A5101911277- Cytokine Signaling Pathways and Interactions
- Autophagy in Disease and Therapy
- interferon and immune responses
- Cancer Mechanisms and Therapy
- PI3K/AKT/mTOR signaling in cancer
- Medicinal Plant Pharmacodynamics Research
- Immune cells in cancer
- Protein Tyrosine Phosphatases
- Mycobacterium research and diagnosis
- Retinal Imaging and Analysis
- Genomics, phytochemicals, and oxidative stress
- Endoplasmic Reticulum Stress and Disease
- Estrogen and related hormone effects
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Radical Photochemical Reactions
- Galectins and Cancer Biology
- NF-κB Signaling Pathways
- Magnesium Alloys: Properties and Applications
- Bone Metabolism and Diseases
- Catalytic C–H Functionalization Methods
- Metal and Thin Film Mechanics
- Boron and Carbon Nanomaterials Research
- Sulfur-Based Synthesis Techniques
- Retinal Diseases and Treatments
Ocean University of China
2020-2022
Qingdao National Laboratory for Marine Science and Technology
2020-2022
Lanzhou University
1997-2020
Cleveland Clinic
2007-2014
Cleveland Clinic Lerner College of Medicine
2013-2014
gp130-linked cytokines such as interleukin-6 (IL-6) stimulate the formation of tyrosine-phosphorylated signal transducer and activator transcription 3 (P-STAT3), which activates many genes, including STAT3 gene itself. The resulting increase in concentration unphosphorylated (U-STAT3) drives a second wave expression genes RANTES , IL6 IL8 MET MRAS that do not respond directly to P-STAT3. Thus, U-STAT3 sustains cytokine-dependent signaling at late times through mechanism completely distinct...
Signal abnormalities in human cells usually cause unexpected consequences for individual health. We focus on these kinds of events involved JAK-STAT signal pathways, especially the ones triggered by aberrant activated STAT3, an oncoprotein which participates essential processes cell survival, growth and proliferation many types tumors, as well immune diseases. By establishing a STAT3 based high-throughput drug screening system lung cancer A549 cells, we have screened library from natural...
Radical-mediated 1,2-difunctionalization of olefins is a well-established synthetic technique widely used in the rapid construction structurally diverse molecular entities. However, radical-mediated 1,3-difunctionalization reactions are rare, and substrates generally limited to strained skeletons. Here, we report practical approach for available β,γ-unsaturated ketones via radical cascade process including visible light-irradiated addition, thermodynamic stability-driven 1,2-carbonyl...
Tamoxifen, a widely used modulator of the estrogen receptor (ER), targets ER-positive breast cancer preferentially. We powerful validation-based insertion mutagenesis method to find that expression dominant-negative, truncated form histone deacetylase ZIP led resistance tamoxifen. Consistently, increased full-length gives opposite phenotype, inhibiting genes whose products mediate resistance. An important example is JAK2 . By binding two specific sequences in promoter, suppresses expression....
Abstract Dynamic remodelling of the extracellular matrix (ECM) is a key feature cancer progression. Enzymes that modify ECM, such as metalloproteinases (MMPs), have long been recognised important targets anticancer therapy. Inflammatory cytokines are known to play role in regulating protease expression cancer. Here we describe identification gamma-activated site (GAS)-like, signal transducer and activator transcription (STAT) binding elements (SBEs) within proximal promoters MMP-1 MMP-3...
Janus kinase (JAK) 2 plays a pivotal role in the tumorigenesis of signal transducers and activators transcription (STAT) 3 constitutively activated solid tumors. JAK2 mutations are involved pathogenesis various types hematopoietic disorders, such as myeloproliferative polycythemia vera, essential thrombocythemia, primary myelofibrosis. Thus, small-molecular inhibitors targeting potent for therapy these diseases. In this study, we screened 1,062,608 drug-like molecules from ZINC database 2080...
Diabetic retinopathy (DR) is a common complication and the leading cause of blindness in patients with type 2 diabetes. DR has been shown to be closely correlated blood glucose levels duration However, onset progression also display clinical heterogeneity. We applied whole-exome sequencing RNA-seq approaches study gene mutation transcription profiles three groups diabetic extreme phenotypes onset, timing, disease progression, aiming identify genetic variants that may play roles pathogenesis...
Background: Cancer poses a serious threat to human health and survival, studies had been reported that imidazole or pyridine analogs play as an anti-cancer agent in cancer treatment. Meanwhile, Autophagy plays dual substantial role maintaining cellular homeostasis cancers, for it is either initiated rescue cells under stress executed promote autophagy cell death certain circumstances. Objective: TIP-6 was designed synthesized (7-(4-methoxyphenyl)-5,8α-diphenyl-1,2,3,7,8,...