A5035456843- Toxoplasma gondii Research Studies
- Parasitic Infections and Diagnostics
- Herpesvirus Infections and Treatments
- Redox biology and oxidative stress
- Cytomegalovirus and herpesvirus research
- Education and Digital Technologies
- Antimicrobial agents and applications
- Microbial infections and disease research
- Bacteriophages and microbial interactions
- Synthesis and Characterization of Heterocyclic Compounds
- Education Pedagogy and Practices
- RNA Interference and Gene Delivery
- Pneumocystis jirovecii pneumonia detection and treatment
- Neuroscience and Neuropharmacology Research
- Memory and Neural Mechanisms
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Business and Management Studies
Universidade de São Paulo
2014-2022
Instituto de Ciências Farmacêuticas
2021
Abstract Neospora caninum is an Apicomplexan parasite related to important losses in livestock, causing abortions and decreased fertility affected cows. Several chemotherapeutic strategies have been developed for disease control; however, no commercial treatment available. Among the candidate drugs against neosporosis, phenothiazinium dyes, offer a low cost-efficient approach control. We report anti-parasitic effects of phenothiaziums Methylene Blue (MB), New (NMB), 1,9–Dimethyl (DMMB)...
Abstract Neospora caninum is an apicomplexan parasite that causes abortion in cattle, resulting significant economic losses. There no commercial treatment for neosporosis, and drug repositioning a fast strategy to test possible candidates against N. caninum. In this article, we describe the effects of atovaquone, chloroquine, quinine, primaquine tetracycline on proliferation. The IC50 concentrations were compared current information based previous studies Plasmodium Toxoplasma gondii,...
Abstract Apicomplexan parasites have unconventional actins that play a central role in important cellular processes such as apicoplast replication, motility of dense granules, endocytic trafficking and force generation for host cell invasion. In this study, we investigated the actin apicomplexan Neospora caninum – parasite associated with infectious abortion neonatal mortality livestock. was detected identified two bands by one-dimensional (1D) western blot nine spots 2D technique. The mass...
Neospora caninum is an obligate intracellular parasite related to cases of abortion and fertility impairment in cattle. The control the still lacks effective protective strategy understanding key mechanisms for host infection might be crucial identification specific targets. There are many proteins important cell cycle such as adhesion, invasion, proliferation immune evasion. surface proteins, especially SRS (Surface Antigen Glycoprotein – Related Sequences), have been demonstrated a pivotal...
Neospora caninum is a member of Apicomplexa Phylum and the causative agent neosporosis, disease responsible for abortions in cattle. Apicomplexan parasites have limited set actin-binding proteins conducting regulation dynamics nonconventional actin. The parasite actin-based motility implicated invasion process host cell. Once no commercial strategy neosporosis control available, interference actin function may result novel drug targets. Actin-depolymerization factor (ADF) ADF/cofilin family,...
Abstract Myeloproliferative neoplasms (MPN) are hematological disorders characterized by increased proliferation of precursor and mature myeloid cells. MPN patients may present driver mutations in JAK2 , MPL CALR genes, which essential to describe the molecular mechanisms pathogenesis. Despite all new knowledge on pathogenesis, many questions remain be answered develop effective therapies cure or impair its progression acute leukemia. The study examined expression levels Hippo signaling...