A5101975554- Inflammatory Biomarkers in Disease Prognosis
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Microplastics and Plastic Pollution
- Ferroptosis and cancer prognosis
- Trauma and Emergency Care Studies
- Bone and Dental Protein Studies
- Pharmaceutical and Antibiotic Environmental Impacts
- Lung Cancer Treatments and Mutations
- Ubiquitin and proteasome pathways
- Bioinformatics and Genomic Networks
- CAR-T cell therapy research
- Kidney Stones and Urolithiasis Treatments
- Biochemical and Molecular Research
- Cancer Research and Treatments
- RNA modifications and cancer
- Constructed Wetlands for Wastewater Treatment
- Prostate Cancer Diagnosis and Treatment
- Chromosomal and Genetic Variations
- Blood transfusion and management
- Acute Ischemic Stroke Management
- Therapeutic Uses of Natural Elements
- Reproductive Biology and Fertility
- Immune Cell Function and Interaction
- Erythropoietin and Anemia Treatment
- Animal Genetics and Reproduction
First Affiliated Hospital Zhejiang University
2025
South China Agricultural University
2025
Capital Medical University
2024
Beijing Royal Integrative Medicine Hospital
2024
Fudan University
2024
Fudan University Shanghai Cancer Center
2024
Huazhong University of Science and Technology
2015-2023
Xuzhou Medical College
2016-2023
Second People’s Hospital of Huai’an
2016-2023
Tongji Hospital
2015-2023
Sepsis-associated encephalopathy (SAE) often manifests in severe diffuse cerebral dysfunction due to an aberrant systemic immune response infection. The underlying pathophysiology of SAE is not entirely understood but likely a multifactorial process that involves disruption cell death mechanism. Ferroptosis novel form programmed characterized by iron accumulation and lipid peroxidation, leading inflammatory cascade glutamate release. We hypothesized ferroptosis involved the...
Transcription factors of the Sox protein family contain a DNA-binding HMG box and are key regulators progenitor cell fate. Here, we report that expression Sox30 is restricted to meiotic spermatocytes postmeiotic haploids. mutant males sterile due spermiogenic arrest at early round spermatid stage. Specifically, in absence Sox30, proacrosomic vesicles fail form single acrosomal organelle, spermatids step 2-3. Although most progress through meiosis, accumulation diplotene indicates delayed or...
•First pilot trial of oncolytic virus and programmed cell death protein 1 inhibitors in refractory HCC.•H101 injections show promise reversing immune checkpoint inhibitor resistance, extending OS PR cases.•Dynamic neutrophil-to-lymphocyte ratio changes during OV pretreatment may predict outcomes. BackgroundH101, an innovative adenovirus, has shown potential modifying the tumor microenvironment from immunologically 'cold' to 'hot'. When combined with nivolumab, a inhibitor, this synergy offer...
Rheumatoid arthritis (RA) is a debilitating systemic autoimmune disorder that significantly impairs quality of life. To elucidate the molecular alterations in RA progression, we performed comprehensive super-omics analyses on synovial tissues from patients with joint trauma, arthritis, and RA. These included transcriptomics, proteomics, metabolomics, microbiomics, fourteen PTMs (phosphorylation, acetylation, lactylation, O-GlcNAc glycosylation, arginine monomethylation, lysine dimethylation,...
The morbidity of bone metastasis (BM) from colorectal cancer (CRC) is increasing more than ever; however, insufficient research on BM CRC leads to reduced awareness the issue. Therefore, aim this study was evaluate clinical features and prognostic risk factors patients with BM. Clinical data were retrospectively analyzed for a total 242 Of BM, 52 (21.5 %) had alone (BMA) 190 (78.5 both visceral (BM&VM). median survival time (MST) after diagnosis in all 15.6 months (95 % confidence interval...
The systemic inflammation score (SIS) based on the albumin (Alb) level and lymphocyte-to-monocyte ratio (LMR), has been associated with survival in some cancers. However, its prognostic role prostate cancer (PCa) remains unclear.The associations between SIS clinicopathological features of PCa were evaluated. correlations overall (OS) progression-free (PFS) assessed using Kaplan-Meier analysis Log rank test. Univariate multivariate Cox analyses conducted to determine factors for PCa. Hazard...
Osteopontin (OPN) has an important role in urolithiasis. However, few studies have explored the association between OPN genetic variants and urolithiasis risk. In present study, three single‑nucleotide polymorphisms (SNPs) (rs28357094, rs11439060 rs11730582) located on promoter of were genotyped a total 480 individuals, including 230 nephrolithiasis patients 250 matched healthy controls, associations these SNPs risk different models was assessed. No significant differences identified...
Mechanistic target of rapamycin (mTOR) controls cell growth and metabolism in response to environmental metabolic signals. Rapamycin robustly extends the lifespan mammals has clinical relevance organ transplantation cancer therapy but side effects include male infertility. Here, we report that chronic treatment causes spermatogenic arrest adult mice due defects sex body formation meiotic chromosome inactivation (MSCI). Many chromosome-linked genes were up-regulated isolated pachytene...
Abstract Objective: Our study aimed to explore the clinical predict factors and establish a simple concise model early identify patients at high risk of venous thromboembolism (VTE) after traumatic brain injury (TBI). Methods: We performed retrospective 685 with TBI admitted our trauma center from April 2018 2021. The experimental group were consisted which diagnosed VTE during hospital, control randomly selected rest ratio 1:1. statistical analysis predictors in patients, established...
Objective To evaluate the efficacy and safety of DA-EPOCH-R protocol for patients with B-cell non-hodgkin lymphoma (NHL). Methods 43 NHL received protocol, their adverse reactions were analyzed. Results 43 a total 203 cycles chemotherapy median cycle was 6 (2-8 cycles). 32 (74.4 %) achieved complete remission (CR) after 2-4 chemotherapy. A further analysis found that age ≤60 years > 60 years, stageⅠ/Ⅱ stage Ⅲ/Ⅳ, germinal center (GCB), non-GCB, double expression (DEL) non-DEL had...