A5101474767- Neurogenesis and neuroplasticity mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Methane Hydrates and Related Phenomena
- Biochemical and Molecular Research
- Memory and Neural Mechanisms
- Neuroscience and Neuropharmacology Research
- Sphingolipid Metabolism and Signaling
- Peptidase Inhibition and Analysis
- Lipid Membrane Structure and Behavior
- Water Quality and Pollution Assessment
- Hydrology and Watershed Management Studies
- Cancer, Hypoxia, and Metabolism
- Ubiquitin and proteasome pathways
- CO2 Sequestration and Geologic Interactions
- Endoplasmic Reticulum Stress and Disease
- Diabetes Treatment and Management
- RNA Research and Splicing
- Soil and Water Nutrient Dynamics
- Environmental and Agricultural Sciences
- Water resources management and optimization
- Spacecraft and Cryogenic Technologies
- Bioinformatics and Genomic Networks
- PARP inhibition in cancer therapy
- Child Nutrition and Water Access
- DNA Repair Mechanisms
State Key Laboratory of Biotherapy
2019-2023
Sichuan University
2019-2023
West China Hospital of Sichuan University
2020-2023
Central Hospital of Zibo
2023
Chengdu Center for Disease Control and Prevention
2022
Chinese Academy of Sciences
2002
Guangzhou Institute of Energy Conversion
2001
Introduction: Serine hydroxymethyltransferase 2 (SHMT2) plays a critical role in serine-glycine metabolism to drive cancer cell proliferation. However, the nonmetabolic function of SHMT2 tumorigenesis, especially human colorectal (CRC) progression, remains largely unclear. Methods: expression CRC cells was identified by western blot and immunofluorescence assay. The proliferation, migration, invasion after knockdown or overexpression were explored through vitro vivo assays....
Human dihydroorotate dehydrogenase (hDHODH) is an attractive target for cancer therapy. Based on its crystal structure, we designed and synthesized a focused compound library containing the structural moiety of 1,4-benzoquinone, which possesses reactive oxygen species (ROS) induction capacity. Compound 3s with naphtho[2,3-d][1,2,3]triazole-4,9-dione scaffold exhibited inhibitory activity against hDHODH. Further optimization led to compounds 11k 11l, inhibited hDHODH IC50 values 9 4.5 nM,...
Abstract Poly (ADP-ribose) polymerase inhibitors (PARPi) are selectively active in ovarian cancer (OC) with homologous recombination (HR) deficiency (HRD) caused by mutations BRCA1/2 and other DNA repair pathway members. We sought molecular targeted therapy that induce HRD HR-proficient cells to synthetic lethality PARPi extend the utility of PARPi. Here, we demonstrate lysine-specific demethylase 1 (LSD1) is an important regulator for OC. Importantly, genetic depletion or pharmacological...
Maintaining water quantity and quality are two problems that occur during resource development. Considering the reciprocal relationship, threshold of development urgently needs to be evaluated guarantee environmental function. In this study, resources carrying capacity (WRECC) evaluation method was proposed based on dualistic cycle analysis. Nine indicators from 4 aspects, including utilization proportion, use efficiency, pollutant treatment river flow, mutual coupling in processes, were...
The development, persistence and relapse of drug addiction require memory that generally develops with administration-paired contextual stimuli. Adult hippocampal neurogenesis (AHN) contributes to cocaine formation; however, the underlying mechanism remains unclear. Male mice expression Tau was significantly decreased during cocaine-associated formation. Genetic overexpression four microtubule-binding repeats (4R Tau) in hippocampus disrupted by suppressing AHN. Furthermore, 4R directly...
Cefepime exhibits a broad spectrum of antimicrobial activity and thus is widely used treatment for severe bacterial infections. Adverse effects on the central nervous system (CNS) have been reported in patients treated with cefepime. Current explanation adverse neurobehavioral effect cefepime mainly attributed to its ability cross blood-brain barrier competitively bind GABAergic receptor; however, underlying mechanism largely unknown. In this study, mice were intraperitoneally administered...
The expression of linear DNA sequence is precisely regulated by the three-dimensional (3D) architecture chromatin. Morphine-induced aberrant gene networks neurons have been extensively investigated; however, how morphine impacts 3D genomic still unknown. Here, we applied digestion-ligation-only high-throughput chromosome conformation capture (DLO Hi-C) technology to investigate effects on chromatin primate cortical neurons. After receiving continuous administration for 90 days rhesus...
Abstract The expression of linear DNA sequences is precisely regulated by the three–dimensional (3D) architecture chromatin. Morphine-induced aberrant gene networks neurons have been extensively investigated; however, how morphine impacts 3D genomic neuorns still unknown. Here, we applied digestion-ligation-only high-throughput chromosome conformation capture (DLO Hi-C) technology to investigate affection on chromatin primate cortical neurons. After receiving continuous administration for 90...
Abstract Background: Drug memory that generally develops with drug-paired contextual stimuli and drug administration is critical for the development, persistence relapse of addiction. Previous studies have suggested adult hippocampal neurogenesis (AHN) plays a role in cocaine formation; however, underlying mechanism not fully understood. Methods: Conditioned place preference (CPP), self-administration locomotor activity were used to investigate Tau cocaine-associated formation....
The expression of linear DNA sequences is precisely regulated by the three-dimensional (3D) architecture chromatin. Morphine-induced aberrant gene networks neurons have been extensively investigated; however, how morphine impacts 3D genomic still unknown. Here, digestion-ligation-only high-throughput chromosome conformation capture technology was applied to investigate chromatin brain cortical in non-human primates treated with for 90 days continuously. We discovered that dramatically...
In order to evaluate the effectiveness of water pollution control policies in upper Tuojiang River Basin (UTRB) during different periods, seasonal trend decomposition using loess (STL), principal component analysis (PCA), factor (FA), absolute score (APCS) and multiple linear regression (MLR) were applied. An APCS/MLR-based estimation method for source contribution variation concentration was established analyze changes structures over time. A monthly dataset from 2006 2020 9 quality...
Abstract Cefepime exhibits a broad spectrum of antimicrobial activity and thus is widely used for severe bacterial infection. Adverse effects on the central nervous system (CNS) have been reported in patients treated with cefepime. Current explanation neurobehavioral effect cefepime mainly attributes to its ability across blood-brain barrier competitively bind GABAergic receptor; however, underlying mechanism largely unknown. In this study, mice were intraperitoneally administered 80 mg/kg...