Abstract Introduction Lymphocyte apoptosis and monocyte dysfunction play a pivotal role in sepsis-induced immunosuppression. Programmed death-1 (PD1) its ligand programmed death ligand-1 (PD-L1) exert inhibitory function by regulating the balance among T cell activation, tolerance, immunopathology. PD-1 deficiency or blockade has been shown to improve survival murine sepsis. However, PD-L1 differ their expression patterns of immunosuppression is still unknown. Methods Sepsis was induced...

Studies on the role of programmed death-1(PD-1) and its main ligand (PD-L1) during experimental models sepsis have shown that PD-1/PD-L1 pathway plays a pathologic in altering microbial clearance, innate inflammatory response accelerated apoptosis sepsis. However, expression PD-1 PD-L1 their development immune suppression septic patients not been elucidated. The present study was designed to determine whether is upregulated shock explore this sepsis-induced immunosuppression.Nineteen 22...

Abstract Background Ischemic stroke is the second leading cause of death globally. The narrow time window for administering effective thrombolytic therapy motivates search alternative prevention strategies. Microglia and astrocyte activation-mediated inflammation play a pivotal role in ischemic injury. Cottonseed oil (CSO) has been shown to exert anti-inflammatory effects against peripheral tissue injury, although CSO mostly used as solvent lipid-soluble drugs. However, neuroprotection not...

Background An imbalance between overwhelming inflammation and lymphocyte apoptosis is the main cause of high mortality in patients with sepsis. Baicalin, active ingredient Scutellaria root, exerts anti-inflammatory, anti-apoptotic, even antibacterial properties inflammatory infectious diseases. However, therapeutic effect baicalin on polymicrobial sepsis remains unknown. Methodology/Principal Findings Polymicrobial was induced by cecal ligation puncture (CLP) C57BL/6 mice. Mice were infused...

Sepsis-associated encephalopathy (SAE) is a poorly understood condition that leads to long-term cognitive impairment and increased mortality in survivors. Recent research revealed IL-17A/IL-17R might serve as checkpoint microglia-mediated neuroinflammation. The present study was designed determine the specific role of IL-17A-mediated microglia activation development SAE. A mouse model SAE induced by cecal ligation puncture (CLP), behavior performance evaluated inhibitory avoidance test open...

The objective of this study was to identify and characterize the most highly cited clinical research articles published on sepsis.A comprehensive list citation classics in sepsis generated by searching database Web Science-Expanded (1970 present) using keywords 'sepsis' or 'septic shock'. top 50 papers were retrieved reading abstract full text if needed. Each eligible article reviewed for basic information, including country origin, type, journals, authors, funding sources.A total 2,151 more...

Little evidence on the association between geriatric nutritional risk index (GNRI) with prognosis and postoperative complications was observed. This study examined potential prognostic value of GNRI in elderly patients undergoing non-cardiac surgery. retrospective analysis data retried from Chinese patients' perioperative database (CEPPD), a multicenter registry, June 1st, 2012 to August 15th, 2019. Patients were categorized into at-risk group (GNRI ≤ 98) no-risk > 98). Kaplan–Meier...

Objective: To identify the association between preoperative inflammatory state and myocardial injury after noncardiac surgery (MINS) in older patients using systemic inflammation indicators neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte (PLR), immune-inflammation index (SII) to compare their clinical predictive values. Methods: This study included aged ≥ 65 years who underwent January 2017 August 2019. The relationship MINS was investigated univariate multivariate logistic...

Integrating multiple pro-osteogenic factors into bone graft substitutes is a practical and effective approach to improve repair efficacy.

ABSTRACT Background Patients with diabetes are at a high risk for perioperative ischemic stroke (PIS). The use of biomarkers to identify high‐risk patients and predict PIS may provide considerable reference value in clinical decision‐making. aspartate transaminase/alanine transaminase ratio (De Ritis ratio) has been proven be associated specific diabetic complications. However, the association between De not evaluated this population. This retrospective cohort study aimed evaluate...

Abdominal sepsis refers to a severe and potentially life-threatening condition characterized by the presence of infection, inflammation, tissue damage within abdominal cavity. Glucocorticoids (GCs) play an important role in regulation host immune inflammation responses involved surgery. This study aimed investigate potential impact intraoperative GCs administration on clinical outcome surgical patients with sepsis. retrospective cohort included 1:1 propensity score-matched afflicted at two...

