A5002722901- Quantum Information and Cryptography
- Cancer-related molecular mechanisms research
- Hepatocellular Carcinoma Treatment and Prognosis
- Quantum Computing Algorithms and Architecture
- Immune Cell Function and Interaction
- HER2/EGFR in Cancer Research
- Immune cells in cancer
- Breast Cancer Treatment Studies
- Cancer Immunotherapy and Biomarkers
- Cancer Genomics and Diagnostics
- RNA regulation and disease
- Ferroptosis and cancer prognosis
- Advanced Thermodynamics and Statistical Mechanics
- Quantum and electron transport phenomena
- interferon and immune responses
- Quantum Mechanics and Applications
- Iron Metabolism and Disorders
- Hepatitis B Virus Studies
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Spectroscopy and Quantum Chemical Studies
- Immunotherapy and Immune Responses
- Cancer, Hypoxia, and Metabolism
- Protease and Inhibitor Mechanisms
- Monoclonal and Polyclonal Antibodies Research
Guangdong Academy of Medical Sciences
2022-2025
Guangdong Provincial People's Hospital
2022-2025
Southern Medical University
2025
Yangzhou University
2025
Guangdong Pharmaceutical University
2024
Shanxi Medical University
2024
Fu Wai Hospital
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
State Key Laboratory of Cardiovascular Disease
2024
Beijing Biocytogen (China)
2021-2023
Scaling up to a large number of qubits with high-precision control is essential in the demonstrations quantum computational advantage exponentially outpace classical hardware and algorithmic improvements. Here, we develop two-dimensional programmable superconducting processor, Zuchongzhi, which composed 66 functional tunable coupling architecture. To characterize performance whole system, perform random circuits sampling for benchmarking, system size 56 20 cycles. The cost simulation this...
Abstract Purpose: We used high-resolution oligonucleotide comparative genomic hybridization (CGH) arrays and matching gene expression array data to identify dysregulated genes classify breast cancers according copy number anomalies. Experimental Design: DNA was extracted from 106 pretreatment fine needle aspirations of stage II-III that received preoperative chemotherapy. CGH done using Agilent Human 4 × 44K arrays. Gene generated with Affymetrix U133A chips also available on 103 patients....
Background/Amis: Long non-coding RNAs (lncRNAs), a novel class of transcripts, have been shown to play critical roles in diverse cellular biological processes, including tumorigenesis. Small nucleolar RNA host gene 6 (SNHG6) regulates various processes cancer cells. However, the role SNHG6 gastric still remains be explored. The aim this study is investigate characteristic cancer.Quantitative real-time polymerase chain reaction (qRT-PCR) was used measure expression tissues and cell lines. MTT...
Itaconate is a well-known immunomodulatory metabolite; however, its role in hepatocellular carcinoma (HCC) remains unclear. Here, we find that macrophage-derived itaconate promotes HCC by epigenetic induction of Eomesodermin (EOMES)-mediated CD8+ T-cell exhaustion. Our results show the knockout immune-responsive gene 1 (IRG1), responsible for production, suppresses progression. Irg1 leads to decreased proportion PD-1+ and TIM-3+ T cells. Deletion or adoptive transfer cells shows...
Abstract BACKGROUND: The combination of increased parity and shorter breastfeeding duration might increase the odds least differentiated triple‐negative breast cancer (BC) phenotype, theoretically because an expanded progenitor cell population from each pregnancy would incompletely differentiate postpartum. METHODS: Subjects consisted a consecutive case series 2473 women treated for invasive between 2001 2006. Breast phenotype (triple‐negative BC, vs non–triple‐negative BC) was compared with...
An increased incidence of venous thromboembolism (VTE) is associated with anti-vascular endothelial growth factor (VEGF) treatment in cancer. However, the mechanism underlying this effect remains elusive. In study, we examined bevacizumab, a humanized monoclonal antibody against VEGF-A, on VTE murine xenograft A549 cell tumor model.Inferior vena cava stenosis model and FeCl3-induced saphenous vein thrombosis were performed mouse models human lung adenocarcinoma.We found that bevacizumab...
Background: Hepatocellular carcinoma (HCC) is one of the most leading causes cancer-related mortality worldwide.Immune checkpoint inhibitors (ICIs) have been proved to be beneficial for advanced HCC.Tumor mutational burden (TMB) an important predictor efficacy ICIs.However, genetic landscape Chinese HCC patients and association between TMB frequently mutated genes remain unclear.Methods: Whole-exome sequencing data 369 liver tumors from Cancer Genome Altas (TCGA) next generation (NGS) 657...
