A5081912497- Dermatology and Skin Diseases
- Allergic Rhinitis and Sensitization
- Contact Dermatitis and Allergies
- Immunotherapy and Immune Responses
- T-cell and Retrovirus Studies
- IL-33, ST2, and ILC Pathways
- Oral Health Pathology and Treatment
- Inflammasome and immune disorders
- Immune Cell Function and Interaction
- Immune Response and Inflammation
- Fungal Infections and Studies
- Cutaneous Melanoma Detection and Management
- Antibiotic Resistance in Bacteria
- Nonmelanoma Skin Cancer Studies
- Mosquito-borne diseases and control
- Pregnancy and preeclampsia studies
- Neutropenia and Cancer Infections
- Hippo pathway signaling and YAP/TAZ
- Autoimmune and Inflammatory Disorders Research
- T-cell and B-cell Immunology
- Nail Diseases and Treatments
- COVID-19 and healthcare impacts
- Viral Infectious Diseases and Gene Expression in Insects
- S100 Proteins and Annexins
- Psoriasis: Treatment and Pathogenesis
Universidade de São Paulo
2009-2025
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
2018-2022
Hospital de Santo António
2021
Centro Hospitalar do Porto
2021
Tata Memorial Hospital
2014
University of Chile
2013
Hospital del Trabajador
2013
Abstract Background Atopic dermatitis (AD) in adults and profile of skin barrier proteins inflammatory cytokines. Objective Evaluation the expression such as filaggrin, claudins 1 4 circulating cytokines (Th1/Th2/Th17) with AD. Methods Thirty‐three adult patients AD diagnosed according to Hanifin & Rajkacriteria, 25 healthy controls were enrolled study. severity was measured by Eczema Area Severity Index (EASI). Laboratory assays included immunohistochemistry analysis proteins,...
BACKGROUND: Blood stream infections (BSI) are among the most common causes of preventable deaths in children with cancer a developing country. Knowledge its etiology as well antibiotic sensitivity is essential not only for planning antimicrobial policy, but also larger infection prevention and control measures. AIMS: To describe BSI pediatric oncology unit at tertiary center. MATERIALS AND METHODS: All samples representative sent from during period January to December, 2013 were included...
BACKGROUND: Infection or colonization with multidrug-resistant organisms (MDRO) is associated high mortality and morbidity. Knowledge of MDRO may help in planning empirical antibiotic approach neutropenic patients, which known to improve patient outcomes. While routine cultures are positive direct therapy only up 15% surveillance more than 90% cancer patients. AIMS: To assess the rate carrier status at presentation conversion during treatment. MATERIALS AND METHODS: Rectal swabs all...
Atopic dermatitis (AD) is a chronic inflammatory immune-mediated skin disease characterized by colonization Staphylococcus aureus. Interleukin (IL)-22, in cooperation with IL-17, triggers antimicrobial peptide elaboration and enhances certain immunological responses. In AD, IL-22 related to epidermal hyperplasia, keratinocyte apoptosis, inhibition of (AMP) production. We aimed evaluate the impact staphylococcal enterotoxins on Tc22/Th22 induction peripheral blood AD patients CD4
Abstract Atopic dermatitis (AD) is a complex, multifactorial skin disease, characterized by pruritus and predominant Th2 inflammation. Innate immune cells may play role in AD development are composed of granulocytes, macrophages, innate-like T cells, innate lymphoid cells. This study investigates the phenotypic functional profile circulating CLA + natural killer (NK) its skin-homing to NK infiltrated adults’ with AD. We selected 44 patients 27 non-AD volunteers for study. The results showed...
Lichen planus (LP) is a chronic inflammatory mucocutaneous disease. The status of LP may be related to S100A8 (myeloid-related protein 8; MRP8) activation cytotoxic cells. aims this study were evaluate expression in skin lesions and the vitro effects on CD8+ T cells natural killer (NK) LP. Increased levels S100A8/S100A9 detected as well sera subjects with induced an increased response by peripheral blood CD8+CD107a+ NK CD56bright patients interleukin (IL)-1β, tumour necrosis factor (TNF)...
Coagulation disorders contribute to the development of livedoid vasculopathy (LV). Elevated plasma levels lipoprotein(a) [Lp(a)] are an independent risk factor for cardiovascular disease and associated with hypercoagulable states. Increased serum Lp(a) have been reported in patients LV may important role pathogenesis LV.To investigate expression skin lesions circulating LV.Skin biopsy samples from 38 (27 women 11 men) active diagnosed as 9 normal (5 4 control without were evaluated by...
Background: CD8+ T cells and natural killer (NK) are involved in the immune response against some pathogens. For this purpose, we investigated situ paracoccidioidomycosis (PCM) addressing participation of NK cells, perforin granzyme B expression. Methods: Sixty biopsies PCM skin mucosa were classified according to presence compact granulomas (G1), poorly organized (G2) both kinds same lesion (G3). showed by immunohistochemistry. Results: increased over cutaneous G1 G2 lesions. There was no...
