A5103222286- COVID-19 Clinical Research Studies
- HIV Research and Treatment
- Long-Term Effects of COVID-19
- Cytomegalovirus and herpesvirus research
- T-cell and Retrovirus Studies
- Immune Cell Function and Interaction
- Cutaneous lymphoproliferative disorders research
- interferon and immune responses
- SARS-CoV-2 and COVID-19 Research
- Viral Infections and Vectors
- Herpesvirus Infections and Treatments
- COVID-19 and Mental Health
- Trypanosoma species research and implications
- Pregnancy and preeclampsia studies
- IL-33, ST2, and ILC Pathways
- Dermatology and Skin Diseases
- Reproductive System and Pregnancy
- Fungal Infections and Studies
- Immune Response and Inflammation
- Mosquito-borne diseases and control
- Cholesterol and Lipid Metabolism
- COVID-19 Impact on Reproduction
- Nutritional Studies and Diet
- Global Maternal and Child Health
- Fatty Acid Research and Health
Universidade de São Paulo
2014-2025
Instituto de Medicina Tropical
2019-2021
Hospital São Paulo
2014
American trypanosomiasis, also named Chagas disease (CD), is an anthropozoonosis caused by the protozoan parasite Trypanosoma cruzi. The affects millions of people worldwide, leading yearly to approximately 50,000 deaths. COVID-19, generated SARS-CoV-2, can lead lymphopenia and death. We hereby describe first report two patients with CD COVID-19 coinfection, from hospitalization until patients'
Immunosenescence, a process with dysfunctional immune response that may favor infection is associated an increase in inflammatory responses mediated by proinflammatory cytokines, characteristic of inflammaging. Aging and immunosenescence have relationship relating to oxidative stress Therefore, natural antioxidant compounds could be candidates for the control process. Our purpose was evaluate effect resveratrol (Resv) on antioxidant, antiviral, anti-inflammatory induced toll-like receptors...
Atopic dermatitis (AD) is a chronic inflammatory immune-mediated skin disease characterized by colonization Staphylococcus aureus. Interleukin (IL)-22, in cooperation with IL-17, triggers antimicrobial peptide elaboration and enhances certain immunological responses. In AD, IL-22 related to epidermal hyperplasia, keratinocyte apoptosis, inhibition of (AMP) production. We aimed evaluate the impact staphylococcal enterotoxins on Tc22/Th22 induction peripheral blood AD patients CD4
Mother-to-child transmission (MTCT) of HIV-1 has been significantly reduced with the use antiretroviral therapies, resulting in an increased number HIV-exposed uninfected infants. The consequences HIV infection on innate immune system both mother-newborn are not well understood. In this study, we analyzed peripheral blood and umbilical cord (CB) collected from HIV-1-infected pregnant women. We measured TNF-α, IL-10 IFN-α secretion after stimulation cells agonists extracellular Toll-like...
The severe respiratory and systemic disease named coronavirus disease-2019 (COVID-19) is caused by the acute syndrome 2 (SARS-CoV-2). Currently, COVID-19 pandemic presents a huge social health challenge worldwide. Many different risk factors are associated with severity, such as arterial hypertension, diabetes mellitus, obesity, older age, other co-infections. Other diseases chronic obstructive pulmonary (COPD) smoking common comorbidities Previous investigations have identified among...
Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). COVID-19 has infected over 90 million people worldwide, therefore it considered a pandemic. SARS-CoV-2 infection can lead to pneumonia, distress (ARDS), septic shock, and/or organ failure. Individuals receiving heart transplantation (HT) may be at higher risk of adverse outcomes attributable due immunosuppressives, as well concomitant infections that also influence the prognoses....
COVID-19, the infectious disease caused by SARS-CoV-2, has spread on a pandemic scale. The viral infection can evolve asymptomatically or generate severe symptoms, influenced presence of comorbidities. Lymphopenia based severity symptoms in patients affected with COVID-19 is frequent. However, profiles CD4+ and CD8+ T cells regarding cytotoxicity antiviral factor expression have not yet been completely elucidated acute SARS-CoV-2 infections. purpose this study was to evaluate phenotypic...
Innate immunity, including natural killer (NK) cells, may play a significant role in maintaining resistance to infection highly HIV-exposed seronegative (HESN) subjects. The differences between NK-cell subsets, regarding their activating/maturing marker expression and memory markers, HESN subjects are not fully defined.We have conducted an analysis of the activating/memory markers intracellular CD107a interferon γ (IFN-γ) subsets from HIV-infected healthy subjects.HESN individuals showed...
// Marina Passos Torrealba 1 , Kelly Cristina Manfrere Denis R. Miyashiro 2 Josenilson F. Lima Luana de M. Oliveira Nátalli Z. Pereira Jade Cury-Martins Juliana 3 Alberto J.S. Duarte Maria N. Sato 1, * and José A. Sanches 2, Medical Investigation Laboratory (LIM-56), Tropical Medicine Institute of São Paulo, Department Dermatology, University Paulo School, Brazil Cutaneous Lymphoma Clinic, Hospital das Clinicas, Hematology Department, These authors share the mentorship, critical revision...
