A5045241708- Air Quality and Health Impacts
- Retinal Development and Disorders
- Retinal Diseases and Treatments
- Allergic Rhinitis and Sensitization
- Vehicle emissions and performance
- Ocular Surface and Contact Lens
- Retinal and Macular Surgery
- Indoor Air Quality and Microbial Exposure
- Skin Protection and Aging
- Energy and Environment Impacts
- Retinopathy of Prematurity Studies
- Climate Change and Health Impacts
- Animal Disease Management and Epidemiology
- T-cell and Retrovirus Studies
- Genetics and Physical Performance
- Occupational Health and Performance
- Air Quality Monitoring and Forecasting
- Carcinogens and Genotoxicity Assessment
- Sports Performance and Training
- Noise Effects and Management
- Glycosylation and Glycoproteins Research
- Systemic Sclerosis and Related Diseases
- Cardiovascular Effects of Exercise
- Inflammatory Myopathies and Dermatomyositis
- Glaucoma and retinal disorders
Universidade de São Paulo
2016-2025
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
2007-2022
University of Miyazaki
2012-2020
Faculty (United Kingdom)
2015
National Council for Scientific and Technological Development
2012
Ophthalmology Associates (United States)
2012
To evaluate the effect of high levels environmental air pollution on tear osmolarity and its possible correlation with clinical signs symptoms.This was a panel study involving 71 taxi drivers traffic controllers from São Paulo, Brazil. Mean individual 24-hour exposure to nitrogen dioxide (NO2) particulate matter smaller than 2.5 μm (PM2.5) were assessed 4 different occasions. On first third visits, subjects submitted evaluations including administration Ocular Surface Disease Index...
Ocular mucosa is exposed constantly to the external environment, and chronic exposure air pollution may affect ocular surface.We assessed effect of on surface by combining determinations individual conjunctival impression cytology.A panel study was conducted with 29 volunteers recruited in two locations different levels: São Paulo (n = 13) Divinolândia 16). We mean levels nitrogen dioxide (NO2) for 7 days, using a passive sampler. Impression cytology samples were obtained from inferior...
To evaluate the effect of diesel exhaust particles (DEP) on viability, proliferation, apoptosis, secretion cytokines (IL-6, IL-8, and TNF-α), mucin gene transcription (MUC1, MUC5AC, MUC16) in human epithelial cells cornea (HCLE) conjunctiva (IOBA-NHC).HCLE IOBA-NHC were incubated with DEP (10-500 μg/mL) for 24 hours. Cell proliferation was evaluated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. Apoptotic measured an annexin V-FITC propidium iodide kit flow cytometry....
Background: Aerobic exercise is recommended to improve health. However, the increased ventilation might increase doses of inhaled air pollutants, negating health benefits in highly polluted areas. Our objective was estimate dose pollutants during two simulated sessions at cleanest and dirtiest cities reported by World Health Organization (WHO) considering quality. Methods: Minute data were extracted from laboratory-based 116 incremental running tests used calculate total a hypothetical...
Abstract Diesel exhaust particles (DEP) are known to generate reactive oxygen species in the respiratory system, triggering cells activate antioxidant defence mechanisms, such as Keap1-Nrf2 signalling and autophagy. The aim of this study was investigate relationship between autophagy pathways after DEP exposure. BEAS-2B were transfected with silencing RNA (siRNA) specific Nrf2 exposed DEP. relative levels mRNA for Nrf2, NQO1, HO-1, LC3B, p62 Atg5 determined using RT-PCR, while LCB3, protein...
Background Air pollution is one of the most environmental health concerns in world and has serious impact on human health, particularly mucous membranes respiratory tract eyes. However, ocular hazardous effects to air pollutants are scarcely found literature. Design Panel study evaluate effect different levels ambient lacrimal film cytokine outdoor workers from a large metropolitan area. Methods Thirty healthy male workers, among them nineteen professionals who work streets (taxi drivers...
Abstract Exposure to air pollution has been a significant challenge in large cities as São Paulo, Brazil, particularly for individuals exercising outdoors. The increasing on ventilation (VE) during physical effort can lead greater pollutant inhalation. Our goal the present study evaluated whether exposure affects venous blood gases and if it an impact performance 50‐km cycling time trial (TT). Ten male cyclists performed TT environmental chamber under TRAP filtered conditions. Venous samples...
The aim of the present study was to analyze effects traffic-related air pollution (TRAP) on markers inflammatory, neuroplasticity, and endurance performance-related parameters in recreationally trained cyclists who were adapted TRAP during a 50-km cycling time trial (50-km TT). Ten male performed TT inside an environmental chamber located downtown Sao Paulo (Brazil), under or filtered conditions. Blood samples obtained before after measure inflammatory [interleukin-6 (IL-6), C-reactive...
Changes in the proteoglycans glypican and syndecan-4 have been reported several pathological conditions, but little is known about their expression heart during diabetes. The aim of this study was to investigate vivo function changes alterations mRNA protein levels glypican-1 cardiac skeletal muscles streptozotocin (STZ)-induced Diabetes induced male Wistar rats by STZ administration. were assigned one following groups: control (sham injection), after 24 hours, 10 days, or 30 days...
The purpose of this study was to verify the association between ACTN3 polymorphism and physiological parameters related endurance performance. A total 150 healthy male volunteers performed a maximal incremental running test determine speeds corresponding ventilatory threshold (VT) respiratory compensation point (RCP). Participants were genotyped divided into terciles based on analysed variables. Genotype frequencies compared through χ2 lower higher terciles, with lowest or highest values...
Covering long distances was an important trait to human evolution and continues be highlighted for health athletic status. This ability is benefitted by a low cost of locomotion (CoL), meaning that the individuals who are able expend less energy would cover longer distances. The CoL has been shown influenced distinct even 'opposite' factors, such as physiological muscular characteristics, which genetically inherited. In this way, DNA alterations could determinants characteristics associated...
Vascular endothelial growth factor (VEGF) is an important signal protein in vertebrate nervous development, promoting neurogenesis, neuronal patterning, and glial cell growth. Bevacizumab, anti-VEGF agent, has been extensively used for controlling pathological retinal neovascularization adult newborn patients, although its effect on the developing retina remains largely unknown. The purpose of this study was to investigate bevacizumab death, proliferation, differentiation rat retina.Retinal...
The COL5A1 rs12722 polymorphism is considered to be a novel genetic marker for endurance running performance. It has been postulated that may influence the elasticity of tendons and energetic cost running. To date, there are no experimental data in literature supporting relationship between range motion, economy, gene polymorphism. Therefore, main purpose current study was analyze COL5A1rs12722 on economy motion. One hundred fifty (n = 150) physically active young men performed following...
Background and Objective: Cyclosporin A‐induced gingival overgrowth comprises a variety of signaling pathways (including growth factors proteoglycans) that are still not completely understood. In the present study, was investigated in transplant patients receiving cyclosporin A (cyclosporin group) compared with tissues never exposed to drug (control by analyzing gene expression cell‐surface heparan sulfate proteoglycans syndecan‐2, syndecan‐4 betaglycan. Material Methods: mRNA analysis...