A5101533716- Ferroptosis and cancer prognosis
- MicroRNA in disease regulation
- Epigenetics and DNA Methylation
- Metal complexes synthesis and properties
- Circular RNAs in diseases
- Genetics and Neurodevelopmental Disorders
- Garlic and Onion Studies
- Caveolin-1 and cellular processes
- Pancreatic and Hepatic Oncology Research
- 14-3-3 protein interactions
- PI3K/AKT/mTOR signaling in cancer
- Photodynamic Therapy Research Studies
- RNA modifications and cancer
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer-related gene regulation
- Cancer, Hypoxia, and Metabolism
- Cancer Research and Treatments
- Toxin Mechanisms and Immunotoxins
- Genetic Syndromes and Imprinting
- Synthesis and Biological Evaluation
- Angiogenesis and VEGF in Cancer
- Galectins and Cancer Biology
- Endoplasmic Reticulum Stress and Disease
- Transgenic Plants and Applications
- Renal and related cancers
Guangdong Pharmaceutical University
2024
Shanghai Tenth People's Hospital
2022-2024
First Affiliated Hospital of Fujian Medical University
2024
Fujian Medical University
2022-2024
Tongji University
2022-2024
Shantou University
2024
Yue Bei People's Hospital
2024
Shanghai Jiao Tong University
2023
Xiamen University
2022
Sichuan University
2022
Ferroptosis is a novel form of iron-dependent cell death and participates in the malignant progression glioblastoma (GBM). Although circular RNAs (circRNAs) are found to play key roles ferroptosis via several mechanisms, including regulating iron metabolism, glutathione lipid peroxidation mitochondrial-related proteins, there many circRNAs need be found, they may become new molecular treatment target GBM.The expression levels circLRFN5, PRRX2 GCH1 were detected by qPCR, western blotting,...
Three new iridium( iii ) complexes were synthesized and characterized. The in vitro anticancer activity of the against A549 cells was investigated, exhibited high efficacy upon irradiation.
Abstract In recent studies, erianin, a natural product isolated from Dendrobium chrysotoxum Lindl, has exhibited notable anticancer properties. Ferroptosis, novel form of programmed cell death, holds potential as strategy to overcome Temozolomide (TMZ) resistance in glioma by inducing ferroptosis TMZ-resistant cells. Here, utilizing various phenotyping experiments, including counting kit-8 (CCK-8) assays, EdU transwell neurosphere formation assays and extreme limiting dilution (ELDA) we...
In this paper, three new iridium(III) complexes: [Ir(piq)
Aim: To study DNA methylation patterns of AluY subfamilies in schizophrenia (SCZ) and bipolar disorder (BPD). Patients & methods: A bisulfite conversion-specific one-label extension method was employed to detect the subfamily levels peripheral blood from 92 SCZ patients, 99 BPD patients controls. Results: Hypermethylation A1 A2 CpG sites hypomethylation A3 site both opposite age-dependent alterations between Conclusion: The differentially altered families suggest role pathogenesis these...
Background.Glioma, the most common primary tumor in central nervous system, originates from glial cells and has a poor prognosis.Objectives.This experimental laboratory study was designed to explore role of epithelial cell adhesion molecule (EpCAM) metastasis glioma.Material methods.Serum samples were collected patients with non-metastatic or metastatic glioma (n = 20 per group), healthy volunteers 8).Exosomes isolated serum morphological characteristics observed under scanning electron...
Some of the fucosylation catalyzed by fucosyltransferase-III mediates epithelial-mesenchymal transition and enhances tumor cell-macrophage signaling, which promotes malignant transforming immune evasion. The aim study was to investigate association between expression clinical outcomes patients with clear-cell renal cell carcinoma after surgery.High associated a greater risk recurrence (p = 0.002) shortened overall survival < 0.001). We then established prognostic nomogram including size,...
Background: The Transforming Growth Factor-Beta (TGF-β) signaling pathway plays a crucial role in the pathogenesis of diseases. This study aimed to identify differentially expressed TGF-β-related genes liver cancer patients and correlate these findings with clinical features immune signatures. Methods: TCGA-STAD LIRI-JP cohorts were utilized for comprehensive analysis TGF-β- related genes. Differential gene expression, functional enrichment, survival analysis, machine learning techniques...
Obliterative bronchiolitis (OB) is the major complication affecting long-term survival of post-lung transplantation patients. In this study, we evaluated efficacy Tk-PQ (a peptide derived from trichosanthin) in alleviating OB a mouse ectopic tracheal transplant model. We found that post-transplantation treatment significant ameliorated symptoms including decreased luminal occlusion, reduced epithelial cells loss and less fibrosis allograft. Further, caused an immune suppressive environment...
Objective To investigate the effects of EEF1 A2 on growth and proliferation human pancreatic cancer cell line SW1990. Methods The gene was introduced into SW1990 by adenovirus vector. were measured MTT. Cell cycle detected flow cytometry rate examined soft agar cloning formation test. Results After EEF1A2 induction, expression EEFA1 A 2 mRNA in increased, value A750 at 72 h 1. 2996 ±0. 2091, number cells 81250, efficiency 14 d 82%, all these parameters significantly higher than those groups...