A5039985657- Cutaneous lymphoproliferative disorders research
- Fungal Infections and Studies
- Autoimmune Bullous Skin Diseases
- Nail Diseases and Treatments
- Research on Leishmaniasis Studies
- Cancer and Skin Lesions
- Genetic and rare skin diseases.
- Cutaneous Melanoma Detection and Management
- Skin and Cellular Biology Research
- Leprosy Research and Treatment
- Nonmelanoma Skin Cancer Studies
- Urticaria and Related Conditions
- Dermatology and Skin Diseases
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Autoimmune and Inflammatory Disorders
- Mycobacterium research and diagnosis
- Oral Health Pathology and Treatment
- Mast cells and histamine
- T-cell and Retrovirus Studies
- Hedgehog Signaling Pathway Studies
- Systemic Lupus Erythematosus Research
- Antifungal resistance and susceptibility
- Immunotherapy and Immune Responses
- Dermatological and Skeletal Disorders
- Trypanosoma species research and implications
Universidade de São Paulo
2015-2024
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
2011-2024
Instituto de Medicina Avançada
2021
Hospital de Clínicas da Unicamp
2019
Hospital Universitário da Universidade de São Paulo
2012
Universidade Brasil
2005-2011
Hospital São Paulo
2005
Instituto de Medicina Tropical
2004
Brazilian Society of Tropical Medicine
2003
Hospital for Tropical Diseases
1996
Abstract Background Atopic dermatitis (AD) in adults and profile of skin barrier proteins inflammatory cytokines. Objective Evaluation the expression such as filaggrin, claudins 1 4 circulating cytokines (Th1/Th2/Th17) with AD. Methods Thirty‐three adult patients AD diagnosed according to Hanifin & Rajkacriteria, 25 healthy controls were enrolled study. severity was measured by Eczema Area Severity Index (EASI). Laboratory assays included immunohistochemistry analysis proteins,...
Background: Lupus erythematosus (LE) is a multifactorial autoimmune disease, which may affect the oral mucosa in either its cutaneous and systemic forms, with varied prevalence. Methods: Forty‐six patients confirmed diagnosis of LE, presenting lesions were included study. Oral mucosal analyzed clinically, their histopathological features investigated inflammatory infiltrate constitution was assessed using immunohistochemistry against following clusters differentiation: CD3, CD4, CD8, CD20,...
Biopsy specimens of the skin were taken from 10 patients with acute meningococcemia who exhibited mainly maculopurpuric lesions. The studied by light, electron, and immunofluorescent microscopy in an attempt to obtain information on pathogenesis vascular injury. Light disclosed a large number Neisseria meningitidis organisms, both endothelial cells being phagocytized neutrophils. Vascular injury was characterized (by means light electron microscopy) necrosis, thrombosis, necrosis other...
Oral mucosal melanoma is rare and reported to be more aggressive than its cutaneous counterpart. Due the rarity of this entity, data on epidemiology, tumor behavior, treatment, follow-up, survival patients are mainly based single case reports. The few existing series show that oral mucosa has peak between 41 60 years age, male female ratio 2:1. Preferred sites include hard palate maxillary alveolar crests. Risk factors have not been clearly identified, surgical treatment still choice for...
Abstract Background Cutaneous tuberculosis has re‐emerged in the last 15 years together with higher incidence of pulmonary and multidrug resistance. The choice for a single diagnostic tool among many available today is challenge. Our objective was to compare polymerase chain reaction (PCR) other exams diagnosis cutaneous atypical mycobacteria skin infection. Methods PCR set five different were performed 32 patients (34 samples paraffin‐embedded tissue) evaluated 3 university hospital,...
Actinic cheilitis (AC) is considered to be a pre-malignant lesion or an incipient and superficial form of lip squamous cell carcinoma. It commonly found in individuals whose occupational activities are related chronic sun exposure the definitive diagnosis performed with biopsy. Althoug Exfoliative cytology has been used as screening procedure evaluate cancer oral cavity no studies have proposed use exfoliative cytologic analysis diagnose AC. The purpose this study was lower lesions on...
