A5027140606- Sperm and Testicular Function
- Reproductive Biology and Fertility
- Ovarian function and disorders
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Reproductive System and Pregnancy
- Reproductive Health and Technologies
- Reproductive tract infections research
- Assisted Reproductive Technology and Twin Pregnancy
- Molecular Biology Techniques and Applications
- Folate and B Vitamins Research
- Chromosomal and Genetic Variations
- Sexual function and dysfunction studies
- Renal and related cancers
- COVID-19 Impact on Reproduction
- Estrogen and related hormone effects
- Hormonal and reproductive studies
- Climate Change and Health Impacts
- Potato Plant Research
- Animal Genetics and Reproduction
- CRISPR and Genetic Engineering
- Urological Disorders and Treatments
- Sexual Differentiation and Disorders
- Terahertz technology and applications
- Seedling growth and survival studies
- Near-Field Optical Microscopy
University of Science and Technology of China
2018-2025
Anhui Provincial Hospital
2022
Center for Excellence in Molecular Cell Science
2022
Taipei Municipal YangMing Hospital
2020
Nanjing Medical University
2017-2019
Jinan University
2013-2018
Guangdong Provincial People's Hospital
2015
The novel coronavirus disease (COVID-19) pandemic is emerging as a global health threat and shows higher risk for men than women. Thus far, the studies on andrological consequences of COVID-19 are limited. To ascertain sperm parameters after recovery, we recruited 41 reproductive-aged male patients who had recovered from COVID-19, analyzed their semen serum sex hormones at median time 56 days hospital discharge. For longitudinal analysis, second sampling was obtained 22 interval 29 first...
Abstract Iron oxide nanoparticles (IONPs)-based contrast agents are widely used for T 2 -weighted magnetic resonance imaging (MRI) in clinical diagnosis, highlighting the necessity and importance to evaluate their potential systematic toxicities. Although a few previous studies have documented toxicity concerns of IONPs major organs, limited data available on reproductive caused by IONPs, especially when administrated via intravenous injection mimic use MRI agents. Our study aimed determine...
Abnormal body mass index (BMI) is associated with an increased risk of erectile dysfunction (ED). However, the relationship between different BMI categories and levels ED severity remains unclear. In current study, 878 men from andrology clinic in Central China were recruited. Erectile function was assessed by International Index Function (IIEF) scores. Questionnaires included questions about demographic characteristics (age, height, weight, educational status), lifestyle habits (drinking,...
Transcription factors of the Sox protein family contain a DNA-binding HMG box and are key regulators progenitor cell fate. Here, we report that expression Sox30 is restricted to meiotic spermatocytes postmeiotic haploids. mutant males sterile due spermiogenic arrest at early round spermatid stage. Specifically, in absence Sox30, proacrosomic vesicles fail form single acrosomal organelle, spermatids step 2-3. Although most progress through meiosis, accumulation diplotene indicates delayed or...
Several male factors have been reported to play a role in recurrent pregnancy loss (RPL). The aim of this study is explore the relationship between semen parameters, sperm DNA fragmentation index (DFI) and RPL. A total 1485 participants were recruited from university hospital April 2020 August 2022. Six hundred thirtyfour men couples with RPL assigned case group, while 851 couple without who underwent fertile evaluation control group. Semen parameters including fragmentation, assessed. No...
Objective Abstinence time has been associated with semen quality, but the results remain controversial. Methods This study recruited 3052 men undergoing fertility evaluation. (AT) was categorized as short (0-1 day), WHO-recommended (2-7 days) and long (>7 days). Semen parameters including volume, sperm concentration, progressive motility, total motility count (TMSC), morphology DNA fragmentation index were assessed for their association AT. Results Short AT significantly lower volume...
Multiple morphological abnormalities of the sperm flagella (MMAF) is a severe form asthenozoospermia categorized by immotile spermatozoa with abnormal in ejaculate. Whole-exome sequencing (WES) used to detect pathogenic variants patients MMAF. In this study, novel homozygous frameshift variant (c.6158_6159insT) dynein axonemal heavy chain 8 (DNAH8) from two infertile brothers MMAF consanguineous Pakistani family was identified WES. Reverse transcription-polymerase reaction (RT-PCR) confirmed...