Natural killer (NK) cells are the main mediator of cytotoxic response in innate immunity and may be involved resistance to HIV-1 infection exposed seronegative (ESN) individuals. Toll-like receptor (TLR) signalling is crucial for NK cell activation. Here, we investigated polyfunctional TLR3 activation serodiscordant couples. ESN subjects showed increased IFN-γ CD107a expression both subsets, CD56bright CD56dim cells, stimulation with a agonist, while was impaired HIV-1-infected partners....
Abstract Staphylococcus aureus colonizes the skin of atopic dermatitis (AD) individuals, but impact its enterotoxins on chronic activation CD4 + T cells demands further analysis. We aimed to analyze cell anergy profile and their phenotypic functional features through differential expression cellular markers, cytokine production response staphylococcal enterotoxin A (SEA). panel 84 genes relevant was assessed by PCR array in FACS-sorted cells, most prominent were validated RT-qPCR. evaluated...
Common clinical features of patients with Coronavirus disease-2019 (COVID-19) vary from fever, to acute severe respiratory distress syndrome. Several laboratory parameters are reported as indicators COVID-19 severity. We hereby describe the possible novel severity biomarkers for COVID-19, CD11b+CD33+HLA-DR-CD14+ cells and CD11b+CD33+HLA-DR-CD66b+ cells.
Programs for the prevention of mother-to-child transmission HIV have reduced rate perinatal infection and thereby increased number HIV-exposed uninfected (HEU) infants. Natural immunity to HIV-1 in both mothers newborns needs be further explored. In this study, we compared expression antiviral restricting factors HIV-infected pregnant treated with antiretroviral therapy (ART) pregnancy (n=23) cord blood (CB) (n=16), placental tissues (n=10-13) colostrum (n=5-6) samples them from (UN) (n=21)....
The literature presents several reports of the impact glycemic control and diabetes in inflammatory coagulatory response during coronavirus disease 2019 (COVID-19). Nevertheless, long-term COVID-19 diabetic patients is still to be explored. Therefore, we recruited 128 performed a longitudinal analysis on COVID-19-associated biomarkers with COVID-19, tree 6 months after recovery put into perspective possible complication generated COVID-19. In our investigation, failed verify any modification...
Abstract Zika virus (ZIKV) is a clinically important flavivirus that can cause neurological disturbances in newborns. Here, we investigated comparatively the outcome of vitro infection newborn monocytes by ZIKV. We observed neonatal cells show defective production interleukin 1β, 10, and monocyte chemoattractant protein 1 response to ZIKV, although they were as efficient adult supporting viral infection. Although CLEC5A classical immune receptor, it not essential cytokine response, but...
Sézary syndrome (SS) carries a poor prognosis, and infections represent the most frequent cause of death in SS patients. Toll-like receptors (TLRs) are family innate immune that induce protective responses against infections. We sought to evaluate ability TLR agonists inflammatory cytokine, Th2 type I interferon (IFN-I) production by peripheral blood mononuclear cells (PBMC) untreated detected impaired IL-6, IL-10 IL-13 secretion PBMC induced for TLR5, TLR3, TLR7 TLR9 patients, while it was...
Innate immunity is one of the main protection mechanisms against viral infections, but how this system works at maternal-fetal interface, especially during HIV infection, still poorly known. In work, we investigated relationship between pregnancy and innate associated to by evaluating expression DAMPs, inflammasome components type I/III IFNs in placenta serum samples from HIV-infected mothers exposed newborns. Our results showed that most these factors, including HMGB1, IL-1 IFN, were...
Abstract Vertical transmission is the main mechanism of human immunodeficiency virus type 1 (HIV-1) infection in infants, who may develop high viremia and rapidly progress to AIDS. Innate immunity agonists can control HIV-1 replication vitro, but protective effect neonatal period remains unknown. Herein, we evaluated immunomodulatory antiviral effects I interferon (IFN-I) adjuvants on cord blood monocyte-derived macrophages upon infection. Despite phenotypic transcriptional similarities...
Obesity is increasing in incidence worldwide, especially women, which can affect the outcome of pregnancy. During this period, viral infections represent a risk to mother, placental unit, and fetus. The Zika virus (ZIKV) outbreak Brazil has been cause congenital syndrome (CZS), with devastating consequences such as microcephaly newborns. Herein, we analyzed impact maternal overweight/obesity on antiviral factors’ expression tissue Zika-infected mothers. We accessed placentas from women...
Abstract Individuals who remain HIV-seronegative despite repeated unprotected exposure to the virus are defined as exposed seronegative (ESN) individuals. Innate and adaptive immunity, well genetic factors, provide ESNs with important advantages that allow for low infection susceptibility. The majority of HIV-1-infected individuals undergo antiretroviral therapy, which can decrease level HIV-1 in ESNs. We analyzed type I interferon (IFN)-related antiviral regulatory factors peripheral blood...
COVID-19, the infectious disease caused by SARS-CoV-2, has spread on a pandemic scale. The virus infection can evolve asymptomatically or generate severe symptoms, influenced presence of comorbidities. Lymphopenia in patients affected with COVID-19 according to severity symptoms is frequent. However, profile CD4+ and CD8+ T-cells regarding cytotoxicity antiviral factor expression not yet been completely elucidated acute SARS-CoV-2 infections. purpose this study evaluate phenotypic functional...