A5020221977- Osteoarthritis Treatment and Mechanisms
- Knee injuries and reconstruction techniques
- Total Knee Arthroplasty Outcomes
- Orthopaedic implants and arthroplasty
- Bone and Joint Diseases
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Hip disorders and treatments
- Spine and Intervertebral Disc Pathology
- Lower Extremity Biomechanics and Pathologies
- Periodontal Regeneration and Treatments
- MicroRNA in disease regulation
- Hip and Femur Fractures
- Infection Control and Ventilation
- RNA Interference and Gene Delivery
- Autophagy in Disease and Therapy
- Orthopedic Infections and Treatments
- Pediatric Urology and Nephrology Studies
- Advanced biosensing and bioanalysis techniques
- Musculoskeletal pain and rehabilitation
- COVID-19 and healthcare impacts
- Mesenchymal stem cell research
- Trauma and Emergency Care Studies
- RNA modifications and cancer
- COVID-19 epidemiological studies
Changzhi Medical College
2023-2025
Second Hospital of Shanxi Medical University
2025
Shanxi Medical University
2025
Jinan Institute of Quantum Technology
2024
First Affiliated Hospital of Anhui Medical University
2024
Anhui Medical University
2020-2024
Shanghai Tenth People's Hospital
2016-2024
Tongji University
2016-2024
Nanjing Drum Tower Hospital
2024
Nanjing Medical University
2024
PURPOSE: To develop a system for automatic segmentation of the liver from computed tomographic (CT) scans abdomen three-dimensional volume-rendering displays. MATERIALS AND METHODS: An automated was developed, which combined domain knowledge with analysis global histogram, morphologic operators, and parametrically deformable contour model. Boundaries thresholded volume were modified section-by-section by exploiting information adjacent sections. These boundaries refined optimization...
Advanced biomaterial-guided delivery of gene vectors is an emerging and highly attractive therapeutic solution for targeted articular cartilage repair, allowing a controlled minimally invasive in spatiotemporally precise manner, reducing intra-articular vector spread possible loss the product. As far as it known, very first successful vivo application such potent orthotopic large animal model damage reported here. In detail, injectable thermosensitive hydrogel based on poly(ethylene oxide)...
Circular RNAs (circRNAs) play important roles in regulating the radioresistance of esophageal squamous cell carcinoma (ESCC). This study aimed to determine role hsa_circRNA_100367 ESCC.Higher expression and potency endothelial mesenchymal transformation (EMT) was found radioresistant ESCC cells (KYSE-150R) than (KYSE-150). Silencing circRNA_100367 inhibited proliferation migration KYSE-150R cells, decreased β-catenin (an molecule Wnt pathway) cells. Additionally, bound miR-217, miR-217...
Human gliomas are a heterogeneous group of primary malignant brain tumors, which most commonly occur in the central nervous system children and adults. Previous studies have suggested prognostic role matrix metalloproteinase 9 (MMP9) glioma, however, frequency significance protein expression MMP9 glioma remain to be fully elucidated. In present study, was detected by reverse transcription-quantitative polymerase chain reaction (qPCR), western blotting immunohistochemical staining. MTT...
Objectives: To compare the safety and effectiveness of a novel flexible vacuum-assisted ureteral access sheath (FV-UAS) traditional (UAS) in simulating retrograde intrarenal surgery (RIRS). Materials Methods: A manometric model was established porcine kidneys to observe change pressure (IRP) FV-UAS UAS groups at different irrigation fluid velocities 30, 50, 80, 100 mL/min. Establish kidney stone (with 0.2 g, dry, ≤5 mm stones) simulate RIRS. total 20 were randomly numbered from 1 (FV-UAS...
Object Mesenchymal stem cells (MSCs) have been shown to migrate toward tumors, but their distribution pattern in gliomas has not completely portrayed. The primary purpose of the study was assay tropism capacity MSCs gliomas, delineate MSC after systemic injection, and track migration incorporation magnetically labeled using 1.5-T magnetic resonance (MR) imaging. Methods from Fischer 344 rats were colabeled with superparamagnetic iron oxide nanoparticles (SPIO) enhanced green fluorescent...