Impaired fertility and low sperm quality are the global health problem with high attention. It has been noted that inflammation may impact by affecting testicular spermatogenesis. Cyanidin-3-O-glucoside is a natural functional pigment various benefits. Nevertheless, studies on mechanism which C3G protects male reproduction in mice ulcerative colitis remain scarce. The purpose of this study to illustrate potential for improving impaired caused colitis. A DSS-induced model was applied assess...
3-Monochloropropane-1,2-diol (3-MCPD) is a well-known food processing contaminant that has been shown to impede the male reproductive function. However, its mechanism of action remains be elucidated. In this study, effects 3-MCPD on progesterone production were investigated using R2C Leydig cells. caused concentration-dependent inhibition cell viability at IC25, IC50, and IC75 levels 1.027, 1.802, 3.160 mM, respectively. Single gel/comet assay atomic force microscopy showed significantly...
Context. Polycystic ovary syndrome (PCOS) is a gynecological endocrine disease, and approximately 60% of patients with PCOS have different degrees insulin resistance (IR). The regulatory role metabolic networks in human follicular fluid (FF) related to IR remains unclear. Aims. To explore the effect on metabolism by analyzing changes FF metabolites who are undergoing assisted reproductive technology based metabonomic platform ultraperformance gas chromatography coupled mass spectrometry...
What is the physiological role of Rictor in spermatogenic cells? Germline expression regulates spermatogonial differentiation and has an essential coordinating germ cells Sertoli maintaining intact cell–cell adhesion dynamics cytoskeleton-based architecture seminiferous epithelium. The mechanistic target rapamycin (mTOR) resides its functions as catalytic subunits structurally functionally distinct mTORC1 mTORC2 complexes. In mammalian testis, stem cell self-renewal differentiation, whereas...
Alcohol consumption has commonly been associated with semen parameters. However, the association between alcohol intake and parameters in primary secondary infertile men remains unclear. In this study, 776 from China were grouped according to intake: abstainers, moderate drinkers (<9 units/week, up approximately 100 g of ethanol) heavy (≥9 units/week). Semen parameters, including volume, sperm concentration, total count, progressive motility normal morphology investigated. other lifestyle...
In Brief Background The presence of persistent Chlamydia trachomatis infection after treatment does not always correlate with in vitro susceptibility testing. Methods minimum inhibitory concentration (MIC) and minimal bactericidal (MBC) azithromycin, clarithromycin, roxithromycin, doxycycline, tetracycline, ofloxacin, penicillin were tested against 61 clinical isolates C. on 6 serovars, the MIC/MBC azithromycin ofloxacin at different points time antibiotic administration to infected...
Rapamycin is a clinically important drug that used in transplantation and cancer therapy but which causes number of side effects, including male infertility. Its canonical target, mammalian target rapamycin complex 1 (mTORC1), plays key role metabolism binds chromatin; however, its precise the germline has not been elucidated. Here, we inactivate core component, Raptor, to show mTORC1 function critical for meiosis inactivation sex chromosomes. Disruption Raptor gene impairs chromosomal...
In vitro fertilization-embryo transfer (IVF-ET) technology make it possible for infertile couples to conceive a baby successfully. Nevertheless, IVF-ET does not guarantee success. Frozen embryo (FET) is an important supplement IVF-ET. Many factors are correlated with the outcome of FET which unpredictable. Machine learning field study that predict various outcomes by defining data attributes and using relevant calculation algorithms. algorithm has been widely used in clinical research. The...
This study aims to compare the prevalence of sexually transmitted infections (STIs) with semen quality in men from couples primary and secondary infertility. Semen samples were collected 133 who requested fertility evaluation. Seminal tract infection Ureaplasma spp. (UU), Mycoplasma hominis (MH), genitalium (MG), Chlamydia trachomatis (CT), Neisseria gonorrhoeae (NG), herpes simplex virus-2 (HSV-2) was assessed by PCR-based diagnostic assays. Among all patients, STIs higher infertility than...