wide anticancer activity but suffers from poor oral bioavailability extensive metabolic conjugation. However, its sulfamoylated derivative, 2-methoxyestradiol-3,17-O,O-bis-sulfamate (STX140), superior potential as a therapeutic agent, acts by disrupting microtubule polymerization, leading to cell cycle arrest apoptosis in cancer cells possesses much better pharmaceutical properties. This study investigated the...
The impact evaluation of exogenous policies over time is great importance in several areas. Unfortunately, an adequate time-series analysis has not always been taken into account the literature, mainly health problems. When regression models are used known interrupted approach, required error assumptions general neglected. Specifically, usual linear segmented (lmseg) when errors have nonconstant variance and serial correlation. To instigate correct use intervention analysis, we present a...
Objectives: To investigate the hospital morbidity related to leishmaniasis in a state of Southern Brazil and analyse management financial resources regarding expenses. Methods: This is cross-sectional study. The cases admissions due recorded Paraná between 2008-2018 were obtained by consulting IT Department Unified Health System (DATASUS), Brazil. profile hospitalized patients, character medical care expenses with service investigated. data statistically analysed on Epi Info™ version 3.5.4....
Obesity is directly connected to lifestyle and has been associated with DNA methylation changes that may cause alterations in the adipogenesis lipid storage processes contributing development of disease. We demonstrate a complete protocol from selection epigenetic data analysis patients without obesity. All steps were tested validated pilot study. 32 women participated study, which 15 individuals classified obesity according Body Mass Index (BMI) (45.1 ± 5.4 kg/m2); 17 BMI (22.6 1.8 kg/m2)....