A5018643002- Cutaneous lymphoproliferative disorders research
- T-cell and Retrovirus Studies
- Fungal Infections and Studies
- Lymphoma Diagnosis and Treatment
- Infant Nutrition and Health
- Histiocytic Disorders and Treatments
- Lymphatic System and Diseases
- Cancer, Lipids, and Metabolism
- CAR-T cell therapy research
- Vascular Tumors and Angiosarcomas
- Dermatology and Skin Diseases
- Lipid metabolism and biosynthesis
- Neonatal Respiratory Health Research
- Autoimmune Bullous Skin Diseases
- Ubiquitin and proteasome pathways
- Immune Cell Function and Interaction
- Urticaria and Related Conditions
- Immune Response and Inflammation
- Chronic Lymphocytic Leukemia Research
- Allergic Rhinitis and Sensitization
Universidade de São Paulo
2016-2024
University of Copenhagen
2022
Maersk (Denmark)
2022
LEO Foundation
2022
Sézary syndrome (SS) is a rare and aggressive type of cutaneous T-cell lymphoma, with an abnormal inflammatory response in affected skin. The cytokines IL-1B IL-18, as key signaling molecules the immune system, are produced inactive form cleave to active by inflammasomes. In this study, we assessed skin, serum, peripheral mononuclear blood cell (PBMC) lymph-node samples SS patients control groups (healthy donors (HDs) idiopathic erythroderma (IE) nodes) investigate markers IL-18 at protein...
// Marina Passos Torrealba 1 , Kelly Cristina Manfrere Denis R. Miyashiro 2 Josenilson F. Lima Luana de M. Oliveira Nátalli Z. Pereira Jade Cury-Martins Juliana 3 Alberto J.S. Duarte Maria N. Sato 1, * and José A. Sanches 2, Medical Investigation Laboratory (LIM-56), Tropical Medicine Institute of São Paulo, Department Dermatology, University Paulo School, Brazil Cutaneous Lymphoma Clinic, Hospital das Clinicas, Hematology Department, These authors share the mentorship, critical revision...
Atopic dermatitis (AD) is a chronic and relapsing inflammatory cutaneous disease. The role of host defense microbial virulence factors in Staphylococcus aureus skin colonization, infection, inflammation perpetuation AD remains an area current research focus. Extracellular vesicles (EV) mediate cell-to-cell communication by transporting delivering bioactive molecules, such as nucleic acids, proteins, enzymes, to recipient cells. spontaneously secretes extracellular (SA-derived EVs), which...
Sézary syndrome (SS) carries a poor prognosis, and infections represent the most frequent cause of death in SS patients. Toll-like receptors (TLRs) are family innate immune that induce protective responses against infections. We sought to evaluate ability TLR agonists inflammatory cytokine, Th2 type I interferon (IFN-I) production by peripheral blood mononuclear cells (PBMC) untreated detected impaired IL-6, IL-10 IL-13 secretion PBMC induced for TLR5, TLR3, TLR7 TLR9 patients, while it was...
// Kelly C.G. Manfrere 1 , Marina P. Torrealba Denis R. Miyashiro 2 Nátalli Z. Pereira Fabio S.Y. Yoshikawa Luana de M. Oliveira Jade Cury-Martins Alberto J.S. Duarte José A. Sanches 2, * and Maria N. Sato 1, Laboratory of Medical Investigation, LIM-56, Department Dermatology, Tropical Medicine Institute São Paulo, University Paulo School, Brazil Cutaneous Lymphoma Clinic, Hospital das Clínicas, These authors share the mentorship, critical revision supervision this study Correspondence to:...
Abstract Although the neonatal period is characterized by relative immunological immaturity, an inflammatory response due to Toll-like receptor (TLR) activation observed. Histamine may be one of factors playing a role in restraining inflammation during early stages life. Therefore, we evaluated responsiveness human cord blood cells TLR4 agonists and immunomodulatory function histamine response. Compared with adults, mononuclear (MNCs) from newborns (NBs) exhibit impaired production...
Cutaneous T cell lymphoma (CTCL) is a group of non-Hodgkin’s primary cutaneous lymphomas, with Mycosis Fungoides and Sézary syndrome (SS) being the two most common subtypes. Fatty acid synthase (FASN) crucial enzyme that catalyses biosynthesis fatty acids, which has been reported to play an oncogenic role in various malignancies but not CTCL so far. Herein, we show FASN highly expressed lines peripheral blood mononuclear cells (PBMCs) from patients, while it PBMCs healthy individuals. The...
Sézary syndrome (SS) is a malignancy of CD4+ central memory T-lymphocytes, characterized by the triad erythroderma, lymphadenopathy, and involvement peripheral blood neoplastic cells. We describe rare case double-positive CD4 CD8 SS. An 83-year-old man presented to our clinic with pruritic skin lesions 7 months' duration. The physical examination revealed nonscarring diffuse alopecia, palmoplantar keratoderma, onychodystrophy, edema lower limbs, ectropion, without lymphadenopathy or weight...