<sec> <title>BACKGROUND</title> Postoperative delirium (POD) is commonly encountered among older surgical patients and associated with increased healthcare costs. Comprehensive studies focusing on the economic burden of POD in China are lacking, despite rapid aging population. </sec> <title>OBJECTIVE</title> In this study, we assess changes costs Chinese who developed identify specific cost-driving factors. <title>METHODS</title> This retrospective cohort study analyzed perioperative data...

Purpose The current study aimed to elucidate the role of peritoneal fluid IL-17A in septic mice, and effects intraperitoneal or intravenous blockade pathway by anti-IL17A antibody on survival, plasma, cavity cytokine profile a murine caecal ligation puncture (CLP) sepsis model. main source mice was identified. Methods Male C57BL/6 that underwent severe CLP sham surgery were intraperitoneally intravenously administered antibodies isotype antibodies. survival rates observed. IL-17A, TNF-α,...

To determine the association between intraoperative renal tissue desaturation as measured using near-infrared spectroscopy and increased likelihood of developing postoperative acute kidney injury (AKI) in older patients undergoing hepatectomy. A multicenter prospective cohort study. The study was conducted at two tertiary hospitals China from September 2020 to October 2021. 157 (≥ 60 years) open hepatectomy surgery. Renal oxygen saturation continuously monitored during operation...

Sepsis is a systemic syndrome involving physiological, pathological, and biochemical abnormalities precipitated by infection major global public health problem. Endothelial cells (ECs) dysfunction contributor to sepsis-induced multiple organ failure. This bibliometric analysis aimed identify characterize the status, evolution of field, new research trends ECs sepsis over past 20 years. For this analysis, Web Science Core Collection database was searched relevant publications on in published...

Postoperative delirium is a common complication in older patients, with poor long-term outcomes. This study aimed to investigate risk factors and develop predictive model for postoperative patients after major abdominal surgery. retrospectively recruited 7577 aged ≥ 65 years who underwent surgery between January 2014 December 2018 single hospital Beijing, China. Patients were divided into training cohort (n = 5303) validation 2224) univariate multivariate logistic regression analyses build...

Abstract Background Myocardial injury after non-cardiac surgery (MINS) is a common and insidious postoperative complication. This study aimed to evaluate the relationship between triglyceride-glucose index (TyG) MINS in advanced-age patients. Methods We performed single-center retrospective including patients ≥ 65 years of age who underwent surgery. The TyG was investigated using univariate multivariate logistic regression analyses. Multivariate analysis involved three models: Model I...

Propofol postconditioning (P‑PostC) offers cardioprotection in mice, and the upregulation of autophagy protects cardiac cells against ischemia/reperfusion injury. The present study aimed to examine effects P‑PostC on induction its potential roles hypoxia/reoxygenation (H/R) Rat heart‑derived H9c2 were exposed H/R, comprising 6 h hypoxia followed by 4 reoxygenation, as well with various concentrations propofol at onset reperfusion. Lactate dehydrogenase (LDH) activity rate cell apoptosis...

Lymphocyte activation gene 3 (LAG-3) is one of the immune checkpoint molecules, negatively regulating T-cell reactions. The present study investigated role LAG-3 in sepsis-induced T-lymphocyte disability.Mice sepsis was induced by cecal ligation and puncture (CLP). expression on some cells were detected 24 hours after CLP. knockout anti-LAG-3 antibody applied to investigate effects survival, bacterial clearance. Cytokine levels, counts, presence apoptosis (in blood, spleen, thymus) also...

The settings of mechanical ventilation, like tidal volume (VT), occasionally need to be adjusted in the process anesthesia for some special reasons. aim this study was therefore assess relationship between pulse pressure variations (PPVs) different VT anesthetized healthy patients under ventilation. Sixty nine ASA I-II scheduled gastrointestinal surgery general were included prospective study. All ventilated at a 6, 8 or 10 ml/kg (predicted body weight) with no positive end expiratory (PEEP)...

Background Midazolam is a short-acting benzodiazepine frequently used in the perioperative setting. This study aimed to investigate potential impact of intraoperative midazolam on postoperative delirium (POD) older patients undergoing non-cardiac surgery. Methods included aged ≥ 65 years who received general anaesthesia between April 2020 and 2022 multiple hospitals across China. POD occurring within 7 days was assessed using 3-minute Diagnostic Interview for Confusion Assessment Method...