ABSTRACT Background Advances in imaging technology have enhanced the detection of pulmonary nodules. However, determining malignancy often requires invasive procedures or repeated radiation exposure, underscoring need for safer, noninvasive diagnostic alternatives. Analyzing exhaled volatile organic compounds (VOCs) shows promise, yet its effectiveness assessing nodules remains underexplored. Methods Employing a prospective study design from June 2023 to January 2024 at Affiliated Hospital...
Abstract The Leishmania homolog of receptors for activated C kinase (LACK) protein is derived from parasites L. major . polypeptide LACK 156–173 has been shown to confer protection against murine autoimmune arthritis. Fibroblast‐like synoviocytes (FLSs) play a pivotal role in the synovial invasion and joint destruction observed rheumatoid arthritis (RA). study reveals that 156‐173 can inhibit aggressive phenotype RA‐FLSs by restoring dysregulated fatty acid synthesis metabolism. In RA‐FLSs,...
Our goal was to examine the association between biological pathways and response chemotherapy in estrogen receptor (ER)-positive ER-negative breast cancers separately. Gene set enrichment analysis including 852 predefined gene sets, applied expression data from 51 82 ER-positive that were all treated with a preoperative paclitaxel, 5-fluoruracil, doxorubicin cyclophosphamide chemotherapy. Twenty-seven (53%) 7 (9%) patients had pathologic complete (pCR) therapy. Among cancers, proliferation...
The authors previously considered a method of solving optimization problems by using system interconnected network two component Bose-Einstein condensates (Byrnes, Yan, Yamamoto New J. Phys. 13, 113025 (2011)). use bosonic particles gives reduced time proportional to the number bosons N for Ising model Hamiltonians taking advantage enhanced cooling rates. Here we consider same in terms neural networks. We find that up accelerated proposed is equivalent stochastic continuous Hopfield network....
Abstract Macrophages are plastic cells that can switch among different states according to bioenergetic or biosynthetic requirements. Our previous work demonstrated the transcription factor Forkhead Box Protein 1 ( FoxO1 ) plays a pivotal role in regulating function of macrophages, but underlying mechanisms still unclear. Here we identify as regulator macrophage through metabolic reprogramming. Transcriptomic and proteomic analyses showed deficiency results an alternatively activated (M2)...
Long non-coding RNA (lncRNA) XIST has been implicated in the progression of a variety tumor diseases. The purpose this study was to explore molecular role lncRNA human hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC).
It is known that Toll-like receptor (TLR)-4 plays an important role in myocardial infarction and atherothrombosis. The of TLR-4 arterial thrombosis undefined. Both TLR-4-deficient (TLR-4(-/-)) wild-type (WT) mice were subjected to FeCl3 carotid artery injury, the time required form occlusive thrombus was measured. mean occlusion TLR-4(-/-) significantly greater than WT after injury (303 ± 32 vs. 165 34 s, P < 0.05). Furthermore, when we used a or TLR-4(-/-)-derived platelet reinfusion...
We performed gene expression analysis to identify molecular predictors of resistance preoperative concomitant trastuzumab and paclitaxel followed by 5-fluorouracil, epirubicin, cyclophosphamide (T/FEC).
Abstract Patient selection is important for targeted therapies, yet phase I/II trials are often underpowered developing predictors of drug response. The goal this research was to define genomic dasatinib that could be prospectively tested in early-phase clinical trials. Gene expression profiles dasatinib-sensitive and dasatinib-resistant cell lines (n = 23) were compared develop a dasatinib-sensitivity index (modified DS index). A Src pathway activity (revised index) defined using genes...
Severe aplastic anemia (SAA) is an autoimmune disease characterized by immune-mediated destruction of hematopoietic stem and progenitor cells. Autoreactive CD8+ T cells have been reported as the effector cells; however, mechanisms regulating their cell activation in SAA remain largely unknown. Here, we performed proteomics metabolomics analyses plasma bone marrow supernatant, together with transcriptional analysis from patients healthy donors, to find key pathways that are involved...
Background Thyroid tissue has a special immune microenvironment that is not well characterized. Whether cells have prognostic value in the recurrence of papillary thyroid cancer (PTC) needs further investigation. Methods Multinodular non-toxic goiter (MNG) was taken as normal for difficulty obtaining completely (normal function, no thyroiditis, and nodules). We compared composition mononuclear (MNCs) peripheral blood tissues from MNG PTC patients by high-dimensional flow cytometry profiling...
Clara cells are non-ciliated, secretory bronchiolar epithelial that serve to detoxify harmful inhaled substances. also function as stem/progenitor for repair in the bronchioles. cell protein (CCSP) is specifically expressed pulmonary and widely used a marker. In addition CCSP promoter commonly direct gene expression into lung transgenic models. The discovery of immunoreactivity plasma membranes airway lining prompted us explore possibility enriching by flow cytometry. We established novel...