Esophageal squamous cell carcinoma (ESCC) is a common cancer occurring in males and females worldwide. Accumulating evidence continues to highlight the crucial roles of long non-coding RNAs (lncRNAs) process tumorigenesis. However, regulatory mechanism lncRNAs ESCC remains unclear. The aim this study elucidate role lncRNA Krüppel-like factor 3 antisense RNA 1 (KLF3-AS1) by regulating miR-185-5p KLF3. Initially, spheres with stem cell-like properties were prepared suspension culture,...
Abstract Osteoarthritis (OA) is characterized by critical alterations of the subchondral bone microstructure, besides well‐known cartilaginous changes. Clinical computed tomography (CT) detection quantitative 3D microstructural parameters applied to monitor changes structure in different stages human OA and compared with micro‐CT, gold standard. Determination clinical CT (287 µm resolution) key tibial plateaus mild‐to‐moderate severe reveals strong correlations micro‐CT (35 µm), high inter‐...
OBJECTIVE We sought to explore the dual-targeted antitumor effects of membrane-spanned, tumor necrosis factor-related, apoptosis-inducing ligand (TRAIL)-engineered human mesenchymal stem cells (hMSCs) against brainstem gliomas. METHODS The migration capacity hMSCs toward gliomas was studied by Transwell system in vitro and intravenous injection glioma-bearing mice vivo. MSCs were engineered with native full-length TRAIL (hTRAIL) a recombinant adeno-associated virus (rAAV) vector...
This study investigated the effect of hypoxia at high altitude on semen quality and serum reproductive hormone levels in male adults. A total 52 soldiers were enrolled this cohort study. They exposed to (5380 m) for 12 months when undergoing a service. After exposure, they followed up 6 months. The samples peripheral blood collected 1 month before exposure (M0), (M6), (M12), after (M18). was assessed with computer-assisted analysis system, hormones, including prolactin (PRL), luteinizing...
Early osteoarthritis induced in a clinically relevant ovine model progresses highly specific spatiotemporal pattern resembling human OA.
Follistatin-like 3 (FSTL3) binds and inactivates activin, a growth factor with cell differentiation. Previous studies reported that it is overexpressed in invasive breast cancers, its expression function non-small lung cancer (NSCLC) remain unclear.Immunohistochemistry was employed to probe the of FSTL3 NSCLC tissues. Real-time PCR (RT-PCR) applied detect lncRNA DSCAM-AS1 miR-122-5p. A549 cells H1299 were used as models. The biological influence on studied using CCK-8 assay, wound healing...
The origin recognition complex (ORC), a six-subunit DNA-binding complex, participates in DNA replication cancer cells. Specifically prostate cancers, ORC the androgen receptor (AR) regulated genomic amplification and tumor proliferation throughout entire cell cycle. Of note, ORC6, smallest subunit of ORC, has been reported to be dysregulated some types cancers (including cancer), however, its prognostic immunological significances remain yet elucidated.In current study, we comprehensively...
Rationale: For traumatic upper limb amputees, the prohibitive cost of a custom-made prosthesis brings an insufferable financial burden for their families in developing countries. Three-dimensional (3D) printing allows creating affordable, lightweight, customized, and well-fitting prosthesis, especially growing children. Patient concerns: We presented case 8-year-old boy, who suffered right wrist amputation as result mincing machine accident. The patient was immediately sent to emergency...
Abstract Background The supercapsular percutaneously-assisted total hip arthroplasty (SuperPath) was proposed to be minimally invasive and tissue sparing with possible superior postoperative outcomes traditional approaches of (THA). Here, we compared the short-term staged THA SuperPath or through posterolateral approach (PLA) for bilateral osteonecrosis femoral head (ONFH). Methods Patients late-stage ONFH were prospectively recruited from our department March 2017 2018. Staged THAs one side...