A5021623396- Orthopaedic implants and arthroplasty
- Bone and Joint Diseases
- Orthopedic Infections and Treatments
- Hip disorders and treatments
- Bone Metabolism and Diseases
- Total Knee Arthroplasty Outcomes
- Osteoarthritis Treatment and Mechanisms
- Bone health and treatments
- MicroRNA in disease regulation
- Spine and Intervertebral Disc Pathology
- Scoliosis diagnosis and treatment
- Hip and Femur Fractures
- Knee injuries and reconstruction techniques
- Venous Thromboembolism Diagnosis and Management
- Inflammatory mediators and NSAID effects
- Spinal Fractures and Fixation Techniques
- Cancer-related molecular mechanisms research
- Mitochondrial Function and Pathology
- NF-κB Signaling Pathways
- Single-cell and spatial transcriptomics
- Diabetic Foot Ulcer Assessment and Management
- Circular RNAs in diseases
- Proteoglycans and glycosaminoglycans research
- Nanoparticles: synthesis and applications
- Surgical Sutures and Adhesives
First Affiliated Hospital Zhejiang University
2020-2025
Zhejiang University
2020-2024
Xuzhou Medical College
2012-2022
Ratio
2018
Creative Commons
2018
Affiliated Hospital of Xuzhou Medical College
2014-2016
Corticosteroid use has been implicated in the development of osteonecrosis femoral head (ONFH). The exact mechanism and predisposing factors such as age, gender, dosage, type combination steroid treatment remain controversial. Between March July 2003, a total 539 patients with severe acute respiratory syndrome (SARS) were treated five different types steroid. There 129 men (24%) 410 women (76%) mean age 33.7 years (21 to 59). Routine screening was undertaken radiographs, MRI and/or CT...
Rheumatoid arthritis (RA) is a debilitating systemic autoimmune disorder that significantly impairs quality of life. To elucidate the molecular alterations in RA progression, we performed comprehensive super-omics analyses on synovial tissues from patients with joint trauma, arthritis, and RA. These included transcriptomics, proteomics, metabolomics, microbiomics, fourteen PTMs (phosphorylation, acetylation, lactylation, O-GlcNAc glycosylation, arginine monomethylation, lysine dimethylation,...
Background Leg length discrepancy (LLD) after total hip arthroplasty (THA) is a clinical entity that deteriorates outcomes and patients’ satisfaction. Few articles have compared LLD THA by different surgical approaches. Methods A of 358 consecutive patients who underwent primary between January 2016 November 2018 were retrospectively reviewed. All 4 surgeons performed through both direct anterior approach (DAA) posterior lateral (PLA). The outcome measurement was LLD. measured on...
Growing evidence indicates that microRNAs (miRNA) play a critical role in the pathogenesis of OA, and overexpressing or silencing miRNA expression OA models can contribute to development miRNA-based therapeutics. The objective this study was determine whether intra-articular injection inhibit progression.
In the human body, joint cartilage is of great importance. It has long been a big therapeutic problem to fix lesions as it appears due different conditions. Recent stories have shown that replacement process must delay extracellular (ECM) deterioration and modulate host's inflammation response. For reconstruction articular cartilage, drug-loaded injectable hydrogels were developed. This hydrogel could retain chondrocyte phenotype, but inflammatory reaction also be controlled. The bioglass...
The aryl hydrocarbon receptor (AhR) pathway may play an important role in the regulation of osteoclasts, but there are still conflicting studies on this aspect, and specific mechanism action has not been fully elucidated. Therefore, we conducted study to find a drug treat osteoporosis that targets AhR. We found StemRegenin 1 inhibited RANKL-induced osteoclastogenesis concentration-dependent time-dependent manner. Through further experiments, SR1 can inhibit nuclear transcription AhR c-src...
Objective: To explore the clinical characteristics of osteonecrosis femoral head (ONFH) induced by steroids. Methods: From January 2000 to October 2009, 497 hips in 270 cases ONFH steroids were studied. A questionnaire was administered when patients admitted; questions concerned underlying disease, duration steroid usage, total dosage steroid, incubation period (time interval between commencement therapy and onset pain), severity pain, location initial complaint, primary diagnosis, time lag...
