A5003052957- Phytochemistry Medicinal Plant Applications
- Essential Oils and Antimicrobial Activity
- Natural product bioactivities and synthesis
- Pharmacological Effects of Natural Compounds
- Phytochemistry and Biological Activities
- Neuropeptides and Animal Physiology
- Pain Mechanisms and Treatments
- Neuroscience and Neuropharmacology Research
- Receptor Mechanisms and Signaling
- Bioactive Compounds and Antitumor Agents
- Synthesis and biological activity
- Cholinesterase and Neurodegenerative Diseases
- Ginkgo biloba and Cashew Applications
- Phytochemistry and Bioactivity Studies
- Neurotransmitter Receptor Influence on Behavior
- Inflammatory mediators and NSAID effects
- Natural Compound Pharmacology Studies
- Bioactive Natural Diterpenoids Research
- Tryptophan and brain disorders
- Alkaloids: synthesis and pharmacology
- Computational Drug Discovery Methods
- Stress Responses and Cortisol
- Plant Toxicity and Pharmacological Properties
- Biological Stains and Phytochemicals
- Medicinal Plant Extracts Effects
Universidade Federal de Goiás
2016-2025
Universidade Federal de São Paulo
2024
Natura (Brazil)
2015-2016
Universidade de São Paulo
2015
Department of Physiological Sciences
2014
Sapienza University of Rome
2010
Spiranthera odoratissima A. St. Hil. (manacá) is used in folk medicine to treat renal and hepatic diseases, stomachache, headaches rheumatism. A central nervous system (CNS) depressant effect of the hexane fraction from ethanolic extract this plant has been described. β-caryophyllene, main component essential oil, a sesquiterpene compound with anti-inflammatory properties that found oils derived several medicinal plants. This work aimed evaluate pharmacological activity oil obtained S....
To identify the compounds responsible for antinociceptive and anti-inflammatory effects previously described Sedum dendroideum, through bioassay-guided fractionation procedures.Antinociceptive activity was evaluated mouse acetic acid-induced writhing model. The assessed croton oil-induced ear oedema carrageenan-induced peritonitis.The dendroideum juice afforded seven known flavonoids identified with basis on NMR data. oral administration of major kaempferol glycosides kaempferitrin [1]...
Lafoensia pacari A. St.-Hil. (Lythraceae) has been referred in Brazilian traditional medicine for the treatment of different diseases, among them depression. Nevertheless, there are not studies about this possible effect on central nervous system (CNS). To evaluate antidepressant-like effects ethanolic extract (PEtExt) and its fractions performance male mice. Antidepressant activity was studied using forced swimming (FST) tail suspension (TST) tests, motor open-field test. The were...
Our study sought to evaluate the anxiolytic and antidepressant activities of oleanolic acid as well neural mechanisms involved. Animal models such barbiturate sleep-induction, light–dark box, elevated plus maze, forced swimming test, tail suspension test open field were conducted. Male Albino Swiss mice treated orally with vehicle 10 mL/kg, fluoxetine 20 mg/kg, imipramine 15 diazepam 1 mg/kg or 5–40 mg/kg. Pretreatment (intraperitoneal) animals pentylenetetrazole (PTZ)...
Gastric ulcer affects people worldwide, and its inefficacy recurrence have fueled the search for new therapeutic strategies. Despite well-known use of allantoin in medicines cosmetic products, effect has not yet been studied with regard to gastric ulcer. Hence, aim present study was explore pharmaco-mechanistic efficacy against commonly harmful agents that cause injuries stomach. Ethanol, indomethacin, stress-induced models were adopted, addition pylorus ligature, a quantification vascular...
The leaves and stems bark of Memora nodosa (Silva Manso) Miers (Bignoniaceae) are used in Brazilian traditional medicine the treatment external ulcers wounds; its roots to treat abdominal pain scabies.Our aim was evaluate antinociceptive anti-inflammatory activities ethanolic extract (EMN) allantoin, a secondary metabolite isolated from this plant.The EMN allantoin activity were evaluated mice using both chemical heat-induced models such as acetic acid-induced writhing, formalin tail-flick...
Kalanchoe pinnata (KP) is popularly used for treating inflammatory diseases. This study investigated the antinociceptive, antiedematogenic, and anti‐inflammatory potential of subcutaneous administration KP flower aqueous extract (KPFE), its ethyl acetate (EtOAcF) butanol (BuOHF) fractions, main flavonoid [quercetin 3‐ O ‐ α ‐L‐arabinopyranosyl (1 → 2) ‐L‐rhamnopyranoside] (KPFV) in mice, as well possible mechanisms action. KPFE (30–300 mg/kg) KPFV (1–10 inhibited acetic acid‐induced writhing...
The cashew gum (Anacardium occidentale L.) is used in traditional Brazilian medicine the treatment of inflammatory conditions, asthma, diabetes, and gastrointestinal disturbances.In present study, we aimed at forming a chemical characterization investigation antinociceptive anti-inflammatory activities aqueous extract without presence polysaccharides its composition (CGE).The CGE was obtained after precipitation removal through use acetone. After, acetone removed by rotaevaporation,...
