A5102854428- Breast Cancer Treatment Studies
- S100 Proteins and Annexins
- Breast Lesions and Carcinomas
- Genital Health and Disease
- Pelvic floor disorders treatments
- Urologic and reproductive health conditions
- Cancer and Skin Lesions
- Urological Disorders and Treatments
- Chronic Myeloid Leukemia Treatments
- Urticaria and Related Conditions
- HER2/EGFR in Cancer Research
- Sexual function and dysfunction studies
- Urinary Bladder and Prostate Research
- Advanced Radiotherapy Techniques
- Cardiac, Anesthesia and Surgical Outcomes
- Epigenetics and DNA Methylation
- Cannabis and Cannabinoid Research
- Angiogenesis and VEGF in Cancer
- Traumatic Brain Injury and Neurovascular Disturbances
- Cancer, Hypoxia, and Metabolism
- Pelvic and Acetabular Injuries
- Sepsis Diagnosis and Treatment
- Radiopharmaceutical Chemistry and Applications
- Head and Neck Cancer Studies
- Lanthanide and Transition Metal Complexes
Clinical Research Center Kiel
2019-2022
University of Michigan
2021
University Hospital Schleswig-Holstein
2004-2019
University of Lübeck
2004-2019
Klinik für Frauenheilkunde
2004-2019
Universidad Autónoma de Madrid
2015
Centre for Biomedical Network Research on Rare Diseases
2015
Consejo Superior de Investigaciones Científicas
2015
Centro de Biología Molecular Severo Ochoa
2015
Research Institute Hospital 12 de Octubre
2015
Pharmacological activation of cannabinoid receptors elicits antitumoral responses in different cancer models. However, the biological role these tumor physio-pathology is still unknown. We analyzed CB2 receptor protein expression two series 166 and 483 breast samples operated University Hospitals Kiel, Tübingen, Freiburg between 1997 2010 mRNA previously published DNA microarray datasets. The oncogenesis was studied by generating a mouse line that expresses human V-Erb-B2 Avian...
// Clara Andradas 1, 2 , Sandra Blasco-Benito Sonia Castillo-Lluva 1 Patricia Dillenburg-Pilla 3 Rebeca Diez-Alarcia 4 Alba Juanes-García 5 Elena García-Taboada Rodrigo Hernando-Llorente Joaquim Soriano 6 Sigrid Hamann 7 Antonia Wenners Ibrahim Alkatout Wolfram Klapper 8 Christoph Rocken Maret Bauer Norbert Arnold Miguel Quintanilla 9 Diego Megías Vicente-Manzanares Leyre Urigüen J. Silvio Gutkind 3, 10 Manuel Guzmán 11 Eduardo Pérez-Gómez...
Abstract Background Breast cancer treatment is based on a combination of adjuvant chemotherapy followed by radiotherapy effecting intracellular signal transduction. With the tyrosine kinase inhibitors new targeted drugs are available. Imatinib mesylate selective inhibitor bcr-abl, PRGFR alpha, beta and c-kit. The purpose this study was to determine whether has an influence effectiveness in breast cell lines if imatinib with standard could lead increased cytoreduction. Methods Colony-forming...
In our previous work we showed that NGAL, a protein involved in the regulation of proliferation and differentiation, is overexpressed human breast cancer (BC) predicts poor prognosis. neoadjuvant chemotherapy (NACT) pathological complete response (pCR) predictor for outcome. The aim this study was to evaluate NGAL as NACT validate prognostic factor clinical outcome patients with primary BC. Immunohistochemistry performed on tissue microarrays from 652 core biopsies BC patients, who underwent...
Although several clinical studies have shown that increased serum concentrations of protein S100B predict ischaemic brain damage after cardiac surgery, may also be released from the heart or other injured tissue. We therefore investigated correlation between levels and those specific marker troponin I in order to assess cerebral vs. extracerebral origin S100B. In 64 surgical patients, serial blood samples were drawn for measurement before surgery seven days surgery. Neurological function was...
Male breast cancer (MBC) is rare, and most previous studies limited their focus on clinical aspects of the disease. Psychosocial implications care needs MBC patients are poorly understood.The aim this study to explore experiences men living with identify supportive needs.Eighteen were interviewed using qualitative, semi-structured telephone interviews. Qualitative content analysis was used analyze data.The majority did not have negative feelings about having a "women's disease," although...
<b><i>Background:</i></b> Imatinib is a tyrosine kinase inhibitor of BCR-ABL, ABL, PDGFR-α and -β, KIT, DDR. In solid tumors, it inhibits proliferation invasiveness facilitates higher intratumoral cytotoxic drug concentrations. Vinorelbine has good tolerability efficacy in metastatic breast cancer (MBC). This study evaluates the safety imatinib vinorelbine combination. <b><i>Methods:</i></b> prospective, open-label, phase I/II trial, 400 mg...
Background and Aims: In colorectal cancer patients’ mortality is largely influenced by spreading of tumour cells from the primary site subsequent metastasis formation. CD44 an adhesion molecule represents a highly variable family isoforms. The isoform CD44v6 has been associated with metastatic spread poor prognosis in animal models several human cancers. Results immunohistological studies are mostly retrospective contradictory. aim our prospective study was to assess controversial role as...
relationships, and sexuality
From May 1, 1992, to April 30, 1993, we performed 307 ultrasonic guided high-speed punch biopsies. In 119 of the women, dispensed with further surgical and histological procedures when tentative diagnosis from complementary mammary diagnostic revealed no pathological findings concurred results biopsy. 188 biopsy was followed by intervention correlation findings. This group patients showed a sensitivity 98%, specificity positive prognostic value 100%, negative 91%. If combine (including...
In der Zeit von 10/1987 bis 10/1991 wurden bei 150 Patientinnen Universitäts-Frauenklinik Freiburg eine kernspintomographische Beckenmessung (MRI) (Flußdichte 0,23 Tesla) durchgeführt, davon 135 Frauen "ante partum" bzw. unter Geburt. Die Indikationen waren: vorausgehende operative oder stark protrahierte Entbindung, klinischer Verdacht auf KopfBecken-Mißverhältnis geburtshilfliches Problembecken aufgrund manueller Beckenaustastung Ultraschall-Fetometrie. Zuvor durchgeführte experimentelle...
In the period 1981-86, 22 patients with local inoperable tumour recurrences in mouth and pharynx area had endocavitary contact therapy using a remote-controlled afterloading system at Radiotherapy Centre of University Heidelberg. All previous surgery external-beam radiation; some also received chemotherapy. The technique is described preliminary results are discussed.