Background: Venous thromboembolism (VTE) is a well-documented complication in patients with lower limb fractures, but management guidelines for its prevention isolated foot and ankle fracture are conflicting. The aim of this study was to conduct multicenter, prospective cohort define the prevalence VTE fractures determine whether routine prophylaxis necessary these patients. Methods: In double-blind, placebo-controlled study, consecutive 3 hospitals who met our criteria were enrolled. After...
Total hip arthroplasty (THA) with failure of tantalum rod implant for osteonecrosis the femoral head (ONFH) will be only choice patients. However,it remains unknown whether implantation has an adverse effect on survival time implants following conversion to THA. The aim this study was retrospectively evaluate clinical and radiographic outcomes THA in patients who were previously treated a rod. This included 31 (39 hips), underwent due core decompression implanted Among these patients, 26...
Photoluminescent nanomaterials have been widely employed in several biological applications both vitro and vivo. For the first time, we report a novel application of sour apple-derived photoluminescent carbon dots (PCDs) for reducing ultra-high molecular weight polyethylene (UHMWPE) wear particle-induced osteolysis using mouse calvarial model. Generally, aseptic prosthetic loosening seems to be significant postoperative problem artificial joints replacement, which is mainly contributed by...
Abstract Background Osteoarthritis (OA) is a prevalent and debilitating condition, that is, directly associated with cholesterol metabolism. Nevertheless, the molecular mechanisms of OA remain largely unknown, role in this process has not been thoroughly investigated. This study aimed to investigate novel circular RNA, circARPC1B relationship between progression. Methods We measured total (TC) levels synovial fluid patients or without determine diagnostic OA. The effects were explored human...
As an essential step of total hip arthroplasty (THA), effective and secure skin closure technique after primary THA is important. Metallic staples subcuticular suture are the 2 common techniques for closure. However, which optimal skin-closure method remains unclear. The purpose this prospective randomised clinical study was to compare outcomes costs between techniques.In study, 165 patients who underwent unilateral through a posterolateral approach from August 2014 May 2015 were included....
To explore the clinical characteristics of steroid-associated osteonecrosis femoral head (ONFH) presenting initially normal magnetic resonance imaging (MRI) results. This retrospective study examined data from 23 cases that suffered ONFH but presented a image at first MRI examination after corticosteroid therapy June 2005 to December 2013. Data on protopathy, age, sex, time pain onset, examination, and initial diagnosis were collected analyzed. Average steroid was 45.7 ± 25.5 days (range,...
Pigment epithelial-derived factor (PEDF) is known as a widely expressed multifunctional secreted glycoprotein whose biological actions are cell-type dependent. Recent studies demonstrated that PEDF displays cytoprotective activity in several cell types. However, it remains unknown whether involved glucocorticoid-induced osteoblast death. The aim of this study was to examine the role survival response dexamethasone, an active glucocorticoid analogue, and explore underlying mechanism. In...
Abstract Background The aim of the present study was to investigate clinical and radiological outcomes autologous tricortical iliac grafting performed through a window created at femoral head without suturing opened articular cartilage for treatment osteonecrosis (ONFH), called modified trapdoor procedures. Materials methods A total 59 consecutive patients (67 hips; 36 males 23 females) with ONFH were included in this study, which conducted from April 2009 March 2012. Patients’ age ranged 27...
Abstract Background Tetrandrine, a bisbenzylisoquinoline (BBI) alkaloid extracted from Stephania tetrandra (S. Moore), and is widely used in several diseases such as tuberculosis, hyperglycemia, malaria, tumors. Tetrandrine was recently shown to prevent bone loss ovariectomized mice. However, the specific mechanism underlying osteoclastogenesis inhibition remains unclear. Methods Tetrandrine’s cytotoxicity cells determined using Cell Counting Kit-8 assay. Tartrate-resistant acid phosphatase...
Ultra-high molecular weight polyethylene (UHMWPE) has been widely used in large joint replacement. Osteolysis induced by the UHMWPE wear particles is one of main causes replacement failure. This study aims to elucidate whether dendritic cells play a role particle-induced osteolysis. An vitro Raw 264.7 and DC 2.4 coculture system was employed examine effects on inflammatory osteoclastogenic responses toward particles. The expression cytokines, NF-κB, osteoclast marker genes analyzed ELISA,...