A5013370742- Research on Leishmaniasis Studies
- Trypanosoma species research and implications
- Insect Pest Control Strategies
- Insect and Pesticide Research
- Parasites and Host Interactions
- Dermatological diseases and infestations
- Photodynamic Therapy Research Studies
- Synthesis and biological activity
- Eosinophilic Disorders and Syndromes
- Laser Applications in Dentistry and Medicine
- Toxin Mechanisms and Immunotoxins
- Synthesis and Biological Evaluation
- Insect Resistance and Genetics
- Phytochemistry and Bioactivity Studies
- Phytochemical compounds biological activities
- Exercise and Physiological Responses
- Hibiscus Plant Research Studies
- Toxoplasma gondii Research Studies
- Bioactive Compounds and Antitumor Agents
- Leptospirosis research and findings
- T-cell and Retrovirus Studies
- Contact Dermatitis and Allergies
- Phytochemistry and Bioactive Compounds
- Wound Healing and Treatments
- Women's cancer prevention and management
Universidade Estadual de Maringá
2013-2022
The aim of this study was to investigate the effectiveness Photodynamic Therapy (PDT) using Methylene Blue (MB) as photosensitizing compound and a Light-Emitting Diode (LED) in American cutaneous leishmaniasis (ACL). Hamsters were experimentally infected with Leishmania (Leishmania) amazonensis. After development lesions footpad, animals treated MB three times week for 3 months. Ten minutes after each application MB, irradiated LED 1 h. evaluated weekly by measurement hamster footpad...
The Montenegro skin test (MST) has good clinical applicability and low cost for the diagnosis of American tegumentary leishmaniasis (ATL). However, no studies have validated reference value (5mm) typically used to discriminate positive negative results. We investigated MST results evaluated its performance using different cut-off points.The laboratory tests 4,256 patients with suspected ATL were analyzed, 1,182 individuals found fulfill established criteria. Two groups formed. cutaneous...
Cutaneous leishmaniasis (CL) can occur in skin and mucosa, causing disfiguring lesions. The laboratory diagnosis of CL involves immunological methods optical detection the parasite, al which have limitations. There is a need for more effective diagnostic wil allow treatment to be initiated promptly order help prevent development severe forms mucosal disease, estimate prognosis infection. polymerase chain reaction (PCR) has been widely used diagnose CL, because its higher sensitivity. This...
The herbaceous shrub Tetradenia riparia has been traditionally used to treat inflammatory and infectious diseases. Recently, a study showed that T. essential oil (TrEO) obtained in summer antileishmanial effects, although these results could be influenced by seasonal variation. This evaluated the activity of TrEO different seasons against Leishmania (Leishmania) amazonensis, vitro vivo. compounds were analysed gas chromatography-mass spectrometry; terpenoids present oxygenated sesquiterpenes...
The topical and intradermal photodynamic therapy (PDT) effect of methylene blue (MB) using light-emitting diode (LED) as light source (MB/LED-PDT) in the treatment lesions American cutaneous leishmaniasis (ACL) caused by Leishmania braziliensis hamsters were investigated.Hamsters infected footpad with 4×10(7) promastigotes L. divided 4 groups: Control group was not treated, AmB treated amphotericin B, MB-Id received MB at edge lesion MB-Tp topic. After MB, animals illuminated red LEDs 655 nm...
Summary Cutaneous leishmaniasis usually presents therapeutic resistance to antimonials, and the existing therapies for have many adverse effects toxicity. Natural products may be regarded as possible candidates alternative treatment. The plant Tetradenia riparia has shown promise treatment of infectious diseases in folk medicine. We evaluated antileishmanial activity an essential oil from T. (Tr EO ) modulatory Tr on cytokine modulation by peritoneal fluid cells that were infected with L....
SUMMARY Leishmania infantum causes visceral leishmaniasis (VL) in the New World. The diagnosis of VL is confirmed by parasitological and serological tests, which are not always sensitive or specific. Our aim was to design new primers perform a Polymerase Chain Reaction (PCR) for detecting L. infantum. Sequences minicircle kinetoplast DNA (kDNA) were obtained from GenBank, FLC2/RLC2 designed. Samples infantum, amazonensis, braziliensis, guyanensis, naiffi, lainsoni, panamensis, major...
Introduction: The treatment of cutaneous leishmaniasis (CL) is based primarily on the use pentavalent antimonials, which may lead to many side effects limiting their use. Photodynamic therapy (PDT) an alternative for CL, and some xanthene dyes have potential in PDT. Methods: xanthenes rose bengal B (RB) its derivatives methyl ester (RBMET), butyl (RBBUT) were analyzed leishmanicidal activity against promastigotes intracellular amastigotes Leishmania amazonensis. Cytotoxicity was assessed...
This case report alerts to the existence of atypical forms cutaneous leishmaniasis (CL). A woman with nodular lesions over a neck papules and pustules located deep in hypodermis that formed plaques subcutaneous induration satellite was confirmed have CL. After confirmation, patient treated remission lesions, scarring thickening skin.
This study evaluated the reactivity of membrane antigens Leishmania (Viannia) braziliensis for diagnosis ACL by enzyme immunoassay (EIA). Promastigotes L. (V.) were grown in medium 199 and lysed a sonicator. Sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) Western blotting showed that specific proteins (apparent molecular weights 36 kDa 48-56 kDa) recognized sera from patients. These eluted SDS-PAGE tested EIA-IgG with patients, healthy individuals, patients...
The clinical manifestations and prognosis of cutaneous leishmaniasis (CL) can be influenced by the immune response patient species parasite. A case atypical presentation CL, with development non-characteristic lesions, poor to therapy, a long time resolution is reported. Confirmatory laboratory tests included parasite detection, indirect immunofluorescence, Montenegro skin test, polymerase chain reaction, identification multilocus enzyme electrophoresis. was identified as...
Leishmaniasis is a group of diseases that presents various clinical manifestations. Many studies have shown the parasite plays an important role in manifestations and prognosis this disease. The cutaneous mucosal forms American tegumentary leishmaniasis (ATL) are associated with Leishmania (Viannia) braziliensis, which exhibits intraspecific genetic polymorphisms present study focused on four different L. braziliensis strains were isolated from patients distinct Glucantime(®) treatment...