GAPO syndrome was described in 12 patients from 7 families. Constant manifestations include dwarfism, alopecia, pseudoanodontia, and a peculiar, "geriatric" facial appearance. We describe the autopsy findings all available clinical data on one deceased patient his living affected sister, previously reported as short abstracts (Epps et al.: Cienc Cult 29(Suppl):740, 1977; Wajntal 34(Suppl):705, 1982). Both had characteristic anomalies of this but optic atrophy absent; instead, they glaucoma...
Since macrophages are one of the major cell types involved in Mycobacterium leprae immune response, roles M1 and M2 macrophage subpopulations have been well defined. However, role M4 leprosy or other infectious diseases caused by mycobacteria has not yet clearly characterized. This study aimed to investigate presence potential immunopathology leprosy.We analyzed markers (CD68, MRP8, MMP7, IL-6, TNF-α) 33 skin lesion samples from 18 patients with tuberculoid 15 lepromatous...
Atopic dermatitis (AD) is a chronic inflammatory immune-mediated skin disease characterized by colonization Staphylococcus aureus. Interleukin (IL)-22, in cooperation with IL-17, triggers antimicrobial peptide elaboration and enhances certain immunological responses. In AD, IL-22 related to epidermal hyperplasia, keratinocyte apoptosis, inhibition of (AMP) production. We aimed evaluate the impact staphylococcal enterotoxins on Tc22/Th22 induction peripheral blood AD patients CD4
Leprosy is a disease caused by Mycobacterium leprae (ML) with diverse clinical manifestations, which are strongly correlated the host’s immune response. Skin lesions may be accompanied peripheral neural damage, leading to sensory and motor losses, as well deformities of hands feet. Both innate acquired responses involved, but has been classically described along Th1/Th2 spectrum, where Th1 pole corresponds most limited presentations Th2 disseminated ones. We discuss this dichotomy in light...
We demonstrated and quantified by immunohistochemistry epidermal Langerhans cells, CD34+ dermal dendrocytes (DDs), cells expressing TNFα, interferon-γ (IFNγ), IL-5, IL-10 in skin lesions of paracoccidioidomycosis (PCM). Sixty-one biopsies were classified three groups according to the pattern tissue response: Group 1, well-organized granuloma; 2, poorly organized 3, both kinds granuloma. had short irregular dendrites all decreased number Groups 1 2. DDs did not differ from control group. was...
Epidermolysis bullosa acquisita (EBA) is a subepidermal blistering disease with IgG antibodies against collagen VII. The heterogeneous and can lead to significant morbidity.To characterize the clinical laboratory profile of patients EBA from Sao Paulo, Brazil.In total, 12 (mean age 24 years) were analysed for cutaneous mucosal involvement, data response treatment.Mucosal involvement occurred in 11 (eyes 4/12, nose 4/9, pharynx-larynx 5/9 oesophagus 4/10; 3 did not undergo nasopharyngeal...
There are few studies on the role of innate immune response in dermatophytosis. An investigation was conducted to define involvement Toll-Like Receptors (TLRs) 2 and 4 localized (LD) disseminated (DD) dermatophytosis due T. rubrum. Fifteen newly diagnosed patients, eight patients with LD seven DD, defined by at least three body segments were used this study. Controls comprised twenty skin samples from healthy individuals undergoing plastic surgery. TLR2 TLR4 quantified lesions...
Background Chromoblastomycosis is a chronic fungal infection that affects skin and subcutaneous tissue. Lesions can be classified in tumorous, verrucous, cicatricial plaque type. The cellular immune response the severe form of disease seems to correlate with Th2 pattern cytokines. humoral also play role. We intended explore populations regulatory T cells Th17 pattern. Methodology Twenty-three biopsies verrucous were obtained from patients clinical, culture histopathological diagnostic...