A5075082156- Venomous Animal Envenomation and Studies
- Phytoestrogen effects and research
- Antimicrobial Peptides and Activities
- Seaweed-derived Bioactive Compounds
- Bee Products Chemical Analysis
- Healthcare and Venom Research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Nutrition, Genetics, and Disease
- Estrogen and related hormone effects
- Cell death mechanisms and regulation
- Advanced Breast Cancer Therapies
- PARP inhibition in cancer therapy
- Protein Hydrolysis and Bioactive Peptides
- Bioactive natural compounds
- Nicotinic Acetylcholine Receptors Study
- Cancer therapeutics and mechanisms
- Sirtuins and Resveratrol in Medicine
- Acute Lymphoblastic Leukemia research
- Skin Protection and Aging
- interferon and immune responses
Universidade de São Paulo
2019-2024
Universidade Brasil
2023
Universidade de Ribeirão Preto
2019
Breast cancer is the neoplasm with both highest incidence and mortality rate among women worldwide. Given known snake venom cytotoxicity towards several tumor types, we evaluated effects of BthTX-I from Bothrops jararacussu on MCF7, SKBR3, MDAMB231 breast cell lines.BthTX-I was determined via MTT 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrazoliumbromide assay. Cell death measured by a hypotonic fluorescent solution method, annexin-V-FITC/propidium iodide staining apoptotic/autophagic...
Breast cancer stands as the most prevalent type of tumor and a significant contributor to cancer-related deaths. Among its various subtypes, triple-negative breast (TNBC) presents worst prognosis due aggressive nature absence effective treatments. Crotoxin, protein found in venom Crotalus genus snakes, has demonstrated notable antitumor activity against solid tumors. However, application been hindered by substantial toxicity humans. In efforts address this challenge, Crotoxin B-derived...
Introduction: The third-generation of aromatase inhibitors (AIs)—Exemestane (Exe), Letrozole (Let), and Anastrozole (Ana)—is the main therapeutic approach applied for estrogen receptor-positive (ER+) breast cancer (BC), most common neoplasm in women worldwide. Despite their success, development resistance limits efficacy. Genistein (G), a phytoestrogen present soybean, has promising anticancer properties ER+ BC cells, even when combined with drugs. Thus, potential beneficial effects...
Treatments that attenuate the effects of hypoestrogenism in menopausal women have been gaining visibility. This study investigated skin response to a phytoestrogen-enriched cosmetic formulation created by incorporating biotransformed soybean extract (BE) into cream-like matrix. Collagen-I expression was analyzed both vitro (fibroblast cells) and ex vivo (skin explants). The results revealed an increased amount collagen-I fibroblasts human when treated with BE BE-incorporated cream. Also,...
Aglycone isoflavones are estrogen-like bioactive compounds found in low amounts soybean, which increased by biotransformation processes. This study investigated two processes of soybean extracts with Aspergillus awamori fungus, evaluating aglycone content and capability stimulation collagen-I deposition. Isoflavones were quantified via HPLC; cytotoxicity biotransformed toward mouse human fibroblasts was evaluated NRU apoptosis/necrosis assays; deposition measured through Western blot,...
Abstract Breast cancer is the most prevalent type of tumor and a major leading cause mortality. Triple-negative breast (TNBC) has worst prognosis due to its malignant characteristics absence efficacious treatments. Crotoxin, protein in Crotalus genus snake venom, proven antitumor activity against aggressive solid tumors, but marked toxicity humans. Crotoxin B-derived peptides were synthesized evaluated vitro for their activity, which resulted discovery 3-NAntC. 3-NAntC (1µg/mL) treatment 72...