A5115601699- Nanoplatforms for cancer theranostics
- Luminescence and Fluorescent Materials
- Molecular Sensors and Ion Detection
- Advanced biosensing and bioanalysis techniques
- Catalytic C–H Functionalization Methods
- Metal complexes synthesis and properties
- DNA and Nucleic Acid Chemistry
- Supramolecular Self-Assembly in Materials
- Sulfur Compounds in Biology
- Asymmetric Hydrogenation and Catalysis
- Mosquito-borne diseases and control
- Autophagy in Disease and Therapy
- Photochromic and Fluorescence Chemistry
- Catalytic Cross-Coupling Reactions
- Lipid Membrane Structure and Behavior
- Ferrocene Chemistry and Applications
- RNA modifications and cancer
- Photodynamic Therapy Research Studies
- Toxoplasma gondii Research Studies
- Biosensors and Analytical Detection
- Cancer, Hypoxia, and Metabolism
- Sulfur-Based Synthesis Techniques
- SARS-CoV-2 detection and testing
- Cytomegalovirus and herpesvirus research
- Epigenetics and DNA Methylation
Sichuan University
2009-2024
Chengdu University
2017-2020
University of Virginia
2010
Significant progress has been accomplished in directed C–H functionalization through the use of earth-abundant and inexpensive first-row transition metals.
An optically active BINOL-terpyridine based Cu(II) complex (R)-2 was prepared. Sonication of in CHCl(3) led to the formation a stable gel. The interaction this gel with chiral amino alcohols studied. It found that (S)-phenylglycinol (0.10 equiv) could break network (3.75% w/v, g/mL) cause collapsing but (R)-phenylglycinol not. Similar enantioselective also observed (R)- and (S)-1-amino-2-propanol. This study demonstrates molecular gels are potentially useful for visual discrimination....
A new series of purine-based derivatives with easy availability and colour tunability were synthesized could be used for lipid droplet imaging.
Abstract Organic molecules with second near‐infrared (NIR‐II, 1000–1700 nm) emission have significant advantages over NIR‐I (600–900 dyes, and been widely used as phototheranostic agents (PTAs) fluorescent probes. However, the two biggest challenges for such reagents are improving photothermal conversion efficiency (PCE), simplifying tedious synthetic procedures. Herein, different from traditional NIR skeleton, first time, it develops novel dibenzofulvene‐based NIR‐II PTAs via D‐π‐A concept...
High-performance fluorescent probes stand as indispensable tools in fluorescence-guided imaging, and are crucial for precise delineation of focal tissue while minimizing unnecessary removal healthy tissue. Herein, machine-learning-assisted strategy to investigate the current available xanthene dyes is first proposed, a quantitative prediction model guide rational synthesis novel molecules with desired pH responsivity constructed. Two Si─rhodamine derivatives successfully achieved...
Electrochemical intermolecular C–N formation for the synthesis of imidazopyridines.
Photodynamic therapy (PDT) has emerged as a promising approach for tumor treatment. However, traditional type II PDT faces limitations due to its oxygen-dependent nature. Type-I photosensitizers (PSs) exhibit superiority over conventional type-II PSs owing their diminished oxygen dependence. Nevertheless, designing effective type-I remains significant challenge. In this work, we provide novel strategy tune the mechanism of an excited photosensitizer through aryl substituent engineering....
Non-invasive dynamic tracking of lysosomes and their interactions with other organelles is important for the study lysosomal function related diseases. However, many fluorescent dyes developed so far to target cannot be used monitor these processes due high concentrations required imaging, long cell penetration times, non-ideal photostability. In this regard, we synthesized three targeting probes large Stokes shifts, good stability, brightness. The Q-P-ARh dye, by us first time, can stain at...
Combining γ-glutamyl transpeptidase and pH dual-responsive sites, an “and” logic gate-based NIR fluorescent probe Si-NH2-Glu was developed for orthotopic breast tumor imaging.
Accurate detection of target analytes and generation high-fidelity fluorescence signals are particularly critical in life sciences clinical diagnostics. However, the majority current NIR-I fluorescent probes vulnerable to pH effects resulting signal distortion. In this work, a series fluorescence-tunable pH-independent reported by combining optically tunable groups unsymmetric Si-rhodamines introducing methoxy instead spiro ring on benzene at position 9. To validate concept, leucine...
Abstract Photodynamic therapy (PDT) presents a promising approach for combating periodontitis, an infectious disease triggered by bacteria. However, the hypoxic environment within periodontal pockets poses challenges PDT efficacy. In this study, novel purine‐based C^N ligands are utilized to develop Ir(III) complexes with enhanced reactive oxygen species (ROS) generation capacity periodontitis treatment. The type I/II performance of is greatly purine ligands, which leads potent bactericidal...
Enriching the palette of high-performance fluorescent dyes is vital to support frontier biomedical imaging. Although various rhodamine skeletons remain premier type small-molecule fluorophores due apparent high brightness and flexible modifiability, they still suffer from inherent defect small Stokes shift nonideal fluorescence imaging signal-to-background ratio. Especially, rising class dyes, sulfone-substituted xanthone, exhibits great potential, but low chemical stability also pointed out...
Activatable probes with a higher signal-to-background ratio and accuracy are essential for monitoring liver cancer as well intraoperative fluorescence navigation. However, the presence of only one biomarker is usually not sufficient to meet high requirement in surveillance, leading risk misdiagnosis. In this work, dual-locked activation response probe,
The introduction of amines onto aromatics without metal catalysts and chemical oxidants is synthetically challenging. Herein, we report the first example an electrochemical cross-dehydrogenative aromatization (ECDA) reaction saturated cyclohexanones to construct anilines additional oxidants. This exhibits a broad scope including heterocyclic ketones, affording variety aromatic with various functionalities, shows great potential in synthesis biologically active compounds.
An Si–rhodamine derivative with a large Stokes shift and high fluorescence brightness was applied to distinguish normal serum from of COVID-19 patients.
Abstract pH is spatiotemporal variable dynamically in physiological and pathological processes, the tiny changes can result completely different processes. However, major drawbacks of conventional pH‐activatable probes are their large acid‐base transition width challenge to adjust pKa suitable for various application. In response these issues, a novel approach proposed realize sensitive general strategy construct multicolor pKa‐tunable xanthene‐based platform. probes, narrowest range just 1...
Abstract Phototheranostics integrates light‐based diagnostic techniques with therapeutic interventions, offering a non‐invasive, precise, and swift approach for both disease detection treatment. The efficacy of this hinges on the multimodal imaging potential photothermal conversion efficiency (PCE) phototheranostic agents (PTAs). Despite promise, crafting multifunctional organic small molecules brims challenges. In research, four innovative xanthene‐derived PTAs are synthesized by...
A novel and efficient method to synthesize rigid bis-coumarins based on the dimerization of coumarinyl aldehydes was developed.
A simple assembly system of phospholipid bilayer and probes<italic>via</italic>electrostatic hydrophobic interactions was constructed.
Aqueous Wittig reactions in nucleic acids under mild conditions for fluorogenic identification of 5fC and single-base resolution sequencing were studied.
A simple method was established for the determination of 6mdA in combination with 19 F NMR analysis and Chan–Lam coupling reaction.