A5100694859- Nanoplatforms for cancer theranostics
- Gas Sensing Nanomaterials and Sensors
- Advanced Chemical Sensor Technologies
- Analytical Chemistry and Sensors
- Nanoparticle-Based Drug Delivery
- Advanced Nanomaterials in Catalysis
- Plasmonic and Surface Plasmon Research
- Advanced biosensing and bioanalysis techniques
- Metal-Organic Frameworks: Synthesis and Applications
- Photodynamic Therapy Research Studies
- Semiconductor Quantum Structures and Devices
- Immunotherapy and Immune Responses
- Cancer, Hypoxia, and Metabolism
- Gold and Silver Nanoparticles Synthesis and Applications
- Advanced Optical Sensing Technologies
- Nanowire Synthesis and Applications
- Quantum Dots Synthesis And Properties
- Photonic and Optical Devices
- Metal and Thin Film Mechanics
- Silicon and Solar Cell Technologies
- Optical Network Technologies
- Perovskite Materials and Applications
- Advanced Photocatalysis Techniques
- Advanced Semiconductor Detectors and Materials
- Welding Techniques and Residual Stresses
Chongqing Vocational and Technical University of Mechatronics
2023-2025
Criminal Investigation Police University of China
2021-2024
Tsinghua University
2023-2024
Jilin University
2022-2024
Suzhou Research Institute
2024
Energy Research Institute
2024
Sichuan University
2022-2023
Zhejiang University of Technology
2023
Material Measurement Laboratory
2019-2022
First Affiliated Hospital of Gannan Medical University
2022
The deep and inner beds of solid tumors lack lymphocytic infiltration are subjected to various immune escape mechanisms. Reversing immunosuppression within the tumor is vital in clinical cancer therapy, however it remains a huge challenge. In this work, we have demonstrated use second window near-infrared (NIR(II)) photothermal treatment trigger more homogeneous deeper immunogenic cell death tumors, thereby eliciting both innate adaptive responses for control metastasis prevention....
While tumor-infiltrating cytotoxic T lymphocytes play a critical role in controlling tumor development, they are generally impotent an acidic microenvironment. Systemic treatment to neutralize acidity thus holds promise for the reversal of anergic state cells and improvement cell-associated immunotherapy. Herein, we report proof-of-concept RNAi nanoparticle-mediated therapeutic reversion restore antitumor functions potentiate checkpoint blockade therapy. Our strategy utilized vivo optimized...
Photodynamic therapy (PDT) still faces great challenges with suitable photosensitizers, oxygen supply, and reactive species (ROS) accumulation, especially in the tumor microenvironment, feathering hypoxia, high glucose metabolism. Herein, a carbon dots (CDs)-based bifunctional nanosystem (MnZ@Au), acting as photosensitizer nanozyme cascading oxidase (GOx)- catalase (CAT)-like reactivity, was developed for improving hypoxia regulating metabolism to enhance PDT. The MnZ@Au constructed using...
Intratumoral glucose depletion-induced cancer starvation represents an important strategy for anticancer therapy, but it is often limited by systemic toxicity, nonspecificity, and adaptive development of parallel energy supplies. Herein, we introduce a concept cascaded catalytic nanomedicine combining targeted tumor deoxygenation-activated chemotherapy efficient treatment with reduced toxicity. Briefly, nanoclustered enzymes were synthesized covalently cross-linking oxidase (GOx) catalase...
Both diffusion-limited and perfusion-limited hypoxia are associated with tumor progression, metastasis, the resistance to therapeutic modalities. A strategy that can efficiently overcome both types of enhance efficacy cancer treatment has not been reported yet. Here, it is shown by using biomimetic ultrathin graphdiyne oxide (GDYO) nanosheets, be simultaneously addressed toward an ideal photodynamic therapy (PDT). The GDYO which oxidized exfoliated from (GDY), able catalyze water oxidation...
Abstract Liver fibrosis is the leading risk factor for hepatocellular carcinoma. Both oxidative stress and inflammation promote progression of liver fibrosis, but existing therapeutic strategies tend to focus solely on one issue. Additionally, targeting pathological microstructures often neglected. Herein, an esterase‐responsive carbon quantum dot‐dexamethasone (CD‐Dex) developed therapy simultaneously target microstructures, scavenge reactive oxygen species (ROS), suppress inflammation....
<bold>PEG-BDP</bold> macro-photosensitizer was synthesized which showed imaging-guided photodynamic therapy.
Metal-organic framework (MOF)-based sensors, which have garnered considerable focus for their potential to enhance environmental monitoring and improve water quality by accurately consistently identifying antibiotic compounds in water, gained interest. With the help of pH value, an unusual instance single-crystal-to-single-crystal (SCSC) transition from three-dimensional (3D) Zn-framework {[Zn2(mbix)2(2,5-bda)2]·H2O} n (1) 3D 2-fold {[Zn4(mbix)4(2,5-bda)4]·H2O} (2) has been observed under...
Multidrug resistance (MDR) is the major cause for chemotherapy failure, which constitutes a formidable challenge in field of cancer therapy. The synergistic chemo-photothermal treatment has been reported to be potential strategy overcome MDR. In this work, rationally designed enzyme-degradable, hyperbranched polyphosphoester nanomedicines were developed reversing MDR via codelivery doxorubicin and IR-780 (hPPEDOX&IR) as combined amphiphilic polyphosphoesters with phosphate bond branching...
The alkaline hydrogen evolution reaction (HER) of MoS2 is hampered by its sluggish water dissociation kinetics as well limited edge sites. Herein, Ni3S2/MoS2 fabricated a model catalyst to highlight interfacial structural and electronic modulations for realizing high performance in the HER. Experiments density functional theory results demonstrate that coupled Ni3S2 species can not only promote adsorption H2O boost HER but also tailor inert plane create abundant unsaturated edge-like active...
Cancer stem cells and bulk cancer can be simultaneously targeted when using nanomedicine.
Sensing biomarkers in exhaled breath offers a potentially portable, cost-effective, and noninvasive strategy for disease diagnosis screening monitoring, while high sensitivity, wide sensing range, target specificity are critical challenges. We demonstrate deep learning-assisted plasmonic platform that can detect quantify gas-phase breath-related backgrounds of varying complexity. The interface consisted Au/SiO2 nanopillars covered with 15 nm metal-organic framework. A small camera was...
Sorafenib is a kinase inhibitor approved for the treatment of primary kidney cancer, advanced liver and radioactive iodine resistant thyroid carcinoma.
InGaAs/graphene Schottky photodiode has a low barrier height (SBH) which induces high dark current density. In this paper, an Al2O3thin film is inserted between the layer of InGaAs and graphene to suppress density for nearly two orders magnitude. As result, it distinct enhancement on performance that graphene/Al2O3/InGaAs near-infrared photodetector (NIR PD) under -0.4 V better responsivity 523.77 mA W-1and detectivity 4.42 × 1010cm Hz1/2/W 1064 nm incident light than graphene/InGaAs NIR PD....
Establishment of vaginal immune defenses at the mucosal interface layer through gene vaccines promise to prevent infectious diseases among females. Mucosal barriers composed a flowing mucus hydrogel and tightly conjugated epithelial cells (ECs), which represent main technical difficulties for vaccine development, reside in harsh, acidic human environment. Different from frequently employed viral vectors, two types nonviral nanocarriers were designed concurrently overcome induce responses....
MOF-coated NHA plasmonic gas sensor with high sensitivity and temperature-induced analyte discrimination.