Acral lentiginous melanoma (ALM) is the most common type of in people with darker skin phototypes. There some evidence that aetiology, pathogenesis, risk factors and natural history ALM differ from those superficial spreading (SSM). behaves more aggressively than SSM, but biological explanation for these differences remains unknown. The presence one subtype macrophages, termed M2-macrophage (M2-M), has been found to be related local progression, metastasis poor prognosis several neoplasms....
Erythroderma is a clinical skin syndrome shared by patients with cutaneous disorders of distinct aetiologies as result the combined actions chemokines, adhesion molecules, and cytokines, such vascular endothelial growth factor (VEGF).To evaluate profile serum levels VEGF soluble receptor 1 (sVEGFR-1) in pemphigus foliaceus (PF) erythroderma.We conducted retrospective study, which included (i) chart review all PF from Autoimmune Blistering Clinic, University Sao Paulo, Brazil, January 1991 to...
Methylisothiazolinone (MI) and Methylchloroisothiazolinone (MCI) are among the most common skin sensitizers, yet immunological events that occur during MCI/MI allergic contact dermatitis (ACD) still poorly understood.To analyse dendrocytes, macrophage subtypes T cells in elicitation phase of ACD.Thirteen patients with positive patch test reactions to (ACD group) 11 individuals negative results were selected. Skin biopsies only performed at 48 hours testing. Immunohistochemistry was conducted...
Innate immunity is one of the main protection mechanisms against viral infections, but how this system works at maternal-fetal interface, especially during HIV infection, still poorly known. In work, we investigated relationship between pregnancy and innate associated to by evaluating expression DAMPs, inflammasome components type I/III IFNs in placenta serum samples from HIV-infected mothers exposed newborns. Our results showed that most these factors, including HMGB1, IL-1 IFN, were...
Atopic dermatitis (AD) is an itchy, chronic and inflammatory skin condition, with dysfunctional immune response barrier defects. Reduction of filaggrin (FLG) tight junctions (TJ) proteins, such as claudin-1 (CLDN-1), expression in cutaneous epithelial remarkable AD pathogenesis. Ocular involvement occurs approximately 40% patients leading to changes the structure conjunctiva.We aimed evaluate FLG CLDN-1 ocular surface adults AD, analysing bulbar conjunctival cells collected by a novel...
Obesity is increasing in incidence worldwide, especially women, which can affect the outcome of pregnancy. During this period, viral infections represent a risk to mother, placental unit, and fetus. The Zika virus (ZIKV) outbreak Brazil has been cause congenital syndrome (CZS), with devastating consequences such as microcephaly newborns. Herein, we analyzed impact maternal overweight/obesity on antiviral factors’ expression tissue Zika-infected mothers. We accessed placentas from women...
Abstract Background Methylchloroisothiazolinone (MCI) and methylisothiazolinone (MI) are the cause of an increasing number contact allergies. Understanding mechanisms by which MCI/MI induces proinflammatory regulatory factors production is necessary to understand outcome allergic dermatitis (ACD). Objectives To evaluate dysfunction cytokines in positive patch test at transcriptional protein expression levels. Moreover, analyse induced MI peripheral blood mononuclear cells (PBMCs). Materials...
Abstract Background Renal transplant recipients (RTRs) are at increased risk of developing skin cancer; however, the role immunosuppression is not yet fully understood. In this study, we evaluated immunohistochemical changes in RTRs under three different regimens: mTOR inhibitors (mTORi), sirolimus or everolimus, mycophenolic acid (MPA) precursors such as mycophenolate sodium mofetil, azathioprine (AZA). Methods We biopsies sun‐exposed and sun‐protected for quantification B lymphocytes (CD20...
Lichen planus (LP) is an inflammatory skin disease with unknown aetiology. Activation by pathogen‐associated molecular patterns or environmental stimuli may activate some components of inflammasomes that contribute to the process in LP lesions. To characterize lesions and peripheral blood mononuclear cells (PBMCs) patients under Toll‐like receptor (TLR) activation. In total, 15 14 healthy controls (HCs) were enrolled study. Inflammasome expression was evaluated real‐time PCR...
Epidermodysplasia verruciformis (EV) is a genodermatosis related to human beta-papillomavirus (beta-HPV), with high risk of cutaneous squamous cell carcinoma (cSCC). Claudins are transmembrane proteins expressed in epithelia and may be altered during carcinogenesis. For better understanding the role beta-HPV carcinogenesis, this claudin expression study was conducted on lesions patients without EV. In study, claudins-1, -2, -3, -4, -5, -7 -11 expressions were analyzed by applying...
ResumenEl cuero cabelludo es la barrera más externa y importante del cráneo cerebro.Si bien las quemaduras de esta zona son raras, cuando se producen suelen estar causadas por alta tensión eléctrica, fuego, líquidos hirvientes u otras fuentes calor.El objetivo este trabajo presentar una serie casos tratadas en los últimos 10 años el Hospital Trabajador Santiago (Chile).Se trata un estudio descriptivo retrospectivo que analizó información demográfica terapéutica pacientes requirieron...