<title>Abstract</title> <italic>Celtis iguanaea</italic>, widely used in Brazilian folk medicine, is known for its gastroprotective properties. This study aimed to develop a spray-dried hydroethanolic leaf extract of <italic>C. iguanaea</italic> (SDCi) and evaluate efficacy mice. A Box-Behnken design with three factors at levels (n = 15) Response Surface Methodology (RSM) were optimize the spray drying. The variables studied drying air inlet temperature (IT, 100–140°C), feed flow rate (Ef,...
Maprotiline, which differs from other typical tricyclic antidepressants for its tetracyclic structure, is a highly selective inhibitor of norepinephrine reuptake. Despite in vitro and vivo inhibitory activity on NE uptake, 21 repeated daily injections maprotiline (20 mg/kg i.p.) neither attenuated the norepinephrine-stimulated cAMP accumulation nor reduced number beta adrenergic recognition sites rat frontal cortex. Also, brain serotonin2 labeled by [3H]ketanserin remained virtually...
The pyrazol compounds are known to possess antipyretic, analgesic and anti-inflammatory activities. This study was conducted investigate the peripheral antinociceptive effect of pyrazole compound 5-(1-(3-Fluorophenyl)-1H-pyrazol-4-yl)-2H-tetrazole (LQFM-021) involvement opioid receptors NO/cGMP/KATP pathway. oral treatments in mice with LQFM-021 (17, 75 or 300 mg/kg) decreased number writhing. In formalin test, at doses 15, 30 60 mg/kg reduced licking time both neurogenic inflammatory phases...
The pyrazole compound LQFM-021 exhibits vasorelaxant, antinociceptive and anti-inflammatory activities. Furthermore, it has low toxicity, indicating that this may be considered to a good prototype for the development of new analgesic/anti-inflammatory drugs. Therefore, aim study was investigate potential activity using model carrageenan-induced inflammation as well mechanism action role nitric oxide in effect. Acute treatments with (30 60 mg/kg p.o.) reduced paw edema formation...
The mechanisms of action involved in the vasorelaxant effect gallic acid (GA) were examined isolated rat thoracic aorta. GA exerted a relaxant highest concentrations (0.4-10mM) both endothelium-intact and endothelium-denuded aortic rings. Pre-incubation with L-NAME, ODQ, calmidazolium, TEA, 4-aminopyridine, barium chloride significantly reduced pEC50 values. Moreover, this was not modified by indomethacin, wortmannin, PP2, glibenclamide, or paxillin. (1, 3, 10mM) Ca(2+)-free Krebs solution...
Abstract Objectives To evaluate whether the glycosylation of chrysin (CHR) enhances its protective effects against aluminum-induced neurotoxicity. Methods compare antioxidant, anticholinesterase, and behavioral CHR with glycosylated form (CHR bonded to β-d-glucose tetraacetate, denoted as LQFM280), we employed an integrated approach using both in vitro (SH-SY5Y cells) vivo (aluminum-induced neurotoxicity Swiss mice) models. Key findings LQFM280 demonstrated higher antioxidant activity than...
(E)-methyl isoeugenol (MIE) is a natural food flavour that constitutes 93.7% of an essential oil from Pimenta pseudocaryophyllus leaf. The leaf extracts this species are used as calming agent. As ubiquitous additive, the application MIE for treating mood disorders appears to be globally attractive. Hence, we sought evaluate general pharmacological activities, anticonvulsant, anxiolytic and antidepressant effects possible mechanisms actions. Administration was carried out prior exposure male...
Pequi ( Caryocar brasiliense ) is an endemic species from Brazilian Cerrado, and their fruits are widely used in regional cuisine. In this work, a crude hydroalcoholic extract (CHE) of C. leaves its resulting fractions hexane (HF), chloroform (CF), ethyl acetate (EAF), butanol (BF) were investigated for antioxidant properties anticholinesterase activities. The evaluated by free radical scavenging electroanalytical assays, which further correlated with the total phenolic content LC‐MS...
The antinociceptive and antiinflammatory properties of the neolignan, grandisin, isolated from Virola surinamensis (Myristicaceae) were investigated. Grandisin (GRA) is present in several plant species Brazil used popular medicine for treatment disorders such as colic, inflammation, rheumatism, dyspepsia liver dysfunction. These studies demonstrated that GRA able to inhibit acetic acid-induced writhing mice dose-dependently, this effect not caused by motor incoordination or sedation due...
Preparations from Pimenta pseudocaryophyllus (Gomes) L.R. Landrum (Myrtaceae) have been widely used in Brazilian folk medicine. This study aims to evaluate the antimicrobial activity of crude ethanol extracts, fractions, semipurified substances, and essential oils obtained leaves two chemotypes P. perform antinociceptive anti-inflammatory screening. The extracts were purified by column chromatography main compounds spectrally characterised (1D 2D (1)H (13)C NMR